Open Access

Prognostic significance of high triglyceride and apolipoprotein B levels in patients with stage III and high-risk stage II colorectal cancer undergoing curative surgery

  • Authors:
    • Xiu-Qing Chen
    • Pei-Wen Wu
    • Dong-Hui Liu
    • Sun-Jie Yan
    • Xi-Mei Shen
    • Li-Yong Yang
  • View Affiliations

  • Published online on: May 13, 2020     https://doi.org/10.3892/ol.2020.11617
  • Pages: 705-714
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Although epidemiologic studies suggest that dyslipidemia increases the risk of colorectal cancer (CRC), the prognostic value of blood lipid and apolipoprotein levels in CRC remains unclear. The aim of the present study was to investigate the impact of blood lipid and apolipoprotein levels on the prognosis of patients with stage III and high‑risk stage II CRC undergoing curative surgery. Preoperative levels of total cholesterol, triglycerides (TG), high‑density lipoprotein, low‑density lipoprotein, very‑low‑density lipoprotein, apolipoprotein A1 and apolipoprotein B (APO‑B) in patients with CRC undergoing surgery were evaluated. The cut‑off values of these factors were determined by the maximal x2 method and were used to classify patients into two prognostic groups: Poor and good prognosis groups. The patients' prognostic values were assessed using the Kaplan‑Meier curve and Cox regression analysis. In addition, the impact of these parameters on the prognosis and their predictive accuracy were evaluated using nomograms and Harrell's concordance index, respectively. In total, 246 patients were included in this evaluation. Based on the cut‑off points for TG (1.53 mmol/l in men and 1.58 mmol/l in women) and APO‑B (0.73 mmol/l in men and women), the present study determined that both TG and APO‑B were predictors of disease‑free survival (DFS) and overall survival (OS). Multivariate analysis demonstrated that high TG (men, ≥1.53 mmol/l; women, ≥1.58 mmol/l) and high APO‑B (≥0.73 mmol/l) levels were significantly associated with decreased DFS and OS. Nomograms that included values for TG and APO‑B levels demonstrated higher predictive accuracy compared with that of nomograms without these values. These results indicated that TG and APO‑B levels may be good independent prognostic biomarkers after radical CRC surgery. Therefore, adjusting these parameters to moderate levels may be beneficial.

Related Articles

Journal Cover

July 2020
Volume 20 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Chen, X., Wu, P., Liu, D., Yan, S., Shen, X., & Yang, L. (2020). Prognostic significance of high triglyceride and apolipoprotein B levels in patients with stage III and high-risk stage II colorectal cancer undergoing curative surgery. Oncology Letters, 20, 705-714. https://doi.org/10.3892/ol.2020.11617
MLA
Chen, X., Wu, P., Liu, D., Yan, S., Shen, X., Yang, L."Prognostic significance of high triglyceride and apolipoprotein B levels in patients with stage III and high-risk stage II colorectal cancer undergoing curative surgery". Oncology Letters 20.1 (2020): 705-714.
Chicago
Chen, X., Wu, P., Liu, D., Yan, S., Shen, X., Yang, L."Prognostic significance of high triglyceride and apolipoprotein B levels in patients with stage III and high-risk stage II colorectal cancer undergoing curative surgery". Oncology Letters 20, no. 1 (2020): 705-714. https://doi.org/10.3892/ol.2020.11617