Open Access

Signal transducer and activator of transcription 6 as a target in colon cancer therapy (Review)

  • Authors:
    • Yael Delgado‑Ramirez
    • Vaneesa Colly
    • Giovanni Villanueva Gonzalez
    • Sonia Leon‑Cabrera
  • View Affiliations

  • Published online on: May 13, 2020     https://doi.org/10.3892/ol.2020.11614
  • Pages: 455-464
  • Copyright: © Delgado‑Ramirez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family of proteins that serve key roles in the initiation of tumorigenesis and malignant transformation. STAT6 is highly expressed in several types of cancer, including breast, pancreatic, prostate and colorectal cancer. STAT6 transduces signals in response to the binding of interleukin (IL)‑4 and IL‑13 to their receptors and regulates the expression of genes involved in the immune response, cell survival, tumor proliferation and metastasis. Patients with colorectal cancer exhibit high STAT6 activity in the colonic epithelium, and STAT6 expression is associated with lower survival rates, lymph node metastasis, changes in the epithelial barrier function and alterations in the inflammatory response. A number of studies investigating experimental models and cancer cell lines have revealed that STAT6 is associated with tumor growth and development, as well as with increased invasion and metastasis, suggesting that STAT6 inhibition may serve as a novel therapeutic strategy in colon cancer. The present review summarizes the evidence with regard to the implications of STAT6 in cancer biology and the direct and indirect effects on colon tumor transformation. Furthermore, the current treatment strategies targeting the IL‑4/IL‑13/STAT6 axis in colon cancer are discussed.

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July 2020
Volume 20 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Delgado‑Ramirez, Y., Colly, V., Villanueva Gonzalez, G., & Leon‑Cabrera, S. (2020). Signal transducer and activator of transcription 6 as a target in colon cancer therapy (Review). Oncology Letters, 20, 455-464. https://doi.org/10.3892/ol.2020.11614
MLA
Delgado‑Ramirez, Y., Colly, V., Villanueva Gonzalez, G., Leon‑Cabrera, S."Signal transducer and activator of transcription 6 as a target in colon cancer therapy (Review)". Oncology Letters 20.1 (2020): 455-464.
Chicago
Delgado‑Ramirez, Y., Colly, V., Villanueva Gonzalez, G., Leon‑Cabrera, S."Signal transducer and activator of transcription 6 as a target in colon cancer therapy (Review)". Oncology Letters 20, no. 1 (2020): 455-464. https://doi.org/10.3892/ol.2020.11614