Open Access

Long non‑coding RNA RFPL3S is a novel prognostic biomarker in lung cancer

  • Authors:
    • Zhonghua Liu
    • Zhiqiang Ning
    • Hailin Lu
    • Tinghua Cao
    • Feng Zhou
    • Xia Ye
    • Chao Chen
  • View Affiliations

  • Published online on: May 19, 2020     https://doi.org/10.3892/ol.2020.11642
  • Pages: 1270-1280
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs (lncRNAs) are functional components of the human genome. Recent studies have demonstrated that lncRNAs play essential roles in tumorigenesis, and are involved in cell proliferation, apoptosis, migration and invasion in several types of tumor, including lung cancer. However, the clinical relevance of lncRNA expression in lung cancer remains unknown. The aim of the present study was to investigate the expression pattern of RFPL3 antisense (RFPL3S) and its associations with clinicopathological characteristics in patients with lung cancer. Whether RFPL3S can act as a potential prognostic biomarker for lung cancer was also investigated. RFPL3S expression in tumor samples and cells was assessed using the Oncomine database and the Cancer Cell Line Encyclopedia, respectively. Based on Kaplan‑Meier Plotter analyses, the prognostic values of RFPL3S were further evaluated. It was revealed that RFPL3S was highly expressed in lung cancer tissues when compared with normal tissues and was significantly associated with pN factor, pTNM stage and Ki‑67 labeling index. In the survival analyses, increased RFPL3S expression was associated with poor survival and was inversely associated with first progression in all patients. These results indicate that RFPL3S may be of clinical significance and may act as a prognostic biomarker in lung cancer.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu Z, Ning Z, Lu H, Cao T, Zhou F, Ye X and Chen C: Long non‑coding RNA RFPL3S is a novel prognostic biomarker in lung cancer. Oncol Lett 20: 1270-1280, 2020
APA
Liu, Z., Ning, Z., Lu, H., Cao, T., Zhou, F., Ye, X., & Chen, C. (2020). Long non‑coding RNA RFPL3S is a novel prognostic biomarker in lung cancer. Oncology Letters, 20, 1270-1280. https://doi.org/10.3892/ol.2020.11642
MLA
Liu, Z., Ning, Z., Lu, H., Cao, T., Zhou, F., Ye, X., Chen, C."Long non‑coding RNA RFPL3S is a novel prognostic biomarker in lung cancer". Oncology Letters 20.2 (2020): 1270-1280.
Chicago
Liu, Z., Ning, Z., Lu, H., Cao, T., Zhou, F., Ye, X., Chen, C."Long non‑coding RNA RFPL3S is a novel prognostic biomarker in lung cancer". Oncology Letters 20, no. 2 (2020): 1270-1280. https://doi.org/10.3892/ol.2020.11642