Open Access

Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells

  • Authors:
    • Yan Huang
    • Ting Bao
    • Zhenzhen Li
    • Guiyi Ji
    • Li Zhang
  • View Affiliations

  • Published online on: May 20, 2020     https://doi.org/10.3892/ol.2020.11649
  • Pages: 1256-1262
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung cancer is the most prevalent type of cancer worldwide and is the leading cause of cancer‑associated cases of mortality in the USA and China. Non‑small cell lung cancer (NSCLC) accounts for 80‑85% of lung cancer cases. microRNAs (miRs) serve multiple roles in the pathogenesis of lung cancer. The current study investigated the lower level of miR‑200a in tumor tissues compared with healthy tissue. Overexpression of miR‑200a inhibited NSCLC cell proliferation and promoted apoptosis. miR‑200a was identified to target Rhophilin Rho GTPase binding protein 2 (RHPN2) and higher levels of RHPN2 were observed in tumor tissues compared with adjacent normal tissues. The current study proposes that miR‑200a exhibits a tumor suppressive role in NSCLC and suggests that miR‑200a could target RHPN2.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Huang, Y., Bao, T., Li, Z., Ji, G., & Zhang, L. (2020). Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells. Oncology Letters, 20, 1256-1262. https://doi.org/10.3892/ol.2020.11649
MLA
Huang, Y., Bao, T., Li, Z., Ji, G., Zhang, L."Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells". Oncology Letters 20.2 (2020): 1256-1262.
Chicago
Huang, Y., Bao, T., Li, Z., Ji, G., Zhang, L."Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells". Oncology Letters 20, no. 2 (2020): 1256-1262. https://doi.org/10.3892/ol.2020.11649