Role of ubiquitin‑conjugating enzyme E2T in the carcinogenesis and progression of pancreatic cancer

  • Authors:
    • Yuan‑Wen Zheng
    • Peng‑Fei Gao
    • Ming‑Ze Ma
    • Yong Chen
    • Chun‑You Li
  • View Affiliations

  • Published online on: May 19, 2020     https://doi.org/10.3892/ol.2020.11644
  • Pages: 1462-1468
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Abstract

Ubiquitin-conjugating enzyme E2T (UBE2T) is a recently discovered oncogenic protein. Numerous studies reported that UBE2T is highly expressed in various types of human cancer; however, its role in the carcinogenesis and progression of pancreatic cancer remains unknown. The aim of the present study was to investigate the role of UBE2T in pancreatic cancer progression through in vitro experiments in pancreatic cancer tissues and cell lines. The results obtained in the present study demonstrated that UBE2T served an important role in the initiation and progression of pancreatic cancer. Furthermore, increased expression of UBE2T in human pancreatic cancer tissues and pancreatic cancer cells was observed compared with normal tissues and cells. The effect of upregulating and downregulating UBE2T in pancreatic cancer cell lines was investigated using the MTT, wound‑healing and migration and invasion assays. The results demonstrated that overexpression of UBE2T significantly promoted pancreatic cancer cell proliferation, migration and invasion compared with controls. However, UBE2T downregulation resulted in the inhibition of pancreatic cancer cell proliferation, migration and invasion. In addition, the results demonstrated that UBE2T may promote the epithelial mesenchymal transition in pancreatic cancer cells.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zheng, Y., Gao, P., Ma, M., Chen, Y., & Li, C. (2020). Role of ubiquitin‑conjugating enzyme E2T in the carcinogenesis and progression of pancreatic cancer. Oncology Letters, 20, 1462-1468. https://doi.org/10.3892/ol.2020.11644
MLA
Zheng, Y., Gao, P., Ma, M., Chen, Y., Li, C."Role of ubiquitin‑conjugating enzyme E2T in the carcinogenesis and progression of pancreatic cancer". Oncology Letters 20.2 (2020): 1462-1468.
Chicago
Zheng, Y., Gao, P., Ma, M., Chen, Y., Li, C."Role of ubiquitin‑conjugating enzyme E2T in the carcinogenesis and progression of pancreatic cancer". Oncology Letters 20, no. 2 (2020): 1462-1468. https://doi.org/10.3892/ol.2020.11644