1
|
Ferlay J, Soerjomataram I, Dikshit R, Eser
S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer
incidence and mortality worldwide: Sources, methods and major
patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015.
View Article : Google Scholar : PubMed/NCBI
|
2
|
Norollahi SE, Alipour M, Rashidy-Pour A,
Samadani AA and Larijani LV: Regulatory fluctuation of WNT16 gene
expression is associated with human gastric adenocarcinoma. J
Gastrointest Cancer. 50:42–47. 2017. View Article : Google Scholar
|
3
|
Nashimoto A, Akazawa K, Isobe Y, Miyashiro
I, Katai H, Kodera Y, Tsujitani S, Seto Y, Furukawa H, Oda I, et
al: Gastric cancer treated in 2002 in Japan: 2009 annual report of
the JGCA nationwide registry. Gastric Cancer. 16:1–27. 2013.
View Article : Google Scholar : PubMed/NCBI
|
4
|
Theuer CP, Kurosaki T, Ziogas A, Butler J
and Anton-Culver H: Asian patients with gastric carcinoma in the
United States exhibit unique clinical features and superior overall
and cancer specific survival rates. Cancer. 89:1883–1892. 2000.
View Article : Google Scholar : PubMed/NCBI
|
5
|
Fraga MF, Ballestar E, Villar-Garea A,
Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S,
Petrie K, et al: Loss of acetylation at Lys16 and trimethylation at
Lys20 of histone H4 is a common hallmark of human cancer. Nat
Genet. 37:391–400. 2005. View
Article : Google Scholar : PubMed/NCBI
|
6
|
Wood LD, Parsons DW, Jones S, Lin J,
Sjöblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, et al: The
genomic landscapes of human breast and colorectal cancers. Science.
318:1108–1113. 2007. View Article : Google Scholar : PubMed/NCBI
|
7
|
Benard A, Goossens-Beumer IJ, van Hoesel
AQ, de Graaf W, Horati H, Putter H, Zeestraten EC, van de Velde CJ
and Kuppen PJ: Histone trimethylation at H3K4, H3K9 and H4K20
correlates with patient survival and tumor recurrence in
early-stage colon cancer. BMC Cancer. 14:5312014. View Article : Google Scholar : PubMed/NCBI
|
8
|
Tachibana M, Ueda J, Fukuda M, Takeda N,
Ohta T, Iwanari H, Sakihama T, Kodama T, Hamakubo T and Shinkai Y:
Histone methyltransferases G9a and GLP form heteromeric complexes
and are both crucial for methylation of euchromatin at H3-K9. Genes
Dev. 19:815–826. 2005. View Article : Google Scholar : PubMed/NCBI
|
9
|
Dawson MA and Kouzarides T: Cancer
epigenetics: From mechanism to therapy. Cell. 150:12–27. 2012.
View Article : Google Scholar : PubMed/NCBI
|
10
|
Tachibana M, Sugimoto K, Nozaki M, Ueda J,
Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, et al: G9a
histone methyltransferase plays a dominant role in euchromatic
histone H3 lysine 9 methylation and is essential for early
embryogenesis. Genes Dev. 16:1779–1791. 2002. View Article : Google Scholar : PubMed/NCBI
|
11
|
Barski A, Cuddapah S, Cui K, Roh TY,
Schones DE, Wang Z, Wei G, Chepelev I and Zhao K: High-resolution
profiling of histone methylations in the human genome. Cell.
129:823–837. 2007. View Article : Google Scholar : PubMed/NCBI
|
12
|
Scheer S and Zaph C: The Lysine
Methyltransferase G9a in Immune Cell Differentiation and Function.
Front Immunol. 8:4292017. View Article : Google Scholar : PubMed/NCBI
|
13
|
Tian YF, Wang HC, Luo CW, Hung WC, Lin YH,
Chen TY, Li CF, Lin CY and Pan MR: Preprogramming therapeutic
response of PI3K/mTOR dual inhibitor via the regulation of EHMT2
and p27 in pancreatic cancer. Am J Cancer Res. 8:1812–1822.
2018.PubMed/NCBI
|
14
|
Casciello F, Al-Ejeh F, Kelly G, Brennan
DJ, Ngiow SF, Young A, Stoll T, Windloch K, Hill MM, Smyth MJ,
Gannon F and Lee JS: G9a drives hypoxia-mediated gene repression
for breast cancer cell survival and tumorigenesis. Proc Natl Acad
Sci U S A. 114:7077–7082. 2017. View Article : Google Scholar : PubMed/NCBI
|
15
|
Kim K, Son MY, Jung CR, Kim DS and Cho HS:
EHMT2 is a metastasis regulator in breast cancer. Biochem Biophys
Res Commun. 496:758–762. 2018. View Article : Google Scholar : PubMed/NCBI
|
16
|
Huang T, Zhang P, Li W, Zhao T, Zhang Z,
Chen S, Yang Y, Feng Y, Li F, Shirley Liu X, Zhang L, Jiang G and
Zhang F: G9A promotes tumor cell growth and invasion by silencing
CASP1 in non-small-cell lung cancer cells. Cell Death Dis.
8:e27262017. View Article : Google Scholar : PubMed/NCBI
|
17
|
Wang L, Dong X, Ren Y, Luo J, Liu P, Su D
and Yang X: Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC
by epigenetically regulating the PTEN/AKT signaling pathway. Cell
Death Dis. 9:1292018. View Article : Google Scholar : PubMed/NCBI
|
18
|
Qin J, Li Q, Zeng Z, Wu P, Jiang Y, Luo T,
Ji X, Zhang Q, Hao Y and Chen L: Increased expression of G9A
contributes to carcinogenesis and indicates poor prognosis in
hepatocellular carcinoma. Oncol Lett. 15:9757–9765. 2018.PubMed/NCBI
|
19
|
Qin J, Zeng Z, Luo T, Li Q, Hao Y and Chen
L: Clinicopathological significance of G9A expression in colorectal
carcinoma. Oncol Lett. 15:8611–8619. 2018.PubMed/NCBI
|
20
|
Lee SH, Kim J, Kim WH and Lee YM: Hypoxic
silencing of tumor suppressor RUNX3 by histone modification in
gastric cancer cells. Oncogene. 28:184–194. 2009. View Article : Google Scholar : PubMed/NCBI
|
21
|
Renneville A, Van Galen P, Canver MC,
McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE,
Orkin SH, Bauer DE, et al: EHMT1 and EHMT2 inhibition induces fetal
hemoglobin expression. Blood. 126:1930–1939. 2015. View Article : Google Scholar : PubMed/NCBI
|
22
|
Cui H, Hu Y, Guo D, Zhang A, Gu Y, Zhang
S, Zhao C, Gong P, Shen X, Li Y, et al: DNA methyltransferase 3A
isoform b contributes to repressing E-cadherin through cooperation
of DNA methylation and H3K27/H3K9 methylation in EMT-related
metastasis of gastric cancer. Oncogene. 37:4358–4371. 2018.
View Article : Google Scholar : PubMed/NCBI
|
23
|
Hu L, Zang MD, Wang HX, Zhang BG, Wang ZQ,
Fan ZY, Wu H, Li JF, Su LP, Yan M, et al: G9A promotes gastric
cancer metastasis by upregulating ITGB3 in a SET domain-independent
manner. Cell Death Dis. 9:2782018. View Article : Google Scholar : PubMed/NCBI
|
24
|
Zhang C, Wei S, Hu J and Xiong Z:
Upregulated expression of G9a is correlated with poor prognosis of
gastric cancer patients. Medicine (Baltimore). 98:e182122019.
View Article : Google Scholar : PubMed/NCBI
|
25
|
Li Y, Guo D, Sun R, Chen P, Qian Q and Fan
H: Methylation patterns of Lys9 and Lys27 on histone H3 correlate
with patient outcome in gastric cancer. Dig Dis Sci. 64:439–446.
2019. View Article : Google Scholar : PubMed/NCBI
|
26
|
Lee KH, Park JW, Sung HS, Choi YJ, Kim WH,
Lee HS, Chung HJ, Shin HW, Cho CH, Kim TY, et al: PHF2 histone
demethylase acts as a tumor suppressor in association with p53 in
cancer. Oncogene. 34:2897–2909. 2015. View Article : Google Scholar : PubMed/NCBI
|
27
|
Ji X, Bu ZD, Yan Y, Li ZY, Wu AW, Zhang
LH, Zhang J, Wu XJ, Zong XL, Li SX, Shan F, et al: The 8th edition
of the American Joint Committee on Cancer tumor-node-metastasis
staging system for gastric cancer is superior to the 7th edition:
results from a Chinese mono-institutional study of 1663 patients.
Gastric Cancer. 21:643–652. 2018. View Article : Google Scholar : PubMed/NCBI
|
28
|
Axiotis CA, Monteagudo C, Merino MJ,
LaPorte N and Neumann RD: Immunohistochemical detection of
P-glycoprotein in endometrial adenocarcinoma. Am J Pathol.
138:799–806. 1991.PubMed/NCBI
|
29
|
Fisher KE, Cohen C, Siddiqui MT, Palma JF,
Lipford EH III and Longshore JW: Accurate detection of BRAF p.V600E
mutations in challenging melanoma specimens requires stringent
immunohistochemistry scoring criteria or sensitive molecular
assays. Hum Pathol. 45:2281–2293. 2014. View Article : Google Scholar : PubMed/NCBI
|
30
|
Sina AA, Carrascosa LG, Liang Z, Grewal
YS, Wardiana A, Shiddiky MJA, Gardiner RA, Samaratunga H, Gandhi
MK, Scott RJ, et al: Epigenetically reprogrammed methylation
landscape drives the DNA self-assembly and serves as a universal
cancer biomarker. Nat Commun. 9:49152018. View Article : Google Scholar : PubMed/NCBI
|
31
|
Noberini R, Osti D, Miccolo C, Richichi C,
Lupia M, Corleone G, Hong SP, Colombo P, Pollo B, Fornasari L, et
al: Extensive and systematic rewiring of histone post-translational
modifications in cancer model systems. Nucleic Acids Res.
46:3817–3832. 2018. View Article : Google Scholar : PubMed/NCBI
|
32
|
Wu Q, Lian JB, Stein JL, Stein GS,
Nickerson JA and Imbalzano AN: The BRG1 ATPase of human SWI/SNF
chromatin remodeling enzymes as a driver of cancer. Epigenomics.
9:919–931. 2017. View Article : Google Scholar : PubMed/NCBI
|
33
|
Kumar R, Li DQ, Müller S and Knapp S:
Epigenomic regulation of oncogenesis by chromatin remodeling.
Oncogene. 35:4423–4436. 2016. View Article : Google Scholar : PubMed/NCBI
|
34
|
Ma Y, Yang Y, Wang F, Moyer MP, Wei Q,
Zhang P, Yang Z, Liu W, Zhang H, Chen N, et al: Long non-coding RNA
CCAL regulates colorectal cancer progression by activating
Wnt/β-catenin signalling pathway via suppression of activator
protein 2α. Gut. 65:1494–1504. 2016. View Article : Google Scholar : PubMed/NCBI
|
35
|
Tahara T and Arisawa T: DNA methylation as
a molecular biomarker in gastric cancer. Epigenomics. 7:475–486.
2015. View
Article : Google Scholar : PubMed/NCBI
|
36
|
Lomberk G, Blum Y, Nicolle R, Nair A,
Gaonkar KS, Marisa L, Mathison A, Sun Z, Yan H, Elarouci N, et al:
Distinct epigenetic landscapes underlie the pathobiology of
pancreatic cancer subtypes. Nat Commun. 9:19782018. View Article : Google Scholar : PubMed/NCBI
|
37
|
Tvardovskiy A, Schwämmle V, Kempf SJ,
Rogowska-Wrzesinska A and Jensen ON: Accumulation of histone
variant H3.3 with age is associated with profound changes in the
histone methylation landscape. Nucleic Acids Res. 45:9272–9289.
2017. View Article : Google Scholar : PubMed/NCBI
|
38
|
Okugawa Y, Grady WM and Goel A: Epigenetic
alterations in colorectal cancer: Emerging biomarkers.
Gastroenterology. 149:1204–1225 e12. 2015. View Article : Google Scholar : PubMed/NCBI
|
39
|
Costa-Pinheiro P, Montezuma D, Henrique R
and Jerónimo C: Diagnostic and prognostic epigenetic biomarkers in
cancer. Epigenomics. 7:1003–1015. 2015. View Article : Google Scholar : PubMed/NCBI
|
40
|
Gu L, Frommel SC, Oakes CC, Simon R, Grupp
K, Gerig CY, Bär D, Robinson MD, Baer C, Weiss M, et al ICGC
Project on Early Onset Prostate Cancer, : BAZ2A (TIP5) is involved
in epigenetic alterations in prostate cancer and its overexpression
predicts disease recurrence. Nat Genet. 47:22–30. 2015. View Article : Google Scholar : PubMed/NCBI
|
41
|
Brown SE, Campbell RD and Sanderson CM:
Novel NG36/G9a gene products encoded within the human and mouse MHC
class III regions. Mamm Genome. 12:916–924. 2001. View Article : Google Scholar : PubMed/NCBI
|
42
|
Wang YF, Zhang J, Su Y, Shen YY, Jiang DX,
Hou YY, Geng MY, Ding J and Chen Y: G9a regulates breast cancer
growth by modulating iron homeostasis through the repression of
ferroxidase hephaestin. Nat Commun. 8:2742017. View Article : Google Scholar : PubMed/NCBI
|
43
|
Wei L, Chiu DK, Tsang FH, Law CT, Cheng
CL, Au SL, Lee JM, Wong CC, Ng IO and Wong CM: Histone
methyltransferase G9a promotes liver cancer development by
epigenetic silencing of tumor suppressor gene RARRES3. J Hepatol.
67:758–769. 2017. View Article : Google Scholar : PubMed/NCBI
|
44
|
Mayr C, Helm K, Jakab M, Ritter M,
Shrestha R, Makaju R, Wagner A, Pichler M, Beyreis M, Staettner S,
et al: The histone methyltransferase G9a: A new therapeutic target
in biliary tract cancer. Hum Pathol. 72:117–126. 2018. View Article : Google Scholar : PubMed/NCBI
|
45
|
Casciello F, Al-Ejeh F, Kelly G, Brennan
DJ, Ngiow SF, Young A, Stoll T, Windloch K, Hill MM, Smyth MJ, et
al: G9a drives hypoxia-mediated gene repression for breast cancer
cell survival and tumorigenesis. Proc Natl Acad Sci USA.
114:7077–7082. 2017. View Article : Google Scholar : PubMed/NCBI
|
46
|
Salzberg AC, Harris-Becker A, Popova EY,
Keasey N, Loughran TP, Claxton DF and Grigoryev SA: Genome-wide
mapping of histone H3K9me2 in acute myeloid leukemia reveals large
chromosomal domains associated with massive gene silencing and
sites of genome instability. PLoS One. 12:e01737232017. View Article : Google Scholar : PubMed/NCBI
|
47
|
Dong C, Wu Y, Yao J, Wang Y, Yu Y,
Rychahou PG, Evers BM and Zhou BP: G9a interacts with Snail and is
critical for Snail-mediated E-cadherin repression in human breast
cancer. J Clin Invest. 122:1469–1486. 2012. View Article : Google Scholar : PubMed/NCBI
|
48
|
Liu S, Ye D, Guo W, Yu W, He Y, Hu J, Wang
Y, Zhang L, Liao Y, Song H, et al: G9a is essential for
EMT-mediated metastasis and maintenance of cancer stem cell-like
characters in head and neck squamous cell carcinoma. Oncotarget.
6:6887–6901. 2015. View Article : Google Scholar : PubMed/NCBI
|
49
|
Ebbers L, Runge K and Nothwang HG:
Differential patterns of histone methylase EHMT2 and its catalyzed
histone modifications H3K9me1 and H3K9me2 during maturation of
central auditory system. Cell Tissue Res. 365:247–264. 2016.
View Article : Google Scholar : PubMed/NCBI
|
50
|
Olsen JB, Wong L, Deimling S, Miles A, Guo
H, Li Y, Zhang Z, Greenblatt JF, Emili A and Tropepe V: G9a and
ZNF644 physically associate to suppress progenitor gene expression
during neurogenesis. Stem Cell Reports. 7:454–470. 2016. View Article : Google Scholar : PubMed/NCBI
|
51
|
Sridharan R, Gonzales-Cope M, Chronis C,
Bonora G, McKee R, Huang C, Patel S, Lopez D, Mishra N, Pellegrini
M, et al: Proteomic and genomic approaches reveal critical
functions of H3K9 methylation and heterochromatin protein-1γ in
reprogramming to pluripotency. Nat Cell Biol. 15:872–882. 2013.
View Article : Google Scholar : PubMed/NCBI
|
52
|
Seligson DB, Horvath S, McBrian MA, Mah V,
Yu H, Tze S, Wang Q, Chia D, Goodglick L and Kurdistani SK: Global
levels of histone modifications predict prognosis in different
cancers. Am J Pathol. 174:1619–1628. 2009. View Article : Google Scholar : PubMed/NCBI
|
53
|
Mosashvilli D, Kahl P, Mertens C,
Holzapfel S, Rogenhofer S, Hauser S, Büttner R, Von Ruecker A,
Müller SC and Ellinger J: Global histone acetylation levels:
Prognostic relevance in patients with renal cell carcinoma. Cancer
Sci. 101:2664–2669. 2010. View Article : Google Scholar : PubMed/NCBI
|
54
|
Lin X, Huang Y, Zou Y, Chen X and Ma X:
Depletion of G9a gene induces cell apoptosis in human gastric
carcinoma. Oncol Rep. 35:3041–3049. 2016. View Article : Google Scholar : PubMed/NCBI
|