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PD‑L1 expression increased by IFN‑γ via JAK2‑STAT1 signaling and predicts a poor survival in colorectal cancer

  • Authors:
    • Tiancheng Zhao
    • Yezhou Li
    • Jiayu Zhang
    • Bin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Endoscopy Center, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Vascular Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Gastrointestinal Colorectal and Anal Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1127-1134
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    Published online on: May 20, 2020
       https://doi.org/10.3892/ol.2020.11647
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Abstract

PD‑L1 inhibitors are widely used in tumor immunotherapy, but their mechanism in colorectal cancer remains unclear. The present study aimed to investigate the mechanisms underlying programmed death ligand 1 (PD‑L1) regulation via the interferon‑γ (IFN‑γ)/janus kinase (JAK)/STAT signaling pathway, and its prognostic value in patients with colorectal cancer (CRC). A cohort of 181 patients were recruited to determine the association between PD‑L1 expression and CRC prognosis; the patients were newly diagnosed with colorectal adenocarcinoma and had also undergone a physical tumorectomy. Immunohistochemical staining and survival analysis were used to evaluate the predictive value of PD‑L1 protein expression in CRC. Gene set enrichment analysis, RT‑qPCR and western blotting, etc were performed to confirm that PD‑L1 is regulated by the IFN‑γ/JAK/STAT signaling pathway. PD‑L1 up‑regulation was more frequently observed in patients with larger tumors, positive vascular or lymphatic infiltration and a poorly differentiated stage in addition to being associated with a poor survival in patients with CRC. Following the stimulation with IFN‑γ, PD‑L1 expression levels were revealed to be increased via the JAK2/STAT1 signaling pathway. In conclusion, the findings of the present study indicated that the expression levels of PD‑L1 may be associated with a poor prognosis in patients with CRC. In addition, the results suggested that the IFN‑γ‑mediated overexpression of PD‑L1 in CRC cells may be regulated by the JAK2/STAT1 signaling pathway.
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Maida M, Macaluso FS, Ianiro G, Mangiola F, Sinagra E, Hold G, Maida C, Cammarota G, Gasbarrini A and Scarpulla G: Screening of colorectal cancer: Present and future. Expert Rev Anticancer Ther. 17:1131–1146. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Binefa G, Rodriguez-Moranta F, Teule A and Medina-Hayas M: Colorectal cancer: From prevention to personalized medicine. World J Gastroenterol. 20:6786–6808. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Tapia Rico G, Townsend AR, Broadbridge V and Price TJ: Targeted therapies in elderly patients with metastatic colorectal cancer: A review of the evidence. Drugs Aging. 34:173–189. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Passardi A, Canale M, Valgiusti M and Ulivi P: Immune checkpoints as a target for colorectal cancer treatment. Int J Mol Sci. 18:E13242017. View Article : Google Scholar : PubMed/NCBI

6 

Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T and Minato N: Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci USA. 99:12293–12297. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Wu Y, Cao D, Qu L, Cao X, Jia Z, Zhao T, Wang Q and Jiang J: PD-1 and PD-L1 co-expression predicts favorable prognosis in gastric cancer. Oncotarget. 8:64066–64082. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Song P, Cui X, Bai L, Zhou X, Zhu X, Zhang J, Jin F, Zhao J, Zhou C, Zhou Y, et al: Molecular characterization of clinical responses to PD-1/PD-L1 inhibitors in non-small cell lung cancer: Predictive value of multidimensional immunomarker detection for the efficacy of PD-1 inhibitors in Chinese patients. Thorac Cancer. 10:1303–1309. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Li S, Chen L and Jiang J: Role of programmed cell death ligand-1 expression on prognostic and overall survival of breast cancer: A systematic review and meta-analysis. Medicine (Baltimore). 98:e152012019. View Article : Google Scholar : PubMed/NCBI

10 

Li Y, He M, Zhou Y, Yang C, Wei S, Bian X, Christopher O and Xie L: The prognostic and clinicopathological roles of PD-L1 expression in colorectal cancer: A systematic review and meta-analysis. Front Pharmacol. 10:1392019. View Article : Google Scholar : PubMed/NCBI

11 

Yaghoubi N, Soltani A, Ghazvini K, Hassanian SM and Hashemy SI: PD-1/PD-L1 blockade as a novel treatment for colorectal cancer. Biomed Pharmacother. 110:312–318. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Ng HY, Li J, Tao L, Lam AK, Chan KW, Ko JMY, Yu VZ, Wong M, Li B and Lung ML: Chemotherapeutic treatments increase PD-L1 expression in esophageal squamous cell carcinoma through EGFR/ERK activation. Transl Oncol. 11:1323–1333. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Mimura K, Teh JL, Okayama H, Shiraishi K, Kua LF, Koh V, Smoot DT, Ashktorab H, Oike T, Suzuki Y, et al: PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer. Cancer Sci. 109:43–53. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Qin X, Liu C, Zhou Y and Wang G: Cisplatin induces programmed death-1-ligand 1(PD-L1) over-expression in hepatoma H22 cells via Erk/MAPK signaling pathway. Cell Mol Biol (Noisy-le-grand). 11:OL1366–OL1372. 2010.

15 

Bellucci R, Martin A, Bommarito D, Wang K, Hansen SH, Freeman GJ and Ritz J: Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression. Oncoimmunology. 4:e10088242015. View Article : Google Scholar : PubMed/NCBI

16 

Imai D, Yoshizumi T, Okano S, Itoh S, Ikegami T, Harada N, Aishima S, Oda Y and Maehara Y: IFN-γ promotes epithelial-mesenchymal transition and the expression of PD-L1 in pancreatic cancer. J Surg Res. 240:115–123. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P, Washington KM, Carneiro F and Cree IA; WHO Classification of Tumours Editorial Board, : The 2019 WHO classification of tumours of the digestive system. Histopathology. 76:182–188. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Cuccurullo V and Mansi L: AJCC Cancer staging Handbook: From the AJCC cancer staging manual (7th edition). Eur J Nucl Med Mol Imaging. 38:408. 2011. View Article : Google Scholar

19 

Cancer Genome Atlas Network: Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487:330–337. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

21 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45:D353–D361. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Zhu H, Qin H, Huang Z, Li S, Zhu X, He J, Yang J, Yu X and Yi X: Clinical significance of programmed death ligand-1 (PD-L1) in colorectal serrated adenocarcinoma. Int J Clin Exp Pathol. 8:9351–9359. 2015.PubMed/NCBI

25 

Enkhbat T, Nishi M, Takasu C, Yoshikawa K, Jun H, Tokunaga T, Kashihara H, Ishikawa D and Shimada M: Programmed cell death ligand 1 expression is an independent prognostic factor in colorectal cancer. Anticancer Res. 38:3367–3373. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Liu R, Peng K, Yu Y, Liang L, Xu X, Li W, Yu S and Liu T: Prognostic value of immunoscore and PD-L1 expression in metastatic colorectal cancer patients with different RAS status after palliative operation. Biomed Res Int. 2018:59206082018.PubMed/NCBI

27 

Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK and Sharpe AH: PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 206:3015–3029. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Carretero-Gonzalez A, Lora D, Ghanem I, Zugazagoitia J, Castellano D, Sepúlveda JM, López-Martin JA, Paz-Ares L and de Velasco G: Analysis of response rate with ANTI PD1/PD-L1 monoclonal antibodies in advanced solid tumors: A meta-analysis of randomized clinical trials. Oncotarget. 9:8706–8715. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Asaoka Y, Ijichi H and Koike K: PD-1 Blockade in tumors with mismatch-repair deficiency. N Engl J Med. 373:19792015. View Article : Google Scholar : PubMed/NCBI

30 

O'Neil BH, Wallmark J, Lorente D, Elez E, Raimbourg J, Gomez-Roca C, Ejadi S, Piha-Paul SA, Moss RA, Siu LL, et al: Pembrolizumab (MK-3475) for patients (pts) with advanced colorectal carcinoma (CRC): Preliminary results from KEYNOTE-028. Eur J Cancer. 51:4332015. View Article : Google Scholar

31 

Concha-Benavente F, Srivastava RM, Trivedi S, Lei Y, Chandran U, Seethala RR, Freeman GJ and Ferris RL: Identification of the cell-intrinsic and -extrinsic pathways downstream of EGFR and IFNγ that induce PD-L1 expression in head and neck cancer. Cancer Res. 76:1031–1043. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Li Y, Liang L, Dai W, Cai G, Xu Y, Li X, Li Q and Cai S: Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer. Mol Cancer. 15:552016. View Article : Google Scholar : PubMed/NCBI

33 

Kong P, Wang J, Song Z, Liu S, He W, Jiang C, Xie Q, Yang L, Xia X and Xia L: Circulating lymphocytes, PD-L1 expression on tumor-infiltrating lymphocytes, and survival of colorectal cancer patients with different mismatch repair gene status. J Cancer. 10:1745–1754. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Calik I, Calik M, Turken G, Ozercan IH, Dagli AF, Artas G and Sarikaya B: Intratumoral cytotoxic T-lymphocyte density and PD-L1 expression are prognostic biomarkers for patients with colorectal cancer. Medicina (Kaunas). 55:E7232019. View Article : Google Scholar : PubMed/NCBI

35 

Sudoyo AW, Kurniawan AN, Kusumo GD, Putra TP, Rexana FA, Yunus M, Budiyati AD, Kurniawan D, Utama A and Utomo AR: Increased CD8 tumor infiltrating lymphocytes in colorectal cancer microenvironment supports an adaptive immune resistance mechanism of PD-L1 expression. Asian Pac J Cancer Prev. 20:3421–3427. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Meyer SC: Mechanisms of resistance to JAK2 inhibitors in myeloproliferative neoplasms. Hematol Oncol Clin North Am. 31:627–642. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Gotthardt D, Putz EM, Grundschober E, Prchal-Murphy M, Straka E, Kudweis P, Heller G, Bago-Horvath Z, Witalisz-Siepracka A, Cumaraswamy AA, et al: STAT5 is a key regulator in NK cells and acts as a molecular switch from tumor surveillance to tumor promotion. Cancer Discov. 6:414–429. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Valentini AM, Di Pinto F, Cariola F, Guerra V, Giannelli G, Caruso ML and Pirrelli M: PD-L1 expression in colorectal cancer defines three subsets of tumor immune microenvironments. Oncotarget. 9:8584–8596. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Oliveira AF, Bretes L and Furtado I: Review of PD-1/PD-L1 inhibitors in metastatic dMMR/MSI-H colorectal cancer. Front Oncol. 9:3962019. View Article : Google Scholar : PubMed/NCBI

40 

Angell HK, Lee J, Kim KM, Kim K, Kim ST, Park SH, Kang WK, Sharpe A, Ogden J, Davenport A, et al: PD-L1 and immune infiltrates are differentially expressed in distinct subgroups of gastric cancer. Oncoimmunology. 8:e15444422019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao T, Li Y, Zhang J and Zhang B: PD‑L1 expression increased by IFN‑γ via JAK2‑STAT1 signaling and predicts a poor survival in colorectal cancer. Oncol Lett 20: 1127-1134, 2020.
APA
Zhao, T., Li, Y., Zhang, J., & Zhang, B. (2020). PD‑L1 expression increased by IFN‑γ via JAK2‑STAT1 signaling and predicts a poor survival in colorectal cancer. Oncology Letters, 20, 1127-1134. https://doi.org/10.3892/ol.2020.11647
MLA
Zhao, T., Li, Y., Zhang, J., Zhang, B."PD‑L1 expression increased by IFN‑γ via JAK2‑STAT1 signaling and predicts a poor survival in colorectal cancer". Oncology Letters 20.2 (2020): 1127-1134.
Chicago
Zhao, T., Li, Y., Zhang, J., Zhang, B."PD‑L1 expression increased by IFN‑γ via JAK2‑STAT1 signaling and predicts a poor survival in colorectal cancer". Oncology Letters 20, no. 2 (2020): 1127-1134. https://doi.org/10.3892/ol.2020.11647
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao T, Li Y, Zhang J and Zhang B: PD‑L1 expression increased by IFN‑γ via JAK2‑STAT1 signaling and predicts a poor survival in colorectal cancer. Oncol Lett 20: 1127-1134, 2020.
APA
Zhao, T., Li, Y., Zhang, J., & Zhang, B. (2020). PD‑L1 expression increased by IFN‑γ via JAK2‑STAT1 signaling and predicts a poor survival in colorectal cancer. Oncology Letters, 20, 1127-1134. https://doi.org/10.3892/ol.2020.11647
MLA
Zhao, T., Li, Y., Zhang, J., Zhang, B."PD‑L1 expression increased by IFN‑γ via JAK2‑STAT1 signaling and predicts a poor survival in colorectal cancer". Oncology Letters 20.2 (2020): 1127-1134.
Chicago
Zhao, T., Li, Y., Zhang, J., Zhang, B."PD‑L1 expression increased by IFN‑γ via JAK2‑STAT1 signaling and predicts a poor survival in colorectal cancer". Oncology Letters 20, no. 2 (2020): 1127-1134. https://doi.org/10.3892/ol.2020.11647
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