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Antitumor immunity targeting fibroblast activation protein‑α in a mouse Lewis lung carcinoma model

  • Authors:
    • Junping Xie
    • Shiyang Yuan
    • Laishui Peng
    • Huanyu Li
    • Linxia Niu
    • Hui Xu
    • Xiaolin Guo
    • Mei Yang
    • Fengying Duan
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 868-876
    |
    Published online on: May 18, 2020
       https://doi.org/10.3892/ol.2020.11637
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Abstract

The tumor stromal microenvironment is an integral part of the occurrence and development of tumor. Cancer‑associated fibroblasts (CAFs) are a key component of most tumor stromal microenvironments. The present study aimed to investigate the use of CAFs‑targeted immunotherapy to fibroblast activation protein‑α (FAP‑α) expressed in CAFs. Recombinant adenoviral vectors containing the mouse FAP‑α cDNA (rAd‑FAP‑α) were constructed. C57BL/6 mice were immunized with rAd‑FAP‑α infected dendritic cells (DCs) against FAP‑α, which is overexpress in CAFs. The results demonstrated that mice vaccinated with rAd‑FAP‑α DCs gave rise to potent FAP‑α‑specific cytotoxic T lymphocytes capable of lysing Lewis lung cancer (LLC) CAFs. Furthermore, mice vaccinated with rAd‑FAP‑α‑transduced DCs induced an effective therapeutic or protective antitumor immunity to LLC in a subcutaneous model, and prolonged overall survival time compared with mice vaccinated with the control recombinant adenovirus‑transduced DCs (rAd‑c DCs) or DCs alone. The results of the present study suggested that FAP‑α, which is preferentially expressed in CAFs, may be considered as a potential target for killing or destroying CAFs within the tumor stromal microenvironment, and may be exploited to develop immunogenic tumor vaccines.
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1 

Lai D, Ma L and Wang F: Fibroblast activation protein regulates tumor-associated fibroblasts and epithelial ovarian cancer cells. Int J Oncol. 41:541–550. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Giannoni E, Bianchini F, Calorini L and Chiarugi P: Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness. Antioxid Redox Signal. 14:2361–2371. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Puré E and Lo A: Can targeting stroma pave the way to enhanced antitumor immunity and immunotherapy of solid tumors? Cancer Immunol Res. 4:269–278. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Liu T, Zhou L, Li D, Andl T and Zhang Y: Cancer-associated fibroblasts build and secure the tumor microenvironment. Front Cell Dev Biol. 7:602019. View Article : Google Scholar : PubMed/NCBI

5 

Erez N, Truitt M, Olson P, Arron ST and Hanahan D: Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell. 17:135–147. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Ohshio Y, Teramoto K, Hanaoka J, Tezuka N, Itoh Y, Asai T, Daigo Y and Ogasawara K: Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine. Cancer Sci. 106:134–142. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Barron DA and Rowley DR: The reactive stroma microenvironment and prostate cancer progression. Endocr Relat Cancer. 19:R187–R204. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Gascard P and Tlsty TD: Carcinoma-associated fibroblasts: Orchestrating the composition of malignancy. Genes Dev. 30:1002–1019. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Valkenburg KC, de Groot AE and Pienta KJ: Targeting the tumour stroma to improve cancer therapy. Nat Rev Clin Oncol. 15:366–381. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Elenbaas B and Weinberg RA: Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp Cell Res. 264:169–184. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Xing F, Saidou J and Watabe K: Cancer associated fibroblasts (CAFs) in tumor microenvironment. Front Biosci (Landmark Ed). 15:166–179. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Bhowmick NA, Neilson EG and Moses HL: Stromal fibroblasts in cancer initiation and progression. Nature. 432:332–337. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Santos AM, Jung J, Aziz N, Kissil JL and Puré E: Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest. 119:3613–3625. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Edosada CY, Quan C, Tran T, Pham V, Wiesmann C, Fairbrother W and Wolf BB: Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity. FEBS Lett. 580:1581–1586. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Edosada CY, Quan C, Wiesmann C, Tran T, Sutherlin D, Reynolds M, Elliott JM, Raab H, Fairbrother W and Wolf BB: Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity. J Biol Chem. 281:7437–7444. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Jansen K, Heirbaut L, Cheng JD, Joossens J, Ryabtsova O, Cos P, Maes L, Lambeir AM, De Meester I, Augustyns K, et al: Selective inhibitors of fibroblast activation protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine scaffold. ACS Med Chem Lett. 4:491–496. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Meadows SA, Edosada CY, Mayeda M, Tran T, Quan C, Raab H, Wiesmann C and Wolf BB: Ala657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization. Biochemistry. 46:4598–4605. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Ostermann E, Garin-Chesa P, Heider KH, Kalat M, Lamche H, Puri C, Kerjaschki D, Rettig WJ and Adolf GR: Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts. Clin Cancer Res. 14:4584–4592. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Jia J, Martin TA, Ye L and Jiang WG: FAP-α (Fibroblast activation protein-α) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway. BMC Cell Biol. 15:162014. View Article : Google Scholar : PubMed/NCBI

20 

Nyberg-Hoffman C, Shabram P, Li W, Giroux D and Aguilar-Cordova E: Sensitivity and reproducibility in adenoviral infectious titer determination. Nat Med. 3:808–811. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Xie J, Xiong L, Tao X, Li X, Su Y, Hou X and Shi H: Antitumor effects of murine bone marrow-derived dendritic cells infected with xenogeneic livin alpha recombinant adenoviral vectors against lewis lung carcinoma. Lung Cancer. 68:338–345. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Lee J, Fassnacht M, Nair S, Boczkowski D and Gilboa E: Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts. Cancer Res. 65:11156–11163. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Puré E and Blomberg R: Pro-tumorigenic roles of fibroblast activation protein in cancer: Back to the basics. Oncogene. 37:4343–4357. 2018. View Article : Google Scholar : PubMed/NCBI

24 

van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A and Boon T: A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science. 254:1643–1647. 1991. View Article : Google Scholar : PubMed/NCBI

25 

Willimsky G, Czéh M, Loddenkemper C, Gellermann J, Schmidt K, Wust P, Stein H and Blankenstein T: Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness. J Exp Med. 205:1687–1700. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Dunn GP, Koebel CM and Schreiber RD: Interferons, immunity and cancer immunoediting. Nat Rev Immunol. 6:836–848. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Speiser DE, Baumgaertner P, Barbey C, Rubio-Godoy V, Moulin A, Corthesy P, Devevre E, Dietrich PY, Rimoldi D, Liénard D, et al: A novel approach to characterize clonality and differentiation of human melanoma-specific T cell responses: Spontaneous priming and efficient boosting by vaccination. J Immunol. 177:1338–1348. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Rosenberg SA, Sherry RM, Morton KE, Scharfman WJ, Yang JC, Topalian SL, Royal RE, Kammula U, Restifo NP, Hughes MS, et al: Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8 + T cells in patients with melanoma. J Immunol. 175:6169–6176. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Valmori D, Souleimanian NE, Tosello V, Bhardwaj N, Adams S, O'Neill D, Pavlick A, Escalon JB, Cruz CM, Angiulli A, et al: Vaccination with NY-ESO-1 protein and CpG in montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming. Proc Natl Acad Sci USA. 104:8947–8952. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Garin-Chesa P, Old LJ and Rettig WJ: Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers. Proc Natl Acad Sci USA. 87:7235–7239. 1990. View Article : Google Scholar : PubMed/NCBI

31 

Dolznig H, Schweifer N, Puri C, Kraut N, Rettig WJ, Kerjaschki D and Garin-Chesa P: Characterization of cancer stroma markers: In silico analysis of an mRNA expression database for fibroblast activation protein and endosialin. Cancer Immun. 5:102005.PubMed/NCBI

32 

Scarfò I and Maus MV: Current approaches to increase CAR T cell potency in solid tumors: Targeting the tumor microenvironment. J Immunother Cancer. 5:282017. View Article : Google Scholar : PubMed/NCBI

33 

Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL and Weinberg RA: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 121:335–348. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Chen WT and Kelly T: Seprase complexes in cellular invasiveness. Cancer Metastasis Rev. 22:259–269. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Rosenblum JS and Kozarich JW: Prolyl peptidases: A serine protease subfamily with high potential for drug discovery. Curr Opin Chem Biol. 7:496–504. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Hofheinz RD, al-Batran SE, Hartmann F, Hartung G, Jäger D, Renner C, Tanswell P, Kunz U, Amelsberg A, Kuthan H and Stehle G: Stromal antigen targeting by a humanised monoclonal antibody: An early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer. Onkologie. 26:44–48. 2003.PubMed/NCBI

37 

Scott AM, Wiseman G, Welt S, Adjei A, Lee FT, Hopkins W, Divgi CR, Hanson LH, Mitchell P, Gansen DN, et al: A phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin Cancer Res. 9:1639–1647. 2003.PubMed/NCBI

38 

Kawase T, Yasui Y, Nishina S, Hara Y, Yanatori I, Tomiyama Y, Nakashima Y, Yoshida K, Kishi F, Nakamura M and Hino K: Fibroblast activation protein-α-expressing fibroblasts promote the progression of pancreatic ductal adenocarcinoma. BMC Gastroenterol. 15:1092015. View Article : Google Scholar : PubMed/NCBI

39 

Brennen WN, Rosen DM, Wang H, Isaacs JT and Denmeade SR: Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug. J Natl Cancer Inst. 104:1320–1334. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Schreiber H and Rowley DA: Cancer. Awakening immunity. Science. 330:761–762. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Kraman M, Bambrough PJ, Arnold JN, Roberts EW, Magiera L, Jones JO, Gopinathan A, Tuveson DA and Fearon DT: Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science. 330:827–830. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xie J, Yuan S, Peng L, Li H, Niu L, Xu H, Guo X, Yang M and Duan F: Antitumor immunity targeting fibroblast activation protein‑α in a mouse Lewis lung carcinoma model. Oncol Lett 20: 868-876, 2020.
APA
Xie, J., Yuan, S., Peng, L., Li, H., Niu, L., Xu, H. ... Duan, F. (2020). Antitumor immunity targeting fibroblast activation protein‑α in a mouse Lewis lung carcinoma model. Oncology Letters, 20, 868-876. https://doi.org/10.3892/ol.2020.11637
MLA
Xie, J., Yuan, S., Peng, L., Li, H., Niu, L., Xu, H., Guo, X., Yang, M., Duan, F."Antitumor immunity targeting fibroblast activation protein‑α in a mouse Lewis lung carcinoma model". Oncology Letters 20.1 (2020): 868-876.
Chicago
Xie, J., Yuan, S., Peng, L., Li, H., Niu, L., Xu, H., Guo, X., Yang, M., Duan, F."Antitumor immunity targeting fibroblast activation protein‑α in a mouse Lewis lung carcinoma model". Oncology Letters 20, no. 1 (2020): 868-876. https://doi.org/10.3892/ol.2020.11637
Copy and paste a formatted citation
x
Spandidos Publications style
Xie J, Yuan S, Peng L, Li H, Niu L, Xu H, Guo X, Yang M and Duan F: Antitumor immunity targeting fibroblast activation protein‑α in a mouse Lewis lung carcinoma model. Oncol Lett 20: 868-876, 2020.
APA
Xie, J., Yuan, S., Peng, L., Li, H., Niu, L., Xu, H. ... Duan, F. (2020). Antitumor immunity targeting fibroblast activation protein‑α in a mouse Lewis lung carcinoma model. Oncology Letters, 20, 868-876. https://doi.org/10.3892/ol.2020.11637
MLA
Xie, J., Yuan, S., Peng, L., Li, H., Niu, L., Xu, H., Guo, X., Yang, M., Duan, F."Antitumor immunity targeting fibroblast activation protein‑α in a mouse Lewis lung carcinoma model". Oncology Letters 20.1 (2020): 868-876.
Chicago
Xie, J., Yuan, S., Peng, L., Li, H., Niu, L., Xu, H., Guo, X., Yang, M., Duan, F."Antitumor immunity targeting fibroblast activation protein‑α in a mouse Lewis lung carcinoma model". Oncology Letters 20, no. 1 (2020): 868-876. https://doi.org/10.3892/ol.2020.11637
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