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Elevated CELSR3 expression is associated with hepatocarcinogenesis and poor prognosis

  • Authors:
    • Xiwu Ouyang
    • Zhiming Wang
    • Lei Yao
    • Gewen Zhang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Ouyang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1083-1092
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    Published online on: May 22, 2020
       https://doi.org/10.3892/ol.2020.11671
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Abstract

Cadherin EGF LAG seven‑pass G-type receptor 3 (CELSR3) has been reported to exhibit a cancer-specific pattern. The present study aimed to investigate the clinical value and functional role of CELSR3 in hepatocellular carcinoma (HCC), and determine the underlying molecular mechanism in patients with HCC. CELSR3 expression in tumor and paracancerous HCC tissues was obtained from The Cancer Genome Atlas. Differential expression analysis was performed using the edgeR package. Pearson correlation analysis was used to analyze the correlation between methylation and mRNA levels of CELSR3. Pathways affected by aberrant CELSR3 expression were identified through Gene Set Enrichment Analysis. The results demonstrated that CELSR3 was highly expressed in the early stage of cancer and was present throughout the entire cancer process, which suggested that CELSR3 may serve a key role in the carcinogenesis of HCC. In addition, upregulation of CELSR3 was associated with its methylation level; high CELSR3 expression indicated a shorter overall survival time. Multiple candidate genes were screened by integrating differentially expressed (DE) mRNAs and target genes of DE microRNAs (miRs). Subsequent pathway enrichment analysis demonstrated that the upregulated genes were predominantly enriched in the ‘Neuroactive ligand‑receptor interaction’ and ‘Cell cycle’ pathways, whereas the downregulated genes were primarily enriched in ‘Cytokine‑cytokine receptor interaction’ and ‘Metabolic pathways’. CELSR3 and its connected nodes and edges were initially removed from the miRNA‑mRNA regulatory network in order to prevent bias and compared with the network containing CELSR3 alone. The frequently dysregulated miRNAs were identified as miR‑181 family members, and the results suggested that miR‑181 and the Wnt/β‑catenin signaling pathway influenced CELSR3 expression.
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1 

Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Nikšić M, Bonaventure A, Valkov M, Johnson CJ, Estève J, et al: Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): Analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 391:1023–1075. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Venook AP, Papandreou C, Furuse J and de Guevara LL: The incidence and epidemiology of hepatocellular carcinoma: A global and regional perspective. Oncologist. 15 (Suppl 4):S5–S13. 2010. View Article : Google Scholar

3 

Stepien M, Fedirko V, Duarte-Salles T, Ferrari P, Freisling H, Trepo E, Trichopoulou A, Bamia C, Weiderpass E, Olsen A, et al: Prospective association of liver function biomarkers with development of hepatobiliary cancers. Cancer Epidemiol. 40:179–187. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Bhangui P, Adam R, Vibert E, Azoulay D, Samuel D and Castaing D: 41 resection or transplantation for early hepatocellular carcinoma in a cirrhotic liver-size does matter. J Clin Exp Hepatol. 1:1512011. View Article : Google Scholar

5 

Simoneau E, Hassanain M, Madkhali A, Salman A, Nudo CG, Chaudhury P and Metrakos P: (18)F-Fluorodeoxyglucose positron-emission tomography could have a prognostic role in patients with advanced hepatocellular carcinoma. Curr Oncol. 21:e551–e556. 2014. View Article : Google Scholar : PubMed/NCBIPubMed/NCBI

6 

Trevisani F, Cantarini MC, Wands JR and Bernardi M: Recent advances in the natural history of hepatocellular carcinoma. Carcinogenesis. 29:1299–1305. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Zheng H, Zou AE, Saad MA, Wang XQ, Kwok JG, Korrapati A, Li P, Kisseleva T, Wang-Rodriguez J and Ongkeko WM: Alcohol-dysregulated microRNAs in hepatitis B virus-related hepatocellular carcinoma. PLoS One. 12:e01785472017. View Article : Google Scholar : PubMed/NCBI

8 

Wang XJ, Zhang DL, Xu ZG, Ma ML, Wang WB, Li LL, Han XL, Huo Y, Yu X and Sun JP: Understanding cadherin EGF LAG seven-pass G-type receptors. J Neurochem. 131:699–711. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Usui T, Shima Y, Shimada Y, Hirano S, Burgess RW, Schwarz TL, Takeichi M and Uemura T: Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell. 98:585–595. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Langenhan T, Aust G and Hamann J: Sticky signaling-adhesion class G protein-coupled receptors take the stage. Sci Signal. 6:re32013. View Article : Google Scholar : PubMed/NCBI

11 

Jeong P, Ha YS, Cho IC, Yun SJ, Yoo ES, Kim IY, Choi YH, Moon SK and Kim WJ: Three-gene signature predicts disease progression of non-muscle invasive bladder cancer. Oncol Lett. 2:679–684. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Anwar SL and Lehmann U: DNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma. World J Gastroenterol. 20:7894–7913. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Ricketts CJ, Morris MR, Gentle D, Brown M, Wake N, Woodward ER, Clarke N, Latif F and Maher ER: Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinoma. Epigenetics. 7:278–290. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Erkan M, Weis N, Pan Z, Schwager C, Samkharadze T, Jiang X, Wirkner U, Giese NA, Ansorge W, Debus J, et al: Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells. Mol Cancer. 9:882010. View Article : Google Scholar : PubMed/NCBI

15 

Gu X, Li H, Sha L, Mao Y, Shi C and Zhao W: CELSR3 mRNA expression is increased in hepatocellular carcinoma and indicates poor prognosis. PeerJ. 7:e78162019. View Article : Google Scholar : PubMed/NCBI

16 

Khor GH, Froemming GR, Zain RB, Abraham TM and Lin TK: Involvement of CELSR3 hypermethylation in primary oral squamous cell carcinoma. Asian Pac J Cancer Prev. 17:219–223. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Xie Z, Dang Y, Wu H, He R, Ma J, Peng Z, Rong M, Li Z, Yang J, Jiang Y, et al: Effect of CELSR3 on the cell cycle and apoptosis of hepatocellular carcinoma cells. J Cancer. 11:2830–2844. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Hayes CN and Chayama K: MicroRNAs as biomarkers for liver disease and hepatocellular carcinoma. Int J Mol Sci. 17:2802016.

19 

Tat TT, Maroney PA, Chamnongpol S, Coller J and Nilsen TW: Cotranslational microRNA mediated messenger RNA destabilization. Elife. 5:e128802016. View Article : Google Scholar : PubMed/NCBI

20 

Zhang X, Xu X, Ge G, Zang X, Shao M, Zou S, Zhang Y, Mao Z, Zhang J, Mao F, et al: miR498 inhibits the growth and metastasis of liver cancer by targeting ZEB2. Oncol Rep. 41:1638–1648. 2019.PubMed/NCBI

21 

Liu H: MicroRNAs in breast cancer initiation and progression. Cell Mol Life Sci. 69:3587–3599. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Chu R, Mo G, Duan Z, Huang M, Chang J, Li X and Liu P: miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression. Cell Commun Signal. 12:452014. View Article : Google Scholar : PubMed/NCBI

23 

Fang T, Lv H, Lv G, Li T, Wang C, Han Q, Yu L, Su B, Guo L, Huang S, et al: Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer. Nat Commun. 9:1912018. View Article : Google Scholar : PubMed/NCBI

24 

Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, Kovatich AJ, Benz CC, Levine DA, Lee AV, et al: An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics. Cell. 173:400–416.e11. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Lu TX and Rothenberg ME: MicroRNA. J Allergy Clin Immunol. 141:1202–1207. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Kertesz M, Iovino N, Unnerstall U, Gaul U and Segal E: The role of site accessibility in microRNA target recognition. Nat Genet. 39:1278–1284. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Rehmsmeier M, Steffen P, Hochsmann M and Giegerich R: Fast and effective prediction of microRNA/target duplexes. RNA. 10:1507–1517. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Chung TK, Lau TS, Cheung TH, Yim SF, Lo KW, Siu NS, Chan LK, Yu MY, Kwong J, Doran G, et al: Dysregulation of microRNA-204 mediates migration and invasion of endometrial cancer by regulating FOXC1. Int J Cancer. 130:1036–1045. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Xie C, Mao X, Huang J, Ding Y, Wu J, Dong S, Kong L, Gao G, Li CY and Wei L: KOBAS 2.0: A web server for annotation and identification of enriched pathways and diseases. Nucleic Acids Res. 39:W316–W322. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Lee JW, Son MH, Cho HW, Ma YE, Yoo KH, Sung KW and Koo HH: Clinical significance of MYCN amplification in patients with high-risk neuroblastoma. Pediatr Blood Cancer. 65:e272572018. View Article : Google Scholar : PubMed/NCBI

34 

Laisné M, Gupta N, Kirsh O, Pradhan S and Defossez PA: Mechanisms of DNA methyltransferase recruitment in mammals. Genes (Basel). 9:6172018. View Article : Google Scholar

35 

Roos L, van Dongen J, Bell CG, Burri A, Deloukas P, Boomsma DI, Spector TD and Bell J: Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs. Clin Epigenetics. 8:72016. View Article : Google Scholar : PubMed/NCBI

36 

Li H, Zhao X, Li C, Sheng C and Bai Z: Integrated analysis of lncRNA-associated ceRNA network reveals potential biomarkers for the prognosis of hepatitis B virus-related hepatocellular carcinoma. Cancer Manag Res. 11:877–897. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Zhao Y, Xue F, Sun J, Guo S, Zhang H, Qiu B, Geng J, Gu J, Zhou X, Wang W, et al: Genome-wide methylation profiling of the different stages of hepatitis B virus-related hepatocellular carcinoma development in plasma cell-free DNA reveals potential biomarkers for early detection and high-risk monitoring of hepatocellular carcinoma. Clin Epigenetics. 6:302014. View Article : Google Scholar : PubMed/NCBI

38 

Kazi JU and Rönnstrand L: FMS-like Tyrosine kinase 3/FLT3: From basic science to clinical implications. Physiol Rev. 99:1433–1466. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Lebron MB, Brennan L, Damoci CB, Prewett MC, O'Mahony M, Duignan IJ, Credille KM, DeLigio JT, Starodubtseva M, Amatulli M, et al: A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth. Cancer Biol Ther. 15:1208–1218. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Ji J, Yamashita T and Wang XW: Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. Cell Biosci. 1:42011. View Article : Google Scholar : PubMed/NCBI

41 

Lu Y, Wang L, Liu P, Yang P and You M: Gene-expression signature predicts postoperative recurrence in stage I non-small cell lung cancer patients. PLoS One. 7:e308802012. View Article : Google Scholar : PubMed/NCBI

42 

Zhu CQ, Ding K, Strumpf D, Weir BA, Meyerson M, Pennell N, Thomas RK, Naoki K, Ladd-Acosta C, Liu N, et al: Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer. J Clin Oncol. 28:4417–4424. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Subramanian J and Simon R: Gene expression-based prognostic signatures in lung cancer: Ready for clinical use? J Natl Cancer Inst. 102:464–474. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Feng J, Xu Y, Wang M, Ruan Y, So KF, Tissir F, Goffinet A and Zhou L: A role for atypical cadherin Celsr3 in hippocampal maturation and connectivity. J Neurosci. 32:13729–13743. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ouyang X, Wang Z, Yao L and Zhang G: Elevated CELSR3 expression is associated with hepatocarcinogenesis and poor prognosis. Oncol Lett 20: 1083-1092, 2020.
APA
Ouyang, X., Wang, Z., Yao, L., & Zhang, G. (2020). Elevated CELSR3 expression is associated with hepatocarcinogenesis and poor prognosis. Oncology Letters, 20, 1083-1092. https://doi.org/10.3892/ol.2020.11671
MLA
Ouyang, X., Wang, Z., Yao, L., Zhang, G."Elevated CELSR3 expression is associated with hepatocarcinogenesis and poor prognosis". Oncology Letters 20.2 (2020): 1083-1092.
Chicago
Ouyang, X., Wang, Z., Yao, L., Zhang, G."Elevated CELSR3 expression is associated with hepatocarcinogenesis and poor prognosis". Oncology Letters 20, no. 2 (2020): 1083-1092. https://doi.org/10.3892/ol.2020.11671
Copy and paste a formatted citation
x
Spandidos Publications style
Ouyang X, Wang Z, Yao L and Zhang G: Elevated CELSR3 expression is associated with hepatocarcinogenesis and poor prognosis. Oncol Lett 20: 1083-1092, 2020.
APA
Ouyang, X., Wang, Z., Yao, L., & Zhang, G. (2020). Elevated CELSR3 expression is associated with hepatocarcinogenesis and poor prognosis. Oncology Letters, 20, 1083-1092. https://doi.org/10.3892/ol.2020.11671
MLA
Ouyang, X., Wang, Z., Yao, L., Zhang, G."Elevated CELSR3 expression is associated with hepatocarcinogenesis and poor prognosis". Oncology Letters 20.2 (2020): 1083-1092.
Chicago
Ouyang, X., Wang, Z., Yao, L., Zhang, G."Elevated CELSR3 expression is associated with hepatocarcinogenesis and poor prognosis". Oncology Letters 20, no. 2 (2020): 1083-1092. https://doi.org/10.3892/ol.2020.11671
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