Open Access

Multitarget stool DNA test compared with fecal occult blood test for colorectal cancer screening

  • Authors:
    • Cuiping Yang
    • Wei Wu
    • Yanping Yang
    • Xiaojin Yang
    • Jing Sun
    • Weiyu Zhang
    • Kun Liu
    • Haifeng Ying
    • Songyao Jiang
    • Xiaojun Yu
    • Yiqing Shi
    • Yufen Zhou
    • Shiyan Zhu
    • Ying Xu
    • Yanfei Ding
    • Ling Xie
    • Boer  Cai
    • Xiaorong Xin
    • Ping Chen
    • Ren Zhao
    • Yunlin Wu
  • View Affiliations

  • Published online on: May 25, 2020     https://doi.org/10.3892/ol.2020.11674
  • Pages: 1193-1200
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Patient screening is important for early diagnosis of colorectal cancer (CRC). The present study aimed to compare the multitarget stool DNA (mt‑sDNA) test with the fecal occult blood test (FOBT) for CRC screening. A total of 151 individuals were screened using colonoscopy, mt‑sDNA and FOBT for the detection of CRC and adenoma. The results of the mt‑sDNA test and FOBT were compared with colonoscopy to examine their sensitivity and specificity. Subsequently, the sensitivity and specificity of the mt‑sDNA test were compared with those of FOBT in CRC and large adenoma. Stool samples were collected from patients with CRC (n=50) or large adenoma (n=51), as well as from normal controls (n=50). The mt‑sDNA test outperformed FOBT in detecting CRC with a sensitivity of 90.0% (45/50) vs. 42.0% (21/50), advanced adenoma with a sensitivity of 70.6% (36/51) vs. 19.6% (10/51), stage I‑III CRC with a sensitivity of 91.9% (34/37) vs. 29.7% (11/37), and stage IV CRC with a sensitivity of 84.6% (11/13) vs. 76.9% (10/13). In addition, the mt‑sDNA test exhibited a specificity of 94.0% (47/50) in detecting CRC, which was superior to FOBT with a specificity of 90.0% (45/50). Therefore, the mt‑sDNA test may have higher sensitivity and specificity compared with FOBT in diagnosing both CRC and advanced adenoma.

Related Articles

Journal Cover

August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Yang, C., Wu, W., Yang, Y., Yang, X., Sun, J., Zhang, W. ... Wu, Y. (2020). Multitarget stool DNA test compared with fecal occult blood test for colorectal cancer screening. Oncology Letters, 20, 1193-1200. https://doi.org/10.3892/ol.2020.11674
MLA
Yang, C., Wu, W., Yang, Y., Yang, X., Sun, J., Zhang, W., Liu, K., Ying, H., Jiang, S., Yu, X., Shi, Y., Zhou, Y., Zhu, S., Xu, Y., Ding, Y., Xie, L., Cai, B., Xin, X., Chen, P., Zhao, R., Wu, Y."Multitarget stool DNA test compared with fecal occult blood test for colorectal cancer screening". Oncology Letters 20.2 (2020): 1193-1200.
Chicago
Yang, C., Wu, W., Yang, Y., Yang, X., Sun, J., Zhang, W., Liu, K., Ying, H., Jiang, S., Yu, X., Shi, Y., Zhou, Y., Zhu, S., Xu, Y., Ding, Y., Xie, L., Cai, B., Xin, X., Chen, P., Zhao, R., Wu, Y."Multitarget stool DNA test compared with fecal occult blood test for colorectal cancer screening". Oncology Letters 20, no. 2 (2020): 1193-1200. https://doi.org/10.3892/ol.2020.11674