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Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells

  • Authors:
    • Yan Huang
    • Ting Bao
    • Zhenzhen Li
    • Guiyi Ji
    • Li Zhang
  • View Affiliations / Copyright

    Affiliations: Health Management Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China, Laboratory of Pathology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1256-1262
    |
    Published online on: May 20, 2020
       https://doi.org/10.3892/ol.2020.11649
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Abstract

Lung cancer is the most prevalent type of cancer worldwide and is the leading cause of cancer‑associated cases of mortality in the USA and China. Non‑small cell lung cancer (NSCLC) accounts for 80‑85% of lung cancer cases. microRNAs (miRs) serve multiple roles in the pathogenesis of lung cancer. The current study investigated the lower level of miR‑200a in tumor tissues compared with healthy tissue. Overexpression of miR‑200a inhibited NSCLC cell proliferation and promoted apoptosis. miR‑200a was identified to target Rhophilin Rho GTPase binding protein 2 (RHPN2) and higher levels of RHPN2 were observed in tumor tissues compared with adjacent normal tissues. The current study proposes that miR‑200a exhibits a tumor suppressive role in NSCLC and suggests that miR‑200a could target RHPN2.
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Copy and paste a formatted citation
Spandidos Publications style
Huang Y, Bao T, Li Z, Ji G and Zhang L: Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells. Oncol Lett 20: 1256-1262, 2020.
APA
Huang, Y., Bao, T., Li, Z., Ji, G., & Zhang, L. (2020). Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells. Oncology Letters, 20, 1256-1262. https://doi.org/10.3892/ol.2020.11649
MLA
Huang, Y., Bao, T., Li, Z., Ji, G., Zhang, L."Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells". Oncology Letters 20.2 (2020): 1256-1262.
Chicago
Huang, Y., Bao, T., Li, Z., Ji, G., Zhang, L."Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells". Oncology Letters 20, no. 2 (2020): 1256-1262. https://doi.org/10.3892/ol.2020.11649
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Y, Bao T, Li Z, Ji G and Zhang L: Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells. Oncol Lett 20: 1256-1262, 2020.
APA
Huang, Y., Bao, T., Li, Z., Ji, G., & Zhang, L. (2020). Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells. Oncology Letters, 20, 1256-1262. https://doi.org/10.3892/ol.2020.11649
MLA
Huang, Y., Bao, T., Li, Z., Ji, G., Zhang, L."Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells". Oncology Letters 20.2 (2020): 1256-1262.
Chicago
Huang, Y., Bao, T., Li, Z., Ji, G., Zhang, L."Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells". Oncology Letters 20, no. 2 (2020): 1256-1262. https://doi.org/10.3892/ol.2020.11649
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