Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2020 Volume 20 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2020 Volume 20 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Long non‑coding RNA AC023794.4‑201 exerts a tumor‑suppressive function in laryngeal squamous cell cancer and may serve as a potential prognostic biomarker

  • Authors:
    • Zhisen Shen
    • Jie Yuan
    • Qiaoling Tong
    • Wenjuan Hao
    • Hongxia Deng
    • Qun Li
    • Chongchang Zhou
    • Yan Hu
    • Jie Xu
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology and Head and Neck Surgery, Li Huili Hospital Affiliated to Ningbo University, Ningbo, Zhejiang 315040, P.R. China, Department of Otorhinolaryngology and Head and Neck Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, P.R. China
    Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 774-784
    |
    Published online on: May 7, 2020
       https://doi.org/10.3892/ol.2020.11595
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

After the expression level of lncRNA AC023794.4‑201 was upregulated in 2 laryngeal squamous cell carcinoma (LSCC) cell lines (AMC‑HN‑8 and TU‑212) and LSCC xenografts, the biological function of lncRNA AC023794.4‑201 in LSCC was further investigated using in vitro and in vivo experiments, such as cell function experiments and nude mice transplantation. In our previous study, it was demonstrated that the expression level of the long non‑coding RNA (lncRNA) AC023794.4‑201 were decreased in laryngeal squamous cell carcinoma, particularly in cases of LSCC with lymphatic metastasis. Moreover, low expression levels of AC023794.4‑201 were revealed to be an adverse prognostic factor for patients with LSCC. In the present study, lentiviruses were used to overexpress AC023794.4‑201 before a series of cell function assays were performed and a xenograft nude mouse model was constructed, in order to further investigate the functions of AC023794.4‑201 in LSCC. AC023794.4‑201 inhibited the proliferation and the cloning capacity of LSCC cells compared with the negative control group as indicated by real‑time cell analysis and the plate colony formation assay. Flow cytometry and transwell migration assays demonstrated that AC023794.4‑201 inhibited the migration, induced cell cycle arrest and increased the apoptotic rate of LSCC cells. The results of the in vivo studies demonstrated that AC023794.4‑201 significantly inhibited the growth of LSCC xenografts, and promoted apoptosis. In conclusion, the findings of the present study suggested that AC023794.4‑201 may exert tumor‑suppressive functions in the progression of LSCC and may serve as a potential prognostic biomarker for LSCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Pantel M and Guntinas-Lichius O: Laryngeal carcinoma: Epidemiology, risk factors and survival. HNO. 60:32–40. 2012.(In German). View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Steuer CE, El-Deiry M, Parks JR, Higgins KA and Saba NF: An update on larynx cancer. CA Cancer J Clin. 67:31–50. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Forastiere AA, Ismaila N, Lewin JS, Nathan CA, Adelstein DJ, Eisbruch A, Fass G, Fisher SG, Laurie SA, Le QT, et al: Use of larynx-preservation strategies in the treatment of laryngeal cancer: American society of clinical oncology clinical practice guideline update. J Clin Oncol. 36:1143–1169. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Berrino F, De Angelis R, Sant M, Rosso S, Bielska-Lasota M, Coebergh JW and Santaquilani M; EUROCARE Working group, : Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: Results of the EUROCARE-4 study. Lancet Oncol. 8:773–783. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Forrest ME and Khalil AM: Review: Regulation of the cancer epigenome by long non-coding RNAs. Cancer Lett. 407:106–112. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Quinn JJ and Chang HY: Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 17:47–62. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Stein LD: Human genome: End of the beginning. Nature. 431:915–916. 2004. View Article : Google Scholar : PubMed/NCBI

9 

ENCODE Project Consortium, . An integrated encyclopedia of DNA elements in the human genome. Nature. 489:57–74. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Huang X, Zhou X, Hu Q, Sun B, Deng M, Qi X and Lü M: Advances in esophageal cancer: A new perspective on pathogenesis associated with long non-coding RNAs. Cancer Lett. 413:94–101. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Rinn JL and Chang HY: Genome regulation by long noncoding RNAs. Annu Rev Biochem. 81:145–616. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Flynn RA and Chang HY: Long noncoding RNAs in cell-fate programming and reprogramming. Cell Stem Cell. 14:752–761. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Gugnoni M and Ciarrocchi A: Long non-coding RNA and epithelial-mesenchymal transition in cance. Int J Mol Sci. 20:19242019. View Article : Google Scholar

14 

Tong Q, Shen Z, Li Q, Hao W and Zhou C: Expression and clinical significance of long non-coding RNA ac023794.4-201 in laryngeal squamous cell carcinoma. Chin Arch Otolaryngol Head Neck Surg. 10:564–566. 2018.(In Chinaese).

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Shen Z, Hao W, Zhou C, Deng H, Ye D, Li Q, Lin L, Cao B and Guo J: Long non-coding RNA AC026166.2-001 inhibits cell proliferation and migration in laryngeal squamous cell carcinoma by regulating the miR-24-3p/p27 axis. Sci Rep. 8:33752018. View Article : Google Scholar : PubMed/NCBI

17 

Yang S, Wang J, Ge W and Jiang Y: Long non-coding RNA LOC554202 promotes laryngeal squamous cell carcinoma progression through regulating miR-31. J Cell Biochem. 119:6953–6960. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Wu Y, Zhang L, Zhang L, Wang Y, Li H, Ren X, Wei F, Yu W, Liu T, Wang X, et al: Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. Int J Oncol. 46:2586–2594. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Chen G, Sun W, Hua X, Zeng W and Yang L: Long non-coding RNA FOXD2-AS1 aggravates nasopharyngeal carcinoma carcinogenesis by modulating miR-363-5p/S100A1 pathway. Gene. 645:76–84. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Zhang R, Hardin H, Huang W, Buehler D and Lloyd RV: Long non-coding RNA Linc-ror is upregulated in papillary thyroid carcinoma. Endocr Pathol. 29:1–8. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Liu M, Jia J, Wang X, Liu Y, Wang C and Fan R: Long non-coding RNA HOTAIR promotes cervical cancer progression through regulating BCL2 via targeting miR-143-3p. Cancer Biol Ther. 19:391–399. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Jia LF, Wei SB, Gan YH, Guo Y, Gong K, Mitchelson K, Cheng J and Yu GY: Expression, regulation and roles of miR-26a and MEG3 in tongue squamous cell carcinoma. Int J Cancer. 135:2282–2293. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Ensembl Genes. (DB/OL), . https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250432;r=12:5 4085132-54125992June 20–2019

24 

Shen Z, Li Q, Deng H, Lu D, Song H and Guo J: Long non-coding RNA profiling in laryngeal squamous cell carcinoma and its clinical significance: Potential biomarkers for LSCC. PLoS One. 9:e1082372014. View Article : Google Scholar : PubMed/NCBI

25 

Gioacchini FM, Alicandri-Ciufelli M, Magliulo G, Rubini C, Presutti L and Re M: The clinical relevance of Ki-67 expression in laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 272:1569–1576. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Jovanovic IP, Radosavljevic GD, Simovic-Markovic BJ, Stojanovic SP, Stefanovic SM, Pejnovic NN and Arsenijevic NN: Clinical significance of Cyclin D1, FGF3 and p21 protein expression in laryngeal squamous cell carcinoma. J BUON. 19:944–952. 2014.PubMed/NCBI

27 

Wang HX and Tang C: Galangin suppresses human laryngeal carcinoma via modulation of caspase-3 and AKT signaling pathways. Oncol Rep. 38:703–714. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Yang JQ, Liang Z, Wu M, Sun YM and Liu HX: Expression of p27 and PTEN and clinical characteristics in early laryngeal squamous cell carcinoma and their correlation with recurrence. Int J Clin Exp Pathol. 8:5715–5720. 2015.PubMed/NCBI

29 

Jobert L, Skjeldam HK, Dalhus B, Galashevskaya A, Vågbø CB, Bjørås M and Nilsen H: The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control. Mol Cell. 49:339–345. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Matsubara M, Tanaka T, Terato H and Ide H: Action mechanism of human SMUG1 uracil-DNA glycosylase. Nucleic Acids Symp Ser (Oxf). 49:295–296. 2005. View Article : Google Scholar

31 

Darwanto A, Theruvathu JA, Sowers JL, Rogstad DK, Pascal T, Goddard W III and Sowers LC: Mechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylase. J Biol Chem. 284:15835–15846. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Gong W, Tian M, Qiu H and Yang Z: Elevated serum level of lncRNA-HIF1A-AS1 as a novel diagnostic predictor for worse prognosis in colorectal carcinoma. Cancer Biomark. 20:417–424. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Chen X, Dai M, Zhu H, Li J, Huang Z, Liu X, Huang Y, Chen J and Dai S: Evaluation on the diagnostic and prognostic values of long non-coding RNA BLACAT1 in common types of human cancer. Mol Cancer. 16:1602017. View Article : Google Scholar : PubMed/NCBI

34 

Li W, Li N, Kang X and Shi K: Circulating long non-coding RNA AFAP1-AS1 is a potential diagnostic biomarker for non-small cell lung cancer. Clin Chim Acta. 475:152–156. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Wang J, Zhou Y, Lu J, Sun Y, Xiao H, Liu M and Tian L: Combined detection of serum exosomal miR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma. Med Oncol. 31:1482014. View Article : Google Scholar : PubMed/NCBI

36 

Madhavan B, Yue S, Galli U, Rana S, Gross W, Müller M, Giese NA, Kalthoff H, Becker T, Büchler MW and Zöller M: Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity. Int J Cancer. 136:616–627. 2015. View Article : Google Scholar

37 

Kachakova D, Mitkova A, Popov E, Popov I, Vlahova A, Dikov T, Christova S, Mitev V, Slavov C and Kaneva R: Combinations of serum prostate-specific antigen and plasma expression levels of let-7c, miR-30c, miR-141, and miR-375 as potential better diagnostic biomarkers for prostate cancer. DNA Cell Biol. 34:189–200. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shen Z, Yuan J, Tong Q, Hao W, Deng H, Li Q, Zhou C, Hu Y and Xu J: Long non‑coding RNA AC023794.4‑201 exerts a tumor‑suppressive function in laryngeal squamous cell cancer and may serve as a potential prognostic biomarker. Oncol Lett 20: 774-784, 2020.
APA
Shen, Z., Yuan, J., Tong, Q., Hao, W., Deng, H., Li, Q. ... Xu, J. (2020). Long non‑coding RNA AC023794.4‑201 exerts a tumor‑suppressive function in laryngeal squamous cell cancer and may serve as a potential prognostic biomarker. Oncology Letters, 20, 774-784. https://doi.org/10.3892/ol.2020.11595
MLA
Shen, Z., Yuan, J., Tong, Q., Hao, W., Deng, H., Li, Q., Zhou, C., Hu, Y., Xu, J."Long non‑coding RNA AC023794.4‑201 exerts a tumor‑suppressive function in laryngeal squamous cell cancer and may serve as a potential prognostic biomarker". Oncology Letters 20.1 (2020): 774-784.
Chicago
Shen, Z., Yuan, J., Tong, Q., Hao, W., Deng, H., Li, Q., Zhou, C., Hu, Y., Xu, J."Long non‑coding RNA AC023794.4‑201 exerts a tumor‑suppressive function in laryngeal squamous cell cancer and may serve as a potential prognostic biomarker". Oncology Letters 20, no. 1 (2020): 774-784. https://doi.org/10.3892/ol.2020.11595
Copy and paste a formatted citation
x
Spandidos Publications style
Shen Z, Yuan J, Tong Q, Hao W, Deng H, Li Q, Zhou C, Hu Y and Xu J: Long non‑coding RNA AC023794.4‑201 exerts a tumor‑suppressive function in laryngeal squamous cell cancer and may serve as a potential prognostic biomarker. Oncol Lett 20: 774-784, 2020.
APA
Shen, Z., Yuan, J., Tong, Q., Hao, W., Deng, H., Li, Q. ... Xu, J. (2020). Long non‑coding RNA AC023794.4‑201 exerts a tumor‑suppressive function in laryngeal squamous cell cancer and may serve as a potential prognostic biomarker. Oncology Letters, 20, 774-784. https://doi.org/10.3892/ol.2020.11595
MLA
Shen, Z., Yuan, J., Tong, Q., Hao, W., Deng, H., Li, Q., Zhou, C., Hu, Y., Xu, J."Long non‑coding RNA AC023794.4‑201 exerts a tumor‑suppressive function in laryngeal squamous cell cancer and may serve as a potential prognostic biomarker". Oncology Letters 20.1 (2020): 774-784.
Chicago
Shen, Z., Yuan, J., Tong, Q., Hao, W., Deng, H., Li, Q., Zhou, C., Hu, Y., Xu, J."Long non‑coding RNA AC023794.4‑201 exerts a tumor‑suppressive function in laryngeal squamous cell cancer and may serve as a potential prognostic biomarker". Oncology Letters 20, no. 1 (2020): 774-784. https://doi.org/10.3892/ol.2020.11595
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team