Open Access

Rab5 regulates the proliferation, migration and invasion of glioma cells via cyclin E

  • Authors:
    • Zhao Jian
    • Lianglong Zhang
    • Liang Jin
    • Weitu Lan
    • Wei Zhang
    • Guiyan Gao
  • View Affiliations

  • Published online on: May 21, 2020     https://doi.org/10.3892/ol.2020.11660
  • Pages: 1055-1062
  • Copyright: © Jian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioma is the most common and lethal type of primary brain tumor, with a high mortality and recurrence rate. Rab5, which serves as a classic ontogenetic gene, is highly expressed in various types of tumor, including lung cancer, hepatocellular carcinoma and ovarian cancer. However, the exact role and the underlying mechanism of Rab5 in glioma remain unknown. Herein, the role of Rab5 in the tumorigenesis and metastasis of glioma cells was investigated. The upregulation of Rab5 in glioma tissues and cells was observed. The expression of Rab5 was positively associated with proliferation, migration and invasion of glioma cells. Moreover, Rab5 was involved in the cell cycle of glioma cells via the regulation of cyclin E. Data presented in the present study suggest Rab5 as a potential novel diagnostic and prognosis marker of glioma.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Jian Z, Zhang L, Jin L, Lan W, Zhang W and Gao G: Rab5 regulates the proliferation, migration and invasion of glioma cells via cyclin E. Oncol Lett 20: 1055-1062, 2020
APA
Jian, Z., Zhang, L., Jin, L., Lan, W., Zhang, W., & Gao, G. (2020). Rab5 regulates the proliferation, migration and invasion of glioma cells via cyclin E. Oncology Letters, 20, 1055-1062. https://doi.org/10.3892/ol.2020.11660
MLA
Jian, Z., Zhang, L., Jin, L., Lan, W., Zhang, W., Gao, G."Rab5 regulates the proliferation, migration and invasion of glioma cells via cyclin E". Oncology Letters 20.2 (2020): 1055-1062.
Chicago
Jian, Z., Zhang, L., Jin, L., Lan, W., Zhang, W., Gao, G."Rab5 regulates the proliferation, migration and invasion of glioma cells via cyclin E". Oncology Letters 20, no. 2 (2020): 1055-1062. https://doi.org/10.3892/ol.2020.11660