Open Access

Tumor suppressor role of miR‑876‑5p in gastric cancer

  • Authors:
    • Hongwei Zhao
    • Yuzhu Zheng
    • Jia You
    • Jingyuan Xiong
    • Shi Ying
    • Linshen Xie
    • Xuejiao Song
    • Yuqin Yao
    • Zhaohui Jin
    • Chaoxiong Zhang
  • View Affiliations

  • Published online on: May 28, 2020     https://doi.org/10.3892/ol.2020.11680
  • Pages: 1281-1287
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer (GC) is the second most common cancer cause of cancer‑related mortality worldwide. Recent studies have demonstrated the function of microRNAs (miRNAs) in the pathogenesis of GC. miR‑876‑5p demonstrated an antitumor role in hepatocellular carcinoma and lung cancer; however, the function of miR‑876‑5p has not yet been fully identified in GC. Thus, the present study aimed to investigate the role of miR‑876‑5p in GC. The results of the present study demonstrated low expression levels of miR‑876‑5p in GC tumor tissues. Furthermore, overexpression of miR‑876‑5p inhibited GC cell proliferation and promoted apoptosis, whilst miR‑876‑5p knockdown promoted GC cell proliferation and decreased cisplatin sensitivity of GC cells. Transforming growth factor β‑receptor 1 was demonstrated to be a potential target gene of miR‑876‑5p. Overall, the results of the present study suggest that miR‑876‑5p plays an antitumor role in GC.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zhao, H., Zheng, Y., You, J., Xiong, J., Ying, S., Xie, L. ... Zhang, C. (2020). Tumor suppressor role of miR‑876‑5p in gastric cancer. Oncology Letters, 20, 1281-1287. https://doi.org/10.3892/ol.2020.11680
MLA
Zhao, H., Zheng, Y., You, J., Xiong, J., Ying, S., Xie, L., Song, X., Yao, Y., Jin, Z., Zhang, C."Tumor suppressor role of miR‑876‑5p in gastric cancer". Oncology Letters 20.2 (2020): 1281-1287.
Chicago
Zhao, H., Zheng, Y., You, J., Xiong, J., Ying, S., Xie, L., Song, X., Yao, Y., Jin, Z., Zhang, C."Tumor suppressor role of miR‑876‑5p in gastric cancer". Oncology Letters 20, no. 2 (2020): 1281-1287. https://doi.org/10.3892/ol.2020.11680