Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

MicroRNA‑100 functions as a tumor suppressor in cervical cancer via downregulating the SATB1 expression and regulating AKT/mTOR signaling pathway and epithelial‑to‑mesenchymal transition

Corrigendum in: /10.3892/ol.2021.13002
  • Authors:
    • Cuiping Huang
    • Xiaobo Qin
    • Na Zhao
    • Huijing Jin
    • Shuangjun Zhang
    • Haiyan Yang
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Department of Obstetrics and Gynecology, Zhangqiu Maternity and Child Care Hospital, Jinan, Shandong 250200, P.R. China, Department of Imaging, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Ward Department, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Radiology, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Interventional Medicine, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1336-1344
    |
    Published online on: May 29, 2020
       https://doi.org/10.3892/ol.2020.11686
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cervical cancer (CC) is a common malignant tumor among women worldwide, remaining the fourth most frequent cause of cancer death in women. Currently, microRNA (miRNA) is a prevalent topic in tumor‑related research. The present study focused on the mechanisms of miR‑100 in CC progression. qRT‑PCR analysis revealed that the miR‑100 expression was notably decreased in CC tissues. In addition, miR‑100 downregulation was confirmed to be significantly related to the malignant clinicopathologic features of CC patients. Furthermore, miR‑100 overexpression was also verified to significantly repress CC cell proliferation, migration and invasion abilities through modulating the AKT/mTOR signaling pathway and epithelial‑to‑mesenchymal transition. Bioinformatics analysis and luciferase reporter assay identified that special AT‑rich sequence‑binding protein 1 was a functional target for miR‑100 in CC cells. Moreover, miR‑100 overexpression was found to markedly repress the CC tumor growth in vivo. In conclusion, the above results revealed that miR‑100 functioned as a cancer suppressor in CC progression and may provide insights into the novel therapeutic target for CC treatment.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Carr KR, Ioffe YJ, Filippova M, Duerksen-Hughes P and Chan PJ: Combined ultrasound-curcumin treatment of human cervical cancer cells. Eur J Obstet Gynecol Reprod Biol. 193:96–101. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Yu Q, Yang X, Duan W, Li C, Luo Y and Lu S: miRNA-346 promotes proliferation, migration and invasion in liver cancer. Oncol Lett. 14:3255–3260. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Puik JR, Meijer LL, Le Large TY, Prado MM, Frampton AE, Kazemier G and Giovannetti E: miRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma. Pharmacogenomics. 18:1343–1358. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Fang H, Xie J, Zhang M, Zhao Z, Wan Y and Yao Y: miRNA-21 promotes proliferation and invasion of triple-negative breast cancer cells through targeting PTEN. Am J Transl Res. 9:953–961. 2017.PubMed/NCBI

6 

Xiao R, Li C and Chai B: miRNA-144 suppresses proliferation and migration of colorectal cancer cells through GSPT1. Biomed Pharmacother. 74:138–144. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Yang L, Liang H, Wang Y, Gao S, Yin K, Liu Z, Zheng X, Lv Y, Wang L, Zhang CY, et al: MiRNA-203 suppresses tumor cell proliferation, migration and invasion by targeting Slug in gastric cancer. Protein Cell. 7:383–387. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Deng B, Zhang S, Zhang Y, Miao Y, Meng X and Guo K: Knockdown of Tripartite Motif Containing 28 suppresses the migration, invasion and epithelial-mesenchymal transition in ovarian carcinoma cells through downregulation of Wnt/β-catenin signaling pathway. Neoplasma. 64:893–900. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Wu HY and Cai XP: miR-338-3p suppresses epithelial-mesenchymal transition and metastasis in human nonsmall cell lung cancer. Indian J Cancer. 52 (Suppl 3):E168–E171. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Chen H, Jia W and Li J: ECM1 promotes migration and invasion of hepatocellular carcinoma by inducing epithelial-mesenchymal transition. World J Surg Oncol. 14:1952016. View Article : Google Scholar : PubMed/NCBI

11 

Colditz J, Rupf B, Maiwald C and Baniahmad A: Androgens induce a distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells. Mol Cell Biochem. 421:139–147. 2016. View Article : Google Scholar : PubMed/NCBI

12 

He H, Dai J, Xu Z, He W, Wang X, Zhu Y and Wang H: Fbxw7 regulates renal cell carcinoma migration and invasion via suppression of the epithelial-mesenchymal transition. Oncol Lett. 15:3694–3702. 2018.PubMed/NCBI

13 

Chen X, Liao Y, Yu Y, Zhu P, Li J, Qin L, Liao W and Huang Z: Elevation of MAP17 enhances the malignant behavior of cells via the Akt/mTOR pathway in hepatocellular carcinoma. Oncotarget. 8:92589–92603. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Xue L, Wang Y, Yue S and Zhang J: Low MiR-149 expression is associated with unfavorable prognosis and enhanced Akt/mTOR signaling in glioma. Int J Clin Exp Pathol. 8:11178–11184. 2015.PubMed/NCBI

15 

Cai S, Han HJ and Kohwi-Shigematsu T: Tissue-specific nuclear architecture and gene expression regulated by SATB1. Nat Genet. 34:42–51. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Qi H, Fu X, Li Y, Pang X, Chen S, Zhu X, Li F and Tan W: SATB1 promotes epithelial-mesenchymal transition and metastasis in prostate cancer. Oncol Lett. 13:2577–2582. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Li YC, Bu LL, Mao L, Ma SR, Liu JF, Yu GT, Deng WW, Zhang WF and Sun ZJ: SATB1 promotes tumor metastasis and invasiveness in oral squamous cell carcinoma. Oral Dis. 23:247–254. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Pan Z, Jing W, He K, Zhang L and Long X: SATB1 is correlated with progression and metastasis of breast cancers: A meta-analysis. Cell Physiol Biochem. 38:1975–1983. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Hu XT, Chen W, Zhang FB, Shi QL, Hu JB, Geng SM and He C: Depletion of the proteasome subunit PSMA7 inhibits colorectal cancer cell tumorigenicity and migration. Oncol Rep. 22:1247–1252. 2009.PubMed/NCBI

20 

Hu XT, Chen W, Wang D, Shi QL, Zhang FB, Liao YQ, Jin M and He C: The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer. Oncol Rep. 19:441–446. 2008.PubMed/NCBI

21 

Kessler TA: Cervical cancer: Prevention and early detection. Semin Oncol Nurs. 33:172–183. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Cordeiro MN, De Lima RC, Paolini F, Melo AR, Campos AP, Venuti A and De Freitas AC: Current research into novel therapeutic vaccines against cervical cancer. Expert Rev Anticancer Ther. 18:365–376. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Zhang Y, Zhang D, Wang F, Xu D, Guo Y and Cui W: Serum miRNAs panel (miR-16-2*, miR-195, miR-2861, miR-497) as novel non-invasive biomarkers for detection of cervical cancer. Sci Rep. 5:179422015. View Article : Google Scholar : PubMed/NCBI

24 

Chen XF and Liu Y: MicroRNA-744 inhibited cervical cancer growth and progression through apoptosis induction by regulating Bcl-2. Biomed Pharmacother. 81:379–387. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Chen AH, Qin YE, Tang WF, Tao J, Song HM and Zuo M: MiR-34a and miR-206 act as novel prognostic and therapy biomarkers in cervical cancer. Cancer Cell Int. 17:632017. View Article : Google Scholar : PubMed/NCBI

26 

Liu Y, Zhu ST, Wang X, Deng J, Li WH, Zhang P and Liu BS: MiR-100 inhibits osteosarcoma cell proliferation, migration, and invasion and enhances chemosensitivity by targeting IGFIR. Technol Cancer Res Treat. 15:NP40–NP48. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Luan Y, Zhang S, Zuo L and Zhou L: Overexpression of miR-100 inhibits cell proliferation, migration, and chemosensitivity in human glioblastoma through FGFR3. Onco Targets Ther. 8:3391–3400. 2015.PubMed/NCBI

28 

Qureshi A, Fahim A, Kazi N, Farsi Kazi SA and Nadeem F: Expression of miR-100 as a novel ancillary non-invasive biomarker for early detection of bladder carcinoma. J Pak Med Assoc. 68:759–763. 2018.PubMed/NCBI

29 

Xiao T, Fu L and Jie Z: SATB1 overexpression correlates with gastrointestinal neoplasms invasion and metastasis: A meta-analysis for Chinese population. Oncotarget. 8:48282–48290. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Huang B, Xiong F, Wang S, Lang X, Wang X and Zhou H: Effect of SATB1 silencing on the proliferation, invasion and apoptosis of TE-1 esophageal cancer cells. Oncol Lett. 13:2915–2920. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang C, Qin X, Zhao N, Jin H, Zhang S and Yang H: MicroRNA‑100 functions as a tumor suppressor in cervical cancer via downregulating the SATB1 expression and regulating AKT/mTOR signaling pathway and epithelial‑to‑mesenchymal transition Corrigendum in /10.3892/ol.2021.13002. Oncol Lett 20: 1336-1344, 2020.
APA
Huang, C., Qin, X., Zhao, N., Jin, H., Zhang, S., & Yang, H. (2020). MicroRNA‑100 functions as a tumor suppressor in cervical cancer via downregulating the SATB1 expression and regulating AKT/mTOR signaling pathway and epithelial‑to‑mesenchymal transition Corrigendum in /10.3892/ol.2021.13002. Oncology Letters, 20, 1336-1344. https://doi.org/10.3892/ol.2020.11686
MLA
Huang, C., Qin, X., Zhao, N., Jin, H., Zhang, S., Yang, H."MicroRNA‑100 functions as a tumor suppressor in cervical cancer via downregulating the SATB1 expression and regulating AKT/mTOR signaling pathway and epithelial‑to‑mesenchymal transition Corrigendum in /10.3892/ol.2021.13002". Oncology Letters 20.2 (2020): 1336-1344.
Chicago
Huang, C., Qin, X., Zhao, N., Jin, H., Zhang, S., Yang, H."MicroRNA‑100 functions as a tumor suppressor in cervical cancer via downregulating the SATB1 expression and regulating AKT/mTOR signaling pathway and epithelial‑to‑mesenchymal transition Corrigendum in /10.3892/ol.2021.13002". Oncology Letters 20, no. 2 (2020): 1336-1344. https://doi.org/10.3892/ol.2020.11686
Copy and paste a formatted citation
x
Spandidos Publications style
Huang C, Qin X, Zhao N, Jin H, Zhang S and Yang H: MicroRNA‑100 functions as a tumor suppressor in cervical cancer via downregulating the SATB1 expression and regulating AKT/mTOR signaling pathway and epithelial‑to‑mesenchymal transition Corrigendum in /10.3892/ol.2021.13002. Oncol Lett 20: 1336-1344, 2020.
APA
Huang, C., Qin, X., Zhao, N., Jin, H., Zhang, S., & Yang, H. (2020). MicroRNA‑100 functions as a tumor suppressor in cervical cancer via downregulating the SATB1 expression and regulating AKT/mTOR signaling pathway and epithelial‑to‑mesenchymal transition Corrigendum in /10.3892/ol.2021.13002. Oncology Letters, 20, 1336-1344. https://doi.org/10.3892/ol.2020.11686
MLA
Huang, C., Qin, X., Zhao, N., Jin, H., Zhang, S., Yang, H."MicroRNA‑100 functions as a tumor suppressor in cervical cancer via downregulating the SATB1 expression and regulating AKT/mTOR signaling pathway and epithelial‑to‑mesenchymal transition Corrigendum in /10.3892/ol.2021.13002". Oncology Letters 20.2 (2020): 1336-1344.
Chicago
Huang, C., Qin, X., Zhao, N., Jin, H., Zhang, S., Yang, H."MicroRNA‑100 functions as a tumor suppressor in cervical cancer via downregulating the SATB1 expression and regulating AKT/mTOR signaling pathway and epithelial‑to‑mesenchymal transition Corrigendum in /10.3892/ol.2021.13002". Oncology Letters 20, no. 2 (2020): 1336-1344. https://doi.org/10.3892/ol.2020.11686
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team