Salvia bowleyana Dunn root is a novel source of salvianolic acid B and displays antitumor effects against gastric cancer cells

Chen,Binghua; Huang,Chaoqun; Zhang,Yuanyan; Tang,Xiaoqiong; Li,Suhuan; Wang,Qingshui; Lin,Yao

doi:10.3892/ol.2020.11611

Salvia bowleyana Dunn root is a novel source of salvianolic acid B and displays antitumor effects against gastric cancer cells

Authors:
- Binghua Chen
- Chaoqun Huang
- Yuanyan Zhang
- Xiaoqiong Tang
- Suhuan Li
- Qingshui Wang
- Yao Lin
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Affiliations: College of Life Sciences, Fujian Normal University, Fuzhou, Fujian 350117, P.R. China
Published online on: May 13, 2020 https://doi.org/10.3892/ol.2020.11611
Pages: 817-827
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Salvianolic acid B (Sal-B) is widely used in China for the treatment of numerous diseases. Currently, Salvia miltiorrhiza Bunge is the main source of this compound, but Salvia bowleyana Dunn, a surrogate of S. miltiorrhiza Bge, may provide a novel source for obtaining more Sal‑B. In the present study, a simple method for separation and purification of phenolic compounds from S. bowleyana Dunn roots was employed. Sal‑B was subsequently purified and its inhibitory effect on the gastric cancer HGC‑27 and AGS cell lines was investigated. Sal‑B extracted from S. bowleyana Dunn displayed significant antitumor activity in proliferation and apoptosis assays. Overall, it was found that S. bowleyana Dunn has a higher Sal‑B content than S. miltiorrhiza Bge and may be used as a novel source of this potential anti‑gastric cancer compound.

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