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Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression

  • Authors:
    • Aggelis Stavropoulos
    • Michail Varras
    • Thivi Vasilakaki
    • Viktoria‑Konstantina Varra
    • Fani‑Niki Varra
    • Aikaterini Tsavari
    • Aphrodite Nonni
    • Nikolaos Kavantzas
    • Andreas C. Lazaris
  • View Affiliations / Copyright

    Affiliations: Forth Obstetrics and Gynecology Department, ‘Elena Venizelou’ General Hospital, Athens 11521, Greece, Fifth Obstetrics and Gynecology Department, ‘Elena Venizelou’ General Hospital, Athens 11521, Greece, Department of Pathology, ‘Tzaneio’ General Hospital, Piraeus 18536, Greece, Department of Pharmacy, University of Patras, Patra 26504, Greece, Department of Pharmacy, Frederick University, Nicosia 1036, Cyprus, First Pathology Department, Medical School, National Kapodistrian University, Athens 11527, Greece
    Copyright: © Stavropoulos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1033-1054
    |
    Published online on: May 30, 2020
       https://doi.org/10.3892/ol.2020.11690
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Abstract

Endometrial carcinoma is one of the most common types of gynecological cancer. A total of 99 cases of primary endometrial carcinoma were investigated for survivin expression by immunohistochemistry. Furthermore, the association between concomitant survivin, PTEN and p53 expression, and clinicopathological parameters was examined. Immunopositivity for survivin was identified in 88% of cases. Concomitant survivin, PTEN and p53 expression (staining scores and intensity) was observed in 60% of endometrial adenocarcinomas. A significant association was identified between the sum of staining intensity and scores of survivin immunopositive cells, and patient age (P=0.028), histological grade (P<0.001), clinical stage (P=0.018) and fallopian tube and/or ovarian invasion (P=0.039). A negative tendency for correlation was observed between surivin and PTEN immunostaining scores (P=0.062; ρ=‑0.238). Specimens with high scores of survivin expression tended to show decreased scores of PTEN immunostaining, and vice versa. However, in circumstances with an increased co‑expression of survivin and PTEN, a statistically significant association with histological types was observed (P=0.020). A statistically significant positive correlation was identified between survivin and p53 sum co‑expression (P=0.008; ρ=0.300). Furthermore, a significant association was identified between survivin and p53 concomitant sum expression and age of patients (P=0.001), histological type (P=0.020), clinical stage (P=0.037), histological differentiation (P=0.001) and presence of fallopian tube and/or ovarian invasion (P=0.026). The present findings suggested that survivin may be an indicator of unfavorable outcome in older patients with endometrial carcinoma, in specific circumstances that are dependent on different concomitant genetic alterations and different combinations of molecular signaling pathways. Increased expression levels of survivin and PTEN may serve a role in the development of more aggressive endometrial carcinoma during their interaction. In addition, protein expression levels of survivin and p53 are positively correlated and may share a common molecular pathway to promote endometrial carcinogenesis. These findings provided evidence that survivin and p53 combined may be useful markers for the prediction of tumor behavior and prognosis.
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View References

1 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Sadlecki P, Bodnar M, Grabiec M, Marszalek A, Walentowicz P, Sokup A, Zegarska J and Walentowicz-Sadlecka M: The role of Hypoxia-inducible factor 1α, glucose transporter-1 (GLUT-1) and carbon anhydrase IX in endometrial cancer patients. Biomed Res Int. 2014:6168502014. View Article : Google Scholar : PubMed/NCBI

3 

Daniilidou K, Frangou-Plemenou M, Grammatikakis J, Grigoriou O, Vitoratos N and Kondi-Pafiti A: Prognostic significance and diagnostic value of PTEN and p53 expression in endometrial carcinoma. A retrospective clinicopathological and immunohistochemical study. J BUON. 18:195–201. 2013.PubMed/NCBI

4 

Talhouk A and McAlpine JN: New classification of endometrial cancers: The development and potential applications of genomic-based classification in research and clinical care. Gynecol Oncol Res Pract. 3:142016. View Article : Google Scholar : PubMed/NCBI

5 

Taoussi N, Alghamdi A, Futyma K and Rechberger T: Biological markers with potential clinical value in endometrial cancer-review of the literature. Ginekol Pol. 88:331–336. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Mancebo G, Sole-Sedeno JM, Pino O, Miralpeix E, Mojal S, Garrigos L, Lloveras B, Navarro P, Gibert J, Lorenzo M, et al: Prognostic impact of CD133 expression in endometrial cancer patients. Sci Rep. 7:76872017. View Article : Google Scholar : PubMed/NCBI

7 

Zhang HM, Fan TT, Li W and Li XX: Expressions and significances of TTF-1 and PTEN in early endometrial cancer. Eur Rev Med Pharmacol. 21 (3 Suppl):S20–S26. 2017.

8 

Hashmi AA, Hussain ZF, Qadri A, Irfan M, Ramzan S, Faridi N, Khan A and Edhi MM: Androgen receptor expression in endometrial carcinoma and its correlation with clinicopathologic features. BMC Res Notes. 11:2892018. View Article : Google Scholar : PubMed/NCBI

9 

Bakkum-Gamez JN, Gonzalez-Bosquet J, Laack NN, Mariani A and Dowdy SC: Current issues in the management of endometrial cancer. Mayo Clin Proc. 83:97–112. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Ambrosini G, Adida C and Altieri DC: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 3:917–921. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Rudin CM and Thompson CB: Apoptosis and disease: Regulation and clinical relevance of programmed cell death. Annu Rev Med. 48:267–281. 1997. View Article : Google Scholar : PubMed/NCBI

12 

LaCasse EC, Baird S, Korneluk RG and MacKenzie AE: The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncology. 17:3247–3259. 1998.

13 

Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T and Reed JC: IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 58:5315–5320. 1998.PubMed/NCBI

14 

Altieri DC: Survivin, cancer networks and path-directed drug discovery. Nat Rev Cancer. 8:61–70. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Cohen C, Lohmann CM, Cotsonis G, Lawson D and Santoianni R: Survivin expression in ovarian carcinoma: Correlation with apoptotic markers and prognosis. Mod Pathol. 16:574–583. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Takai N, Miyazaki T, Nishida M, Nasu K and Miyakawa I: Survivin expression correlates with clinical stage, histological grade, invasive behavior and survival rate in endometrial carcinoma. Cancer Lett. 184:105–116. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Tran J, Master Z, Yu JL, Rak J, Dumont DJ and Kerbel RS: A role for survivin in chemoresistance of endothelial cells mediated by VEGF. Proc Natl Acad Sci USA. 99:4349–4354. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Altieri DC: Survivin, versatile modulation of cell division and apoptosis in cancer. Oncogene. 22:8581–8589. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Altieri DC: Survivin and apoptosis control. Adv Cancer Res. 88:31–52. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Mita AC, Mita MM, Nawrocki ST and Giles FJ: Survivin: Key regular of mitosis and apoptosis and novel target for cancer therapeutics. Clin Cancer Res. 14:5000–5005. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Li F, Ambrosini G, Chu EY, Plescia J, Tognin S, Marchisio PC and Altieri DC: Control of apoptosis and mitotic spindle checkpoing by survivin. Nature. 396:580–584. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Mahotka C, Wenzel M, Springer E, Gabbert HE and Gerharz CD: Survivin-deltaEx3 and survivin-2B: Two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. Cancer Res. 59:6097–6102. 1999.PubMed/NCBI

23 

Zhang M, Yang J and Li F: Transcriptional and post-transcriptional controls of survivin in cancer cells: Novel approaches for cancer treatment. J Exp Clin Cancer Res. 25:391–402. 2006.PubMed/NCBI

24 

Dohi T, Beltrami E, Wall NR, Plescia J and Alteiri DC: Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis. J Clin Invest. 114:1117–1127. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Sui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K and Tokuda M: Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. Int J Oncol. 21:315–120. 2002.PubMed/NCBI

26 

Guha M, Plescia J, Leav I, Li J, Languino LR and Altieri DC: Endogenous tumor suppression mediated by PTEN involves survivin gene silencing. Cancer Res. 69:4954–4958. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Kim S, Kang J, Qiao J, Thomas RP, Evers BM and Chung DH: Phosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas. J Padiatr Surg. 39:516–521. 2004. View Article : Google Scholar

28 

Sui L, Dong, Watanabe Y, Yamaguchi F, Sugimoto K and Tokuda M: Alteration and clinical relevance of PTEN expression and its correlation with survivin expression in epithelial ovarian tumors. Oncol Rep. 15:773–778. 2006.PubMed/NCBI

29 

Grossman D, Kim PJ, Blanc-Brude OP, Brash DE, Tognin S, Marchisio PC and Altieri DC: Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53. J Clin Invest. 108:991–999. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Hoffman WH, Biade S, Zilfou JT, Chen J and Murphy M: Trascriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem. 277:3247–3257. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Mirza A, McGuirk M, Hockenberry TN, Wu Q, Ashar H, Black S, Wen SF, Wang L, Kirschmeier P, Bishop WR, et al: Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway. Oncogene. 21:2613–2622. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Kannangai R, Wang J, Liu QZ, Sahin F and Torbenson M: Survivin overexpression in hepatocellular carcinoma is associated with p53 dysregulation. Int J Gastrointest Cancer. 35:53–60. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Felisiak-Golabek A, Rembiszewska A, Rzepecka IK Szafron L, Madry R, Murawska M, Napiorkowski T, Sobiczewski P, Osuch B and Kupryjanczyk J; PolishOvarian Cancer Study Group (POCSG), : Nuclear survivin expression is a positive prognostic factor in taxane-platinum-treated ovarian cancer patients. J Ovarian Res. 4:202011. View Article : Google Scholar : PubMed/NCBI

34 

Gąsowska-Bodnar A, Bodnar L, Dąbek A, Cichowicz M, Jerzak M, Cierniak S, Kozłowski W and Baranowski W: Survivin expression as a prognostic factor in patients with epithelial ovarian cancer or primary peritoneal cancer treated with neoadjuvant chemotherapy. Int J Gynecol Cancer. 24:687–696. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Gonzalez S, Aubert S, Kerdraon O, Haddad O, Fantoni JC, Bisere J and Lorey X: Prognostic value of combined p53 and survivin in pT1G3 urothelial carcinoma of the bladder. Am J Clin Pathol. 129:232–237. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Pallares J, Martínez-Guitarte JL, Dolcet X, Llobet D, Rue M, Palacios J, Prat J and Matias-Guiu X: Survivin expression in endometrial carcinoma: A tissue microarray study with correlation with PTEN and STAT-3. Int J Gynecol Pathol. 24:247–253. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Erkanli S, Kayaselcuk F, Kuscu E, Bagis T, Bolat F, Haberal A and Demirhan B: Expression of survivin, PTEN and p27 in normal, hyperplastic, and carcinomatous endometrium. Int J Gynecol Cancer. 16:1412–1418. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Lambropoulou M, Papadopoulos N, Tripsianis G, Alexiadis G, Pagonopoulou O, Kiziridou A, Liberis V, Kakolyris S and Chatzaki E: Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): Prognostic value and survival of endometrial cancer patients. J Cancer Res Clin Oncol. 136:427–435. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Yilmaz E, Koyuncuoglu M, Görken IB, Okyay E, Saatli B, Ulukus EC and Saygili U: Expression of matrix metalloproteinase-2 and survivin in endometrioid and nonendometrioid endometrial cancers and clinicopathologic significance. J Gynecol Oncol. 22:89–96. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Brunner A, Riss P, Heinze G and Brustmann H: pHH3 and survivin are co-expressed in high-risk endometrial cancer and are prognostic relevant. Br J Cancer. 107:84–90. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Erkanli S, Bolat F, Kayaselcuk F, Demirhan B and Kuscu E: COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma. Gynecol Oncol. 104:320–325. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Aksoy RT, Turan AT, Boran N, Tokmak A, Isikdogan BZ, Tulunay HG and Dogan M: Lack of relation of survivin gene expression with survival and surgical prognostic factors in endometrial carcinoma patients. Asian Pac J Cancer Prev. 15:6905–6910. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Stavropoulos A, Varras M, Vasilakaki T, Varra VK, Tsavari A, Varra FN, Nonni A, Kavantzas N and Lazaris AC: Expression of p53 and PTEN in human primary endometrial carcinomas: Clinicopathological and immunohistochemical analysis and study of their concomitant expression. Oncol Lett. 17:4575–4589. 2019.PubMed/NCBI

44 

Lehner R, Enomoto T, McGregor JA, Shroyer L, Haugen BR, Pugazhenthi U and Shroyer KR: Correlation of survivin mRNA detection with histologic diagnosis in normal endometrium and endometrial carcinoma. Acta Obstet Gynecol Scand. 81:162–167. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Chuwa AH, Sone K, Oda K, Ikeda Y, Fukuda T, Wada-Hiraike O, Inaba K, Makii C, Takeuchi M, Oki S, et al: Significance of survivin as a prognostic factor and a therapeutic target in endometrial cancer. Gynecol Oncol. 141:564–569. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Saitoh Y, Yaginuma Y and Ishikawa M: Analysis of Bcl-2, Bax and survivin genes in uterine cancer. Int J Oncol. 15:137–141. 1999.PubMed/NCBI

47 

Konno R, Yamakawa H, Utsunomiya H, Ito K, Sato S and Yajima A: Expression of survivin and Bcl-2 in normal human endometrium. Mol Hum Reprod. 6:529–534. 2000. View Article : Google Scholar : PubMed/NCBI

48 

Ai Z, Yin L, Zhou X, Zhu Y, Zhu D, Yu Y and Feng Y: Inhibition of survivin reduces cell proliferation and induces apoptosis in human endometrial cancer. Cancer. 107:746–756. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Catasus L, Gallardo A, Cuatrecasas M and Prat J: Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis. Mod Pathol. 22:522–529. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Nout RA, Bosse T, Creutzberg CL, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, van Eijk R, Ter Haar NT and Smit VT: Improved risk assessment of endometrial cancer by combined analysis of MSI, PI3K-AKT, Wnt/β-caterin and P53 pathway activation. Gynecol Oncol. 126:466–473. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Uegaki K, Kanamori Y, Kigawa J, Kawaguchi W, Kaneko R, Naniwa J, Takahashi M, Shimada M, Oishi T, Itamochi H and Terakawa N: PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma. Oncol Rep. 14:389–392. 2005.PubMed/NCBI

52 

Deveraux QL and Reed JC: IAP family proteins-suppressors of apoptosis. Genes Dev. 13:239–252. 1999. View Article : Google Scholar : PubMed/NCBI

53 

Sanhueza C, Wehinger S, Castillo Bennett J, Valenzuela M, Owen GI and Quest AF: The twisted survivin connection to angiogenesis. Mol Cancer. 14:1982015. View Article : Google Scholar : PubMed/NCBI

54 

Yan YL and Li XM: The IAP family: Endogenous caspase inhibitors with multiple biological activities. Cell Res. 10:169–177. 2000. View Article : Google Scholar : PubMed/NCBI

55 

Mehrotra S, Languino LR, Raskett CM, Mercurio AM, Dohi T and Altieri DC: IAP regulation of metastasis. Cancer Cell. 17:53–64. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Cai X, Ma S, Gu M, Zu C, Qu W and Zheng X: Survivin regulates the expression of VEGF-C in lymphatic metastasis of breast cancer. Diagn Pathol. 7:522012. View Article : Google Scholar : PubMed/NCBI

57 

Zhang J, Zhu Z, Sun Z, Sun X, Wang Z and Xu H: Survivin gene expression increases gastric cancer cell hymphatic metastasis by upregulating vascular endothelial growth factor-C expression levels. Mol Med Red. 9:600–606. 2014. View Article : Google Scholar

58 

Selemtjev S, Savin S, Paunovic I, Tatic S and Cvejic D: Concomitant high expression of survivin and vascular endothelial growth factor-C is strong associated with metastatic status of lymph nodes in papillary thyroid carcinoma. J Cancer Res Ther. 14 (Suppl):S114–S119. 2018. View Article : Google Scholar : PubMed/NCBI

59 

Nakano J, Huang CL, Liu D, Ueno M, Sumitomo S and Yokomise H: Survivin gene expression is negatively regulated by the p53 tumor suppressor gene in non-small cell lung cancer. Int J Oncol. 27:1215–1221. 2005.PubMed/NCBI

60 

Lyu H, Huang J, He Z and Liu B: Epigenetic mechanist of survivin dysregulation in human cancer. Sci China Life Sci. 61:808–814. 2018. View Article : Google Scholar : PubMed/NCBI

61 

Chen X, Duan N, Zhang C and Zhang W: Survivin and tumorigenesis: Molecular mechanisms and therapeutic strategies. J Cancer. 7:314–323. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Pei SG, Wang JX, Wang XL, Zhang QJ and Zhang H: Correlation of survivin, p53 and Ki-67 in laryngeal cancer Hep-2 cell proliferation and invasion. Asian Pac J Trop Med. 8:636–642. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Estève PO, Chin HG and Pradhan S: Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells. J Biol Chem. 282:2615–2625. 2007. View Article : Google Scholar : PubMed/NCBI

64 

Smallwood A, Estève PO, Pradhan S and Carey M: Functional cooperation between HP1 and DNMT1 mediates gene silencing. Genes Dev. 21:1169–1178. 2007. View Article : Google Scholar : PubMed/NCBI

65 

Nabilsi NH, Broaddus RR and Loose DS: DNA methylation inhibits p53-mediated survivin repression. Oncogene. 28:2046–2050. 2009. View Article : Google Scholar : PubMed/NCBI

66 

Wang Z, Fukuda S and Pelus LM: Survivin regulates the p53 tumor suppressor gene family. Oncogene. 23:8146–8153. 2004. View Article : Google Scholar : PubMed/NCBI

67 

Guha M and Altieri DC: Survivin as a global target of intrinsic tumor suppression networks. Cell Cycle. 8:2708–2710. 2009. View Article : Google Scholar : PubMed/NCBI

68 

Calnan DR and Brunet A: The FoxO code. Oncogene. 27:2276–2288. 2008. View Article : Google Scholar : PubMed/NCBI

69 

Accili D and Arden KC: FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell. 117:421–426. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Stavropoulos A, Varras M, Vasilakaki T, Varra VK, Varra FN, Tsavari A, Nonni A, Kavantzas N and Lazaris AC: Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression. Oncol Lett 20: 1033-1054, 2020.
APA
Stavropoulos, A., Varras, M., Vasilakaki, T., Varra, V., Varra, F., Tsavari, A. ... Lazaris, A.C. (2020). Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression. Oncology Letters, 20, 1033-1054. https://doi.org/10.3892/ol.2020.11690
MLA
Stavropoulos, A., Varras, M., Vasilakaki, T., Varra, V., Varra, F., Tsavari, A., Nonni, A., Kavantzas, N., Lazaris, A. C."Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression". Oncology Letters 20.2 (2020): 1033-1054.
Chicago
Stavropoulos, A., Varras, M., Vasilakaki, T., Varra, V., Varra, F., Tsavari, A., Nonni, A., Kavantzas, N., Lazaris, A. C."Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression". Oncology Letters 20, no. 2 (2020): 1033-1054. https://doi.org/10.3892/ol.2020.11690
Copy and paste a formatted citation
x
Spandidos Publications style
Stavropoulos A, Varras M, Vasilakaki T, Varra VK, Varra FN, Tsavari A, Nonni A, Kavantzas N and Lazaris AC: Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression. Oncol Lett 20: 1033-1054, 2020.
APA
Stavropoulos, A., Varras, M., Vasilakaki, T., Varra, V., Varra, F., Tsavari, A. ... Lazaris, A.C. (2020). Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression. Oncology Letters, 20, 1033-1054. https://doi.org/10.3892/ol.2020.11690
MLA
Stavropoulos, A., Varras, M., Vasilakaki, T., Varra, V., Varra, F., Tsavari, A., Nonni, A., Kavantzas, N., Lazaris, A. C."Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression". Oncology Letters 20.2 (2020): 1033-1054.
Chicago
Stavropoulos, A., Varras, M., Vasilakaki, T., Varra, V., Varra, F., Tsavari, A., Nonni, A., Kavantzas, N., Lazaris, A. C."Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression". Oncology Letters 20, no. 2 (2020): 1033-1054. https://doi.org/10.3892/ol.2020.11690
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