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Article Open Access

Tumor suppressor role of miR‑876‑5p in gastric cancer

  • Authors:
    • Hongwei Zhao
    • Yuzhu Zheng
    • Jia You
    • Jingyuan Xiong
    • Shi Ying
    • Linshen Xie
    • Xuejiao Song
    • Yuqin Yao
    • Zhaohui Jin
    • Chaoxiong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, P.R. China, Oncology Department, The Third People's Hospital of Chengdu, Southwest Jiaotong University Affiliated Hospital, Chengdu, Sichuan 611756, P.R. China, Healthy Food Evaluation Center, West China School of Public Health, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1281-1287
    |
    Published online on: May 28, 2020
       https://doi.org/10.3892/ol.2020.11680
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Abstract

Gastric cancer (GC) is the second most common cancer cause of cancer‑related mortality worldwide. Recent studies have demonstrated the function of microRNAs (miRNAs) in the pathogenesis of GC. miR‑876‑5p demonstrated an antitumor role in hepatocellular carcinoma and lung cancer; however, the function of miR‑876‑5p has not yet been fully identified in GC. Thus, the present study aimed to investigate the role of miR‑876‑5p in GC. The results of the present study demonstrated low expression levels of miR‑876‑5p in GC tumor tissues. Furthermore, overexpression of miR‑876‑5p inhibited GC cell proliferation and promoted apoptosis, whilst miR‑876‑5p knockdown promoted GC cell proliferation and decreased cisplatin sensitivity of GC cells. Transforming growth factor β‑receptor 1 was demonstrated to be a potential target gene of miR‑876‑5p. Overall, the results of the present study suggest that miR‑876‑5p plays an antitumor role in GC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao H, Zheng Y, You J, Xiong J, Ying S, Xie L, Song X, Yao Y, Jin Z, Zhang C, Zhang C, et al: Tumor suppressor role of miR‑876‑5p in gastric cancer. Oncol Lett 20: 1281-1287, 2020.
APA
Zhao, H., Zheng, Y., You, J., Xiong, J., Ying, S., Xie, L. ... Zhang, C. (2020). Tumor suppressor role of miR‑876‑5p in gastric cancer. Oncology Letters, 20, 1281-1287. https://doi.org/10.3892/ol.2020.11680
MLA
Zhao, H., Zheng, Y., You, J., Xiong, J., Ying, S., Xie, L., Song, X., Yao, Y., Jin, Z., Zhang, C."Tumor suppressor role of miR‑876‑5p in gastric cancer". Oncology Letters 20.2 (2020): 1281-1287.
Chicago
Zhao, H., Zheng, Y., You, J., Xiong, J., Ying, S., Xie, L., Song, X., Yao, Y., Jin, Z., Zhang, C."Tumor suppressor role of miR‑876‑5p in gastric cancer". Oncology Letters 20, no. 2 (2020): 1281-1287. https://doi.org/10.3892/ol.2020.11680
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao H, Zheng Y, You J, Xiong J, Ying S, Xie L, Song X, Yao Y, Jin Z, Zhang C, Zhang C, et al: Tumor suppressor role of miR‑876‑5p in gastric cancer. Oncol Lett 20: 1281-1287, 2020.
APA
Zhao, H., Zheng, Y., You, J., Xiong, J., Ying, S., Xie, L. ... Zhang, C. (2020). Tumor suppressor role of miR‑876‑5p in gastric cancer. Oncology Letters, 20, 1281-1287. https://doi.org/10.3892/ol.2020.11680
MLA
Zhao, H., Zheng, Y., You, J., Xiong, J., Ying, S., Xie, L., Song, X., Yao, Y., Jin, Z., Zhang, C."Tumor suppressor role of miR‑876‑5p in gastric cancer". Oncology Letters 20.2 (2020): 1281-1287.
Chicago
Zhao, H., Zheng, Y., You, J., Xiong, J., Ying, S., Xie, L., Song, X., Yao, Y., Jin, Z., Zhang, C."Tumor suppressor role of miR‑876‑5p in gastric cancer". Oncology Letters 20, no. 2 (2020): 1281-1287. https://doi.org/10.3892/ol.2020.11680
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