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Long non‑coding RNA LINC00460 predicts poor survival and promotes cell viability in pancreatic cancer

  • Authors:
    • Junfeng Sun
    • Jianying Yang
    • Kui Lv
    • Jianguo Guan
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Anhui No. 2 Provincial People's Hospital, Hefei, Anhui 230041, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1369-1375
    |
    Published online on: May 20, 2020
       https://doi.org/10.3892/ol.2020.11652
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Abstract

Emerging evidence has demonstrated that long non‑coding RNAs (lncRNAs) possess great potential as vital biomarkers and powerful therapeutic targets in various diseases. In the present study, differentially expressed transcripts in pancreatic cancer (PC) were identified, and a competing endogenous RNA (ceRNA) network was constructed using The Cancer Genome Atlas database. An independent cohort consisting of 59 patients with PC was used to validate the clinical value of the identified lncRNA. Cell viability and colony formation assays were used to evaluate the biological functions of the lncRNA in PC cells. The present bioinformatic analysis revealed that LINC00460 was upregulated in PC samples with a prognostic significance. In the ceRNA network, it potentially targeted the microRNA‑503/cyclin D1 axis. The results of real‑time quantitative PCR confirmed that LINC00460 was significantly upregulated in cancer tissues and was associated with poor survival of patients with PC. The expression levels of LINC00460 were significantly associated with tumor size, but not with age, sex, differentiation, lymph node metastasis, vascular invasion and tumor stage. Through univariate and multivariate analysis, LINC00460 was characterized as an independent prognostic biomarker for PC. Further in vitro experiments demonstrated that suppressing LINC00460 using small interfering RNA inhibited viability and colony formation of PC cells. In summary, LINC00460 may be an independent prognostic biomarker for PC and may serve as an oncogenic lncRNA that promotes PC cell growth. Further in‑depth exploration is required to reveal the specific biological mechanism of LINC00460 in PC cells.
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1 

DeSantis CE, Miller KD, Goding Sauer A, Jemal A and Siegel RL: Cancer statistics for African Americans, 2019. CA Cancer J Clin. 69:211–233. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Chiorean EG and Coveler AL: Pancreatic cancer: Optimizing treatment options, new, and emerging targeted therapies. Drug Des Devel Ther. 9:3529–3545. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Peng WX, Koirala P and Mo YY: LncRNA-mediated regulation of cell signaling in cancer. Oncogene. 36:5661–5667. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Rupaimoole R and Slack FJ: MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 16:203–222. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Mansoori B, Mohammadi A, Shirjang S and Baradaran B: MicroRNAs in the diagnosis and treatment of cancer. Immunol Invest. 46:880–897. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Qi X, Zhang DH, Wu N, Xiao JH, Wang X and Ma W: ceRNA in cancer: Possible functions and clinical implications. J Med Genet. 52:710–718. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Kong YG, Cui M, Chen SM, Xu Y, Xu Y and Tao ZZ: LncRNA-LINC00460 facilitates nasopharyngeal carcinoma tumorigenesis through sponging miR-149-5p to up-regulate IL6. Gene. 639:77–84. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Li K, Sun D, Gou Q, Ke X, Gong Y, Zuo Y, Zhou JK, Guo C, Xia Z, Liu L, et al: Long non-coding RNA linc00460 promotes epithelial-mesenchymal transition and cell migration in lung cancer cells. Cancer Lett. 420:80–90. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Wang F, Liang S, Liu X, Han L, Wang J and Du Q: LINC00460 modulates KDM2A to promote cell proliferation and migration by targeting miR-342-3p in gastric cancer. OncoTargets Ther. 11:6383–6394. 2018. View Article : Google Scholar

10 

Liang Y, Wu Y, Chen X, Zhang S, Wang K, Guan X, Yang K, Li J and Bai Y: A novel long noncoding RNA linc00460 up-regulated by CBP/P300 promotes carcinogenesis in esophageal squamous cell carcinoma. Biosci Rep. 37:BSR201710192017. View Article : Google Scholar : PubMed/NCBI

11 

Cancer Genome Atlas Research Network. Electronic address, . andrew_aguirre@dfci.harvard.edu; Cancer Genome Atlas Research Network: Integrated genomic characterization of pancreatic ductal adenocarcinoma. Cancer Cell. 32:185–203.e13. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−ΔΔC(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Ai B, Kong X, Wang X, Zhang K, Yang X, Zhai J, Gao R, Qi Y, Wang J, Wang Z, et al: LINC01355 suppresses breast cancer growth through FOXO3-mediated transcriptional repression of CCND1. Cell Death Dis. 10:5022019. View Article : Google Scholar : PubMed/NCBI

16 

Qie S and Diehl JA: Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med (Berl). 94:1313–1326. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Dykes IM and Emanueli C: Transcriptional and post-transcriptional gene regulation by long non-coding RNA. Genomics Proteomics Bioinformatics. 15:177–186. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Quinn JJ and Chang HY: Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 17:47–62. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Han P and Chang CP: Long non-coding RNA and chromatin remodeling. RNA Biol. 12:1094–1098. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Schmitt AM and Chang HY: Long Noncoding RNAs in cancer pathways. Cancer Cell. 29:452–463. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Flynn RA and Chang HY: Long noncoding RNAs in cell-fate programming and reprogramming. Cell Stem Cell. 14:752–761. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Zhang Y, Liu X, Li Q and Zhang Y: lncRNA LINC00460 promoted colorectal cancer cells metastasis via miR-939-5p sponging. Cancer Manag Res. 11:1779–1789. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Feng L, Rao M, Zhou Y, Zhang Y and Zhu Y: Long noncoding RNA 00460 (LINC00460) promotes glioma progression by negatively regulating miR-320a. J Cell Biochem. 120:9556–9563. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Zhu Y, Yang L, Chong QY, Yan H, Zhang W, Qian W, Tan S, Wu Z, Lobie PE and Zhu T: Long noncoding RNA Linc00460 promotes breast cancer progression by regulating the miR-489-5p/FGF7/AKT axis. Cancer Manag Res. 11:5983–6001. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Zhao H, Wang Y and Ren X: Nicotine promotes the development of non-small cell lung cancer through activating LINC00460 and PI3K/Akt signaling. Biosci Rep. 39:BSR201824432019. View Article : Google Scholar : PubMed/NCBI

26 

Awan HM, Shah A, Rashid F and Shan G: Primate-specific Long Non-coding RNAs and MicroRNAs. Genomics Proteomics Bioinformatics. 15:187–195. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Huang R, Lin JY and Chi YJ: MiR-519d reduces the 5-fluorouracil resistance in colorectal cancer cells by down-regulating the expression of CCND1. Eur Rev Med Pharmacol Sci. 22:2869–2875. 2018.PubMed/NCBI

28 

Zhu Y, Wen X and Zhao P: MicroRNA-365 inhibits cell growth and promotes apoptosis in melanoma by targeting BCL2 and Cyclin D1 (CCND1). Med Sci Monit. 24:3679–3692. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun J, Yang J, Lv K and Guan J: Long non‑coding RNA LINC00460 predicts poor survival and promotes cell viability in pancreatic cancer. Oncol Lett 20: 1369-1375, 2020.
APA
Sun, J., Yang, J., Lv, K., & Guan, J. (2020). Long non‑coding RNA LINC00460 predicts poor survival and promotes cell viability in pancreatic cancer. Oncology Letters, 20, 1369-1375. https://doi.org/10.3892/ol.2020.11652
MLA
Sun, J., Yang, J., Lv, K., Guan, J."Long non‑coding RNA LINC00460 predicts poor survival and promotes cell viability in pancreatic cancer". Oncology Letters 20.2 (2020): 1369-1375.
Chicago
Sun, J., Yang, J., Lv, K., Guan, J."Long non‑coding RNA LINC00460 predicts poor survival and promotes cell viability in pancreatic cancer". Oncology Letters 20, no. 2 (2020): 1369-1375. https://doi.org/10.3892/ol.2020.11652
Copy and paste a formatted citation
x
Spandidos Publications style
Sun J, Yang J, Lv K and Guan J: Long non‑coding RNA LINC00460 predicts poor survival and promotes cell viability in pancreatic cancer. Oncol Lett 20: 1369-1375, 2020.
APA
Sun, J., Yang, J., Lv, K., & Guan, J. (2020). Long non‑coding RNA LINC00460 predicts poor survival and promotes cell viability in pancreatic cancer. Oncology Letters, 20, 1369-1375. https://doi.org/10.3892/ol.2020.11652
MLA
Sun, J., Yang, J., Lv, K., Guan, J."Long non‑coding RNA LINC00460 predicts poor survival and promotes cell viability in pancreatic cancer". Oncology Letters 20.2 (2020): 1369-1375.
Chicago
Sun, J., Yang, J., Lv, K., Guan, J."Long non‑coding RNA LINC00460 predicts poor survival and promotes cell viability in pancreatic cancer". Oncology Letters 20, no. 2 (2020): 1369-1375. https://doi.org/10.3892/ol.2020.11652
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