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Selective inhibition of HDAC6 sensitizes cutaneous T‑cell lymphoma to PI3K inhibitors

  • Authors:
    • Malgorzata Bobrowicz
    • Aleksander Slusarczyk
    • Joanna Domagala
    • Michal Dwojak
    • Desislava Ignatova
    • Yun‑Tsan Chang
    • Christoph Iselin
    • Nina Miazek‑Zapala
    • Katsiaryna Marhelava
    • Emmanuella Guenova
    • Magdalena Winiarska
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Medical University of Warsaw, 02‑097 Warsaw, Poland, Department of Dermatology, University Hospital Zürich, University of Zurich, 8091 Zurich, Switzerland, Postgraduate School of Molecular Medicine, Medical University of Warsaw, 02‑097 Warsaw, Poland
    Copyright: © Bobrowicz et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 533-540
    |
    Published online on: May 6, 2020
       https://doi.org/10.3892/ol.2020.11587
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Abstract

Histone deacetylase (HDAC) inhibitors, approved for the treatment of cutaneous T-cell lymphoma (CTCL), are non‑selective agents associated with an unsatisfactory response and considerable side‑effects. Targeting single HDAC isoforms is considered to provide novel therapeutic options. HDAC6 is overexpressed in primary samples from patients with CTCL and preclinical studies using transgenic mice that spontaneously develop a CTCL‑like disease, have suggested that combinations including HDAC6 inhibitors may be successful in the treatment of CTCL. PI3K inhibition is currently being tested in clinical trials for CTCL with promising results. Since HDAC6 is known to diminish the activity of Akt via its deacetylation, the aim of the present study was to evaluate the therapeutic potential of selective HDAC6 inhibitors in combination with PI3K inhibitors in CTCL. Through the genetic and pharmacological inhibition of HDAC6, it was demonstrated that combining HDAC6 with PI3K inhibition may be an attractive therapeutic option for patients with CTCL.
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Copy and paste a formatted citation
Spandidos Publications style
Bobrowicz M, Slusarczyk A, Domagala J, Dwojak M, Ignatova D, Chang YT, Iselin C, Miazek‑Zapala N, Marhelava K, Guenova E, Guenova E, et al: Selective inhibition of HDAC6 sensitizes cutaneous T‑cell lymphoma to PI3K inhibitors. Oncol Lett 20: 533-540, 2020.
APA
Bobrowicz, M., Slusarczyk, A., Domagala, J., Dwojak, M., Ignatova, D., Chang, Y. ... Winiarska, M. (2020). Selective inhibition of HDAC6 sensitizes cutaneous T‑cell lymphoma to PI3K inhibitors. Oncology Letters, 20, 533-540. https://doi.org/10.3892/ol.2020.11587
MLA
Bobrowicz, M., Slusarczyk, A., Domagala, J., Dwojak, M., Ignatova, D., Chang, Y., Iselin, C., Miazek‑Zapala, N., Marhelava, K., Guenova, E., Winiarska, M."Selective inhibition of HDAC6 sensitizes cutaneous T‑cell lymphoma to PI3K inhibitors". Oncology Letters 20.1 (2020): 533-540.
Chicago
Bobrowicz, M., Slusarczyk, A., Domagala, J., Dwojak, M., Ignatova, D., Chang, Y., Iselin, C., Miazek‑Zapala, N., Marhelava, K., Guenova, E., Winiarska, M."Selective inhibition of HDAC6 sensitizes cutaneous T‑cell lymphoma to PI3K inhibitors". Oncology Letters 20, no. 1 (2020): 533-540. https://doi.org/10.3892/ol.2020.11587
Copy and paste a formatted citation
x
Spandidos Publications style
Bobrowicz M, Slusarczyk A, Domagala J, Dwojak M, Ignatova D, Chang YT, Iselin C, Miazek‑Zapala N, Marhelava K, Guenova E, Guenova E, et al: Selective inhibition of HDAC6 sensitizes cutaneous T‑cell lymphoma to PI3K inhibitors. Oncol Lett 20: 533-540, 2020.
APA
Bobrowicz, M., Slusarczyk, A., Domagala, J., Dwojak, M., Ignatova, D., Chang, Y. ... Winiarska, M. (2020). Selective inhibition of HDAC6 sensitizes cutaneous T‑cell lymphoma to PI3K inhibitors. Oncology Letters, 20, 533-540. https://doi.org/10.3892/ol.2020.11587
MLA
Bobrowicz, M., Slusarczyk, A., Domagala, J., Dwojak, M., Ignatova, D., Chang, Y., Iselin, C., Miazek‑Zapala, N., Marhelava, K., Guenova, E., Winiarska, M."Selective inhibition of HDAC6 sensitizes cutaneous T‑cell lymphoma to PI3K inhibitors". Oncology Letters 20.1 (2020): 533-540.
Chicago
Bobrowicz, M., Slusarczyk, A., Domagala, J., Dwojak, M., Ignatova, D., Chang, Y., Iselin, C., Miazek‑Zapala, N., Marhelava, K., Guenova, E., Winiarska, M."Selective inhibition of HDAC6 sensitizes cutaneous T‑cell lymphoma to PI3K inhibitors". Oncology Letters 20, no. 1 (2020): 533-540. https://doi.org/10.3892/ol.2020.11587
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