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Novel prognostic molecular markers in lung cancer (Review)

  • Authors:
    • Michał Puderecki
    • Justyna Szumiło
    • Barbara Marzec‑Kotarska
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pathomorphology, The Medical University of Lublin, 20‑090 Lublin, Poland
  • Pages: 9-18
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    Published online on: April 15, 2020
       https://doi.org/10.3892/ol.2020.11541
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Abstract

Lung carcinoma, especially in its most commonly diagnosed non‑small cell histological form, is a challenge to diagnose and treat worldwide, due to the prognosis in patients with this type of cancer being poor and mortality rates being high. However, a number of patients with this type of lung carcinoma exhibit a longer than average overall survival. The specific molecular background of non‑small‑cell lung cancer that favors longer survival has not yet been determined. The aim of the current study was to review articles published in the years 2017‑2018 and create a list of the most important and strongest non‑conventional factors that could be used in the future assessment of the prognosis of patients with adenocarcinoma and squamous cell carcinoma of the lung who cannot undergo current targeted therapy. Analysis identified multiple prognostic factors in non‑small cell lung carcinoma, including tumor mutational burden, which was revealed to be independent of the tumor stage or grade as well as other factors, including age, sex or targeted therapy effects. The selected molecular factors exhibit the potential to be used in the treatment of patients with specific problematic lung cancer, and may contribute to setting recommendations for the diagnosis, prognosis and treatment of individual patients with lung cancer.
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1 

Torre LA, Siegel RL and Jemal A: Lung cancer statistics. Adv Exp Med Biol. 893:1–19. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Pardo J, Martinez-Peñuela AM, Sola JJ, Panizo A, Gúrpide A, Martinez-Peñuela JM and Lozano MD: Large cell carcinoma of the lung: An endangered species? Appl Immunohistochem Mol Morphol. 17:383–392. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Tomasetti C, Marchionni L, Nowak MA, Parmigiani G and Vogelstein B: Only three driver gene mutations are required for the development of lung and colorectal cancers. Proc Natl Acad Sci USA. 112:118–123. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Taylor CR, Shi SR, Barr NJ and Wu N: Techniques of immunohistochemistry: Principles, pitfalls and standardization. Diagnostic Immunohistochemistry (Second). 1–42. 2006. View Article : Google Scholar

5 

Jin BF, Yang F, Ying XM, Gong L, Hu SF, Zhao Q, Liao YD, Chen KZ, Li T, Tai YH, et al: Signaling protein signature predicts clinical outcome of non-small-cell lung cancer. BMC Cancer. 18:2592018. View Article : Google Scholar : PubMed/NCBI

6 

Gu Z, Fang X, Li C, Chen C, Liang G, Zheng X and Fan Q: Increased PTPRA expression leads to poor prognosis through c-Src activation and G1 phase progression in squamous cell lung cancer. Int J Oncol. 51:489–497. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Phelps CA, Lai SC and Mu D: Roles of thyroid transcription factor 1 in lung cancer biology. Vitam Horm. 106:517–544. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Takahashi H, Ogata H, Nishigaki R, Broide DH and Karin M: Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. Cancer Cell. 17:89–97. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Zhao C, Li X, Su C, Li J, Cheng N, Ren S, Chen X and Zhou C: High expression of E-cadherin in pleural effusion cells predicts better prognosis in lung adenocarcinoma patients. Int J Clin Exp Pathol. 8:3104–3109. 2015.PubMed/NCBI

10 

Min J, Huang K, Tang H, Ding X, Qi C, Qin X and Xu Z: Phloretin induces apoptosis of non-small cell lung carcinoma A549 cells via JNK1/2 and p38 MAPK pathways. Oncol Rep. 34:2871–2879. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Huang LN, Wang DS, Chen YQ, Li W, Hu FD, Gong BL, Zhao CL and Jia W: Meta-analysis for cyclin E in lung cancer survival. Clin Chim Acta. 413:663–668. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Rao G, Pierobon M, Kim IK, Hsu WH, Deng J, Moon YW, Petricoin EF, Zhang YW, Wang Y and Giaccone G: Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations. Sci Rep. 7:70662017. View Article : Google Scholar : PubMed/NCBI

13 

Correia LL, Johnson JA, McErlean P, Bauer J, Farah H, Rassl DM, Rintoul RC, Sethi T, Lavender P, Rawlins EL, et al: SOX2 drives bronchial dysplasia in a novel organotypic model of early human squamous lung cancer. Am J Respir Crit Care Med. 195:1494–1508. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Yang Z, Yang F, Zhang Y, Wang X, Shi J, Wei H, Sun F and Yu Y: Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer. Exp Ther Med. 15:2837–2843. 2018.PubMed/NCBI

15 

Wan T, Shao J, Hu B, Liu G, Luo P and Zhou Y: Prognostic role of HSF1 overexpression in solid tumors: A pooled analysis of 3,159 patients. Onco Targets Ther. 11:383–393. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Tsukao Y, Yamasaki M, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Miyata H, Nakajima K, Takiguchi S, Mimori K, et al: Overexpression of heat-shock factor 1 is associated with a poor prognosis in esophageal squamous cell carcinoma. Oncol Lett. 13:1819–1825. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Gökmen-Polar Y and Badve S: Upregulation of HSF1 in estrogen receptor positive breast cancer. Oncotarget. 7:84239–84245. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Chuma M, Sakamoto N, Nakai A, Hige S, Nakanishi M, Natsuizaka M, Suda G, Sho T, Hatanaka K, Matsuno Y, et al: Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor-κB/mitogen-activated protein kinase. Carcinogenesis. 35:272–281. 2014. View Article : Google Scholar : PubMed/NCBI

19 

White GE, Tan TC, John AE, Whatling C, McPheat WL and Greaves DR: Fractalkine has anti-apoptotic and proliferative effects on human vascular smooth muscle cells via epidermal growth factor receptor signalling. Cardiovasc Res. 85:825–835. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Ohta M, Tanaka F, Yamaguchi H, Sadanaga N, Inoue H and Mori M: The high expression of fractalkine results in a better prognosis for colorectal cancer patients. Int J Oncol. 26:41–47. 2005.PubMed/NCBI

21 

Hyakudomi M, Matsubara T, Hyakudomi R, Yamamoto T, Kinugasa S, Yamanoi A, Maruyama R and Tanaka T: Increased expression of fractalkine is correlated with a better prognosis and an increased number of both CD8+ T cells and natural killer cells in gastric adenocarcinoma. Ann Surg Oncol. 15:1775–1782. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Park MH, Lee JS and Yoon JH: High expression of CX3CL1 by tumor cells correlates with a good prognosis and increased tumor-infiltrating CD8+ T cells, natural killer cells, and dendritic cells in breast carcinoma. J Surg Oncol. 106:386–392. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Su YC, Chang H, Sun SJ, Liao CY, Wang LY, Ko JL and Chang JT: Differential impact of CX3CL1 on lung cancer prognosis in smokers and non-smokers. Mol Carcinog. 57:629–639. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Folescu R, Levai CM, Grigoraş ML, Arghirescu TS, Talpoş IC, Gîndac CM, Zamfir CL, Poroch V and Anghel MD: Expression and significance of Ki-67 in lung cancer. Rom J Morphol Embryol. 59:227–233. 2018.PubMed/NCBI

25 

Villa E, Proïcs E, Rubio-Patiño C, Obba S, Zunino B, Bossowski JP, Rozier RM, Chiche J, Mondragón L, Riley JS, et al: Parkin-independent mitophagy controls chemotherapeutic response in cancer cells. Cell Rep. 20:2846–2859. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Zhang R, Gu J, Chen J, Ni J, Hung J, Wang Z, Zhang X, Feng J and Ji L: High expression of PINK1 promotes proliferation and chemoresistance of NSCLC. Oncol Rep. 37:2137–2146. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Chang G, Zhang W, Ma Y and Wen Q: PINK1 expression is associated with poor prognosis in lung adenocarcinoma. Tohoku J Exp Med. 245:115–121. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Chuang CY, Chen MK, Hsieh MJ, Yeh CM, Lin CW, Yang WE, Yang SF and Chou YE: High level of plasma EGFL6 is associated with clinicopathological characteristics in patients with oral squamous cell carcinoma. Int J Med Sci. 14:419–424. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Bai S, Ingram P, Chen YC, Deng N, Pearson A, Niknafs YS, O'Hayer P, Wang Y, Zhang ZY, Boscolo E, et al: EGFL6 regulates the asymmetric division, maintenance, and metastasis of ALDH+ ovarian cancer cells. Cancer Res. 76:6396–6409. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Chang CC, Sung WW, Hsu HT, Yeh CM, Lee CH, Chen YL, Liu TC and Yeh KT: Validation of EGFL6 expression as a prognostic marker in patients with lung adenocarcinoma in Taiwan: A retrospective study. BMJ Open. 8:e0213852018. View Article : Google Scholar : PubMed/NCBI

31 

Zhang Y, Qiao WB and Shan L: Expression and functional characterization of FOXM1 in non-small cell lung cancer. Onco Targets Ther. 11:3385–3393. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Sun Q, Dong M, Chen Y, Zhang J, Qiao J and Guo X: Prognostic significance of FoxM1 expression in non-small cell lung cancer. J Thorac Dis. 8:1269–1273. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Kim MS, Kim E, Heo JS, Bae DJ, Lee JU, Lee TH, Lee HJ, Chang HS, Park JS, Jang AS, et al: Circulating IL-33 level is associated with the progression of lung cancer. Lung Cancer. 90:346–351. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Yang M, Feng Y, Yue C, Xu B, Chen L, Jiang J, Lu B and Zhu Y: Lower expression level of IL-33 is associated with poor prognosis of pulmonary adenocarcinoma. PLoS One. 13:e01934282018. View Article : Google Scholar : PubMed/NCBI

35 

Deng Y, Ge P, Tian T, Dai C, Wang M, Lin S, Liu K, Zheng Y, Xu P, Zhou L, et al: Prognostic value of flotillins (flotillin-1 and flotillin-2) in human cancers: A meta-analysis. Clin Chim Acta. 481:90–98. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Wang YL, Yao WJ, Guo L, Xi HF, Li SY and Wang ZM: Expression of flotillin-2 in human non-small cell lung cancer and its correlation with tumor progression and patient survival. Int J Clin Exp Pathol. 8:601–607. 2015.PubMed/NCBI

37 

Wen Q, Wang W, Chu S, Luo J, Chen L, Xie G, Xu L, Li M and Fan S: Flot-2 expression correlates with EGFR levels and poor prognosis in surgically resected non-small cell lung cancer. PLoS One. 10:e01321902015. View Article : Google Scholar : PubMed/NCBI

38 

Feng C, Feng M, Gao Y, Zhao X, Peng C, Yang X and Zhang J: Clinicopathologic significance of intestinal-type molecules' expression and different EGFR gene status in pulmonary adenocarcinoma. Appl Immunohistochem Mol Morphol. Feb 27–2018.(Epub ahead of print). PubMed/NCBI

39 

Litan A and Langhans SA: Cancer as a channelopathy: Ion channels and pumps in tumor development and progression. Front Cell Neurosci. 9:862015. View Article : Google Scholar : PubMed/NCBI

40 

Prevarskaya N, Skryma R and Shuba Y: Ion channels and the hallmarks of cancer. Trends Mol Med. 16:107–121. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Suo A, Childers A, D'Silva A, Petersen LF, Otsuka S, Dean M, Li H, Enwere EK, Pohorelic B, Klimowicz A, et al: Cav3.1 overexpression is associated with negative characteristics and prognosis in non-small cell lung cancer. Oncotarget. 9:8573–8583. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Zhou H, Cai L, Zhang X, Li A, Miao Y, Li Q, Qiu X and Wang E: ARHGEF39 promotes tumor progression via activation of Rac1/P38 MAPK/ATF2 signaling and predicts poor prognosis in non-small cell lung cancer patients. Lab Invest. 98:670–681. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Wang Q, Chen Y, Feng H, Zhang B and Wang H: Prognostic and predictive value of HURP in non-small cell lung cancer. Oncol Rep. 39:1682–1692. 2018.PubMed/NCBI

44 

Hu G and Wang S: Prognostic role of tumor-infiltrating CD57-positive lymphocytes in solid tumors: A meta-analysis. Oncotarget. 9:8111–8119. 2017.PubMed/NCBI

45 

Nielsen CM, White MJ, Goodier MR and Riley EM: Functional significance of CD57 expression on human NK cells and relevance to disease. Front Immunol. 4:4222013. View Article : Google Scholar : PubMed/NCBI

46 

Badalamenti G, Fanale D, Incorvaia L, Barraco N, Listì A, Maragliano R, Vincenzi B, Calò V, Iovanna JL, Bazan V and Russo A: Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone? Cell Immunol. 343:1037532019. View Article : Google Scholar : PubMed/NCBI

47 

Peng Y and Croce CM: The role of MicroRNAs in human cancer. Signal Transduct Target Ther. 1:150042016. View Article : Google Scholar : PubMed/NCBI

48 

Dong Y and Qiu GB: Biological functions of miR-590 and its role in carcinogenesis. Front Lab Med. 1:173–176. 2017. View Article : Google Scholar

49 

Ma Z, Wang Y, He B, Cui J, Zhang C, Wang H, Feng W, Wang B, Wei D, Wu Y, et al: Expression of miR-590 in lung cancer and its correlation with prognosis. Oncol Lett. 15:1753–1757. 2018.PubMed/NCBI

50 

Testa U, Pelosi E, Castelli G and Labbaye C: miR-146 and miR-155: Two key modulators of immune response and tumor development. Noncoding RNA. 3(pii): E222017.PubMed/NCBI

51 

Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, et al: Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 9:189–198. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Li P, Sun Y and Liu Q: MicroRNA-340 induces apoptosis and inhibits metastasis of ovarian cancer cells by inactivation of NF-κB1. Cell Physiol Biochem. 38:1915–1927. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, et al: MicroRNA expression profiles classify human cancers. Nature. 435:834–838. 2005. View Article : Google Scholar : PubMed/NCBI

54 

Qin Y, Zhou X, Huang C, Li L, Liu H, Liang N, Chen Y, Ma D, Han Z, Xu X, et al: Lower miR-340 expression predicts poor prognosis of non-small cell lung cancer and promotes cell proliferation by targeting CDK4. Gene. 675:278–284. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Ghoshal-Gupta S, Kutiyanawalla A, Lee BR, Ojha J, Nurani A, Mondal AK, Kolhe R, Rojiani AM and Rojiani MV: TIMP-1 downregulation modulates miR-125a-5p expression and triggers the apoptotic pathway. Oncotarget. 9:8941–8956. 2018. View Article : Google Scholar : PubMed/NCBI

56 

Zhu WY, Luo B, An JY, He JY, Chen DD, Xu LY, Huang YY, Liu XG, Le HB and Zhang YK: Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer. Cancer Invest. 32:394–401. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Faversani A, Amatori S, Augello C, Colombo F, Porretti L, Fanelli M, Ferrero S, Palleschi A, Pelicci PG, Belloni E, et al: miR-494-3p is a novel tumor driver of lung carcinogenesis. Oncotarget. 8:7231–7247. 2017. View Article : Google Scholar : PubMed/NCBI

58 

Chen Y, Min L, Ren C, Xu X, Yang J, Sun X, Wang T, Wang F, Sun C and Zhang X: MiRNA-148a serves as a prognostic factor and suppresses migration and invasion through Wnt1 in non-small cell lung cancer. PLoS One. 12:e01717512017. View Article : Google Scholar : PubMed/NCBI

59 

Bach DH, Lee SK and Sood AK: Circular RNAs in cancer. Mol Ther Nucleic Acids. 16:118–129. 2019. View Article : Google Scholar : PubMed/NCBI

60 

Ding L, Yao W, Lu J, Gong J and Zhang X: Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non-small cell lung cancer by regulating the Wnt/β-catenin pathway. Oncol Lett. 16:453–458. 2018.PubMed/NCBI

61 

Xu S, Wan L, Yin H, Xu H, Zheng W, Shen M, Zhang Z and Pang D: Long noncoding RNA Linc00152 functions as a tumor propellant in pan-cancer. Cell Physiol Biochem. 44:2476–2490. 2017. View Article : Google Scholar : PubMed/NCBI

62 

Feng S, Zhang J, Su W, Bai S, Xiao L, Chen X, Lin J, Reddy RM, Chang AC, Beer DG and Chen G: Overexpression of LINC00152 correlates with poor patient survival and knockdown impairs cell proliferation in lung cancer. Sci Rep. 7:29822017. View Article : Google Scholar : PubMed/NCBI

63 

Chen M, Liu B, Xiao J, Yang Y and Zhang Y: A novel seven-long non-coding RNA signature predicts survival in early stage lung adenocarcinoma. Oncotarget. 8:14876–14886. 2017.PubMed/NCBI

64 

Zheng S, Zheng D, Dong C, Jiang J, Xie J, Sun Y and Chen H: Development of a novel prognostic signature of long non-coding RNAs in lung adenocarcinoma. J Cancer Res Clin Oncol. 143:1649–1657. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Liu B, Chen Y and Yang J: LncRNAs are altered in lung squamous cell carcinoma and lung adenocarcinoma. Oncotarget. 8:24275–24291. 2017.PubMed/NCBI

66 

Zhao K, Li Z and Tian H: Twenty-gene-based prognostic model predicts lung adenocarcinoma survival. Onco Targets Ther. 11:3415–3424. 2018. View Article : Google Scholar : PubMed/NCBI

67 

Shen S, Wei Y, Zhang R, Du M, Duan W, Yang S, Zhao Y, Christiani DC and Chen F: Mutant-allele fraction heterogeneity is associated with non-small cell lung cancer patient survival. Oncol Lett. 15:795–802. 2018.PubMed/NCBI

68 

Heeke S and Hofman P: Tumor mutational burden assessment as a predictive biomarker for immunotherapy in lung cancer patients: Getting ready for prime-time or not? Transl Lung Cancer Res. 7:631–638. 2018. View Article : Google Scholar : PubMed/NCBI

69 

Owada-Ozaki Y, Muto S, Takagi H, Inoue T, Watanabe Y, Fukuhara M, Yamaura T, Okabe N, Matsumura Y, Hasegawa T, et al: Prognostic impact of tumor mutation burden in patients with completely resected non-small cell lung cancer: Brief report. J Thorac Oncol. 13:1217–1221. 2018. View Article : Google Scholar : PubMed/NCBI

70 

Devarakonda S, Rotolo F, Tsao MS, Lanc I, Brambilla E, Masood A, Olaussen KA, Fulton R, Sakashita S, McLeer-Florin A, et al: Tumor mutation burden as a biomarker in resected non-small-cell lung cancer. J Clin Oncol. 36:2995–3006. 2018. View Article : Google Scholar : PubMed/NCBI

71 

Sethi G, Shanmugam MK, Arfuso F and Kumar AP: Role of RNF20 in cancer development and progression-a comprehensive review. Biosci Rep. 38(pii): BSR201712872018. View Article : Google Scholar : PubMed/NCBI

72 

Woodard GA, Jones KD and Jablons DM: Lung cancer staging and prognosis. Lung Cancer Ttreat Res. 170:47–75. 2016. View Article : Google Scholar

73 

Yang Y, Xie Y and Xian L: Breast cancer susceptibility gene 1 (BRCA1) predict clinical outcome in platinum- and toxal-based chemotherapy in non-small-cell lung cancer (NSCLC) patients: A system review and meta-analysis. J Exp Clin Cancer Res. 32:152013. View Article : Google Scholar : PubMed/NCBI

74 

Gong W, Zhang X, Wu J, Chen L, Li L, Sun J, Lv Y, Wei X, Du Y, Jin H and Dong J: RRM1 expression and clinical outcome of gemcitabine-containing chemotherapy for advanced non-small-cell lung cancer: A meta-analysis. Lung Cancer. 75:374–380. 2012. View Article : Google Scholar : PubMed/NCBI

75 

Deng B, Sun Z, Jason W and Yang P: Increased BCAR1 predicts poor outcomes of non-small cell lung cancer in multiple-center patients. Ann Surg Oncol. 20 (Suppl 3):S701–S708. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Puderecki M, Szumiło J and Marzec‑Kotarska B: Novel prognostic molecular markers in lung cancer (Review). Oncol Lett 20: 9-18, 2020.
APA
Puderecki, M., Szumiło, J., & Marzec‑Kotarska, B. (2020). Novel prognostic molecular markers in lung cancer (Review). Oncology Letters, 20, 9-18. https://doi.org/10.3892/ol.2020.11541
MLA
Puderecki, M., Szumiło, J., Marzec‑Kotarska, B."Novel prognostic molecular markers in lung cancer (Review)". Oncology Letters 20.1 (2020): 9-18.
Chicago
Puderecki, M., Szumiło, J., Marzec‑Kotarska, B."Novel prognostic molecular markers in lung cancer (Review)". Oncology Letters 20, no. 1 (2020): 9-18. https://doi.org/10.3892/ol.2020.11541
Copy and paste a formatted citation
x
Spandidos Publications style
Puderecki M, Szumiło J and Marzec‑Kotarska B: Novel prognostic molecular markers in lung cancer (Review). Oncol Lett 20: 9-18, 2020.
APA
Puderecki, M., Szumiło, J., & Marzec‑Kotarska, B. (2020). Novel prognostic molecular markers in lung cancer (Review). Oncology Letters, 20, 9-18. https://doi.org/10.3892/ol.2020.11541
MLA
Puderecki, M., Szumiło, J., Marzec‑Kotarska, B."Novel prognostic molecular markers in lung cancer (Review)". Oncology Letters 20.1 (2020): 9-18.
Chicago
Puderecki, M., Szumiło, J., Marzec‑Kotarska, B."Novel prognostic molecular markers in lung cancer (Review)". Oncology Letters 20, no. 1 (2020): 9-18. https://doi.org/10.3892/ol.2020.11541
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