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Increased expression of EHMT2 associated with H3K9me2 level contributes to the poor prognosis of gastric cancer

  • Authors:
    • Ping Chen
    • Qi Qian
    • Zhiyuan Zhu
    • Xiaohui Shen
    • Shenling Yu
    • Zhenghong Yu
    • Rui Sun
    • Yiping Li
    • Didi Guo
    • Hong Fan
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Yancheng First People's Hospital, Yancheng, Jiangsu 224005, P.R. China, Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, P.R. China, Department of Pathology, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1734-1742
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    Published online on: June 5, 2020
       https://doi.org/10.3892/ol.2020.11694
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Abstract

Di‑methylated lysine 9 of histone H3 (H3K9me2), regulated by histone methyltransferases, is involved in the epigenetic regulation of tumor‑associated genes. The present study aimed to evaluate whether the H3K9me2 methylation level is associated with the expression level of euchromatic histone lysine methyltransferase 2 (EHMT2) in the prognosis of gastric cancer (GC). H3K9me2 methylation level and EHMT2 expression level were detected by immunohistochemistry in 118 GC samples. The clinicopathological significance of H3K9me2 and EHMT2 in patients with GC was assessed using a paired Student's t‑test, χ2 test, Kaplan‑Meier analysis with a log‑rank test and Cox's proportional hazard analysis. Strong positive immunostaining of H3K9me2 and EHMT2 was observed in cancerous tissues compared with adjacent non‑cancerous tissues. Positive immunostaining of EHMT2 and H3K9me2 was associated with lymph node metastasis, pathological grade and tumor‑node‑metastasis stage. H3K9me2 expression level was increased in tumor tissue and associated with worse specific‑disease and disease‑free survival time. In addition, EHMT2 protein expression levels were associated with the expression levels of H3K9me2. Low expression levels of H3K9me2 and EHMT2 predicted a better prognosis of patients with GC. The survival time of patients with a high expression of H3K9me2 and/or EHMT2 was significantly shorter compared with that of the patients with a low expression of H3K9me2 and/or EHMT2. In conclusion, an overexpression pattern of H3K9me2 and/or EHMT2 may be associated with clinicopathological features of GC and may be predictor markers of progression and prognosis in patients with GC, in addition to putative therapeutic targets.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Norollahi SE, Alipour M, Rashidy-Pour A, Samadani AA and Larijani LV: Regulatory fluctuation of WNT16 gene expression is associated with human gastric adenocarcinoma. J Gastrointest Cancer. 50:42–47. 2017. View Article : Google Scholar

3 

Nashimoto A, Akazawa K, Isobe Y, Miyashiro I, Katai H, Kodera Y, Tsujitani S, Seto Y, Furukawa H, Oda I, et al: Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry. Gastric Cancer. 16:1–27. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Theuer CP, Kurosaki T, Ziogas A, Butler J and Anton-Culver H: Asian patients with gastric carcinoma in the United States exhibit unique clinical features and superior overall and cancer specific survival rates. Cancer. 89:1883–1892. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, et al: Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet. 37:391–400. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, et al: The genomic landscapes of human breast and colorectal cancers. Science. 318:1108–1113. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Benard A, Goossens-Beumer IJ, van Hoesel AQ, de Graaf W, Horati H, Putter H, Zeestraten EC, van de Velde CJ and Kuppen PJ: Histone trimethylation at H3K4, H3K9 and H4K20 correlates with patient survival and tumor recurrence in early-stage colon cancer. BMC Cancer. 14:5312014. View Article : Google Scholar : PubMed/NCBI

8 

Tachibana M, Ueda J, Fukuda M, Takeda N, Ohta T, Iwanari H, Sakihama T, Kodama T, Hamakubo T and Shinkai Y: Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. 19:815–826. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Dawson MA and Kouzarides T: Cancer epigenetics: From mechanism to therapy. Cell. 150:12–27. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, et al: G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 16:1779–1791. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, Wei G, Chepelev I and Zhao K: High-resolution profiling of histone methylations in the human genome. Cell. 129:823–837. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Scheer S and Zaph C: The Lysine Methyltransferase G9a in Immune Cell Differentiation and Function. Front Immunol. 8:4292017. View Article : Google Scholar : PubMed/NCBI

13 

Tian YF, Wang HC, Luo CW, Hung WC, Lin YH, Chen TY, Li CF, Lin CY and Pan MR: Preprogramming therapeutic response of PI3K/mTOR dual inhibitor via the regulation of EHMT2 and p27 in pancreatic cancer. Am J Cancer Res. 8:1812–1822. 2018.PubMed/NCBI

14 

Casciello F, Al-Ejeh F, Kelly G, Brennan DJ, Ngiow SF, Young A, Stoll T, Windloch K, Hill MM, Smyth MJ, Gannon F and Lee JS: G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis. Proc Natl Acad Sci U S A. 114:7077–7082. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Kim K, Son MY, Jung CR, Kim DS and Cho HS: EHMT2 is a metastasis regulator in breast cancer. Biochem Biophys Res Commun. 496:758–762. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Huang T, Zhang P, Li W, Zhao T, Zhang Z, Chen S, Yang Y, Feng Y, Li F, Shirley Liu X, Zhang L, Jiang G and Zhang F: G9A promotes tumor cell growth and invasion by silencing CASP1 in non-small-cell lung cancer cells. Cell Death Dis. 8:e27262017. View Article : Google Scholar : PubMed/NCBI

17 

Wang L, Dong X, Ren Y, Luo J, Liu P, Su D and Yang X: Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway. Cell Death Dis. 9:1292018. View Article : Google Scholar : PubMed/NCBI

18 

Qin J, Li Q, Zeng Z, Wu P, Jiang Y, Luo T, Ji X, Zhang Q, Hao Y and Chen L: Increased expression of G9A contributes to carcinogenesis and indicates poor prognosis in hepatocellular carcinoma. Oncol Lett. 15:9757–9765. 2018.PubMed/NCBI

19 

Qin J, Zeng Z, Luo T, Li Q, Hao Y and Chen L: Clinicopathological significance of G9A expression in colorectal carcinoma. Oncol Lett. 15:8611–8619. 2018.PubMed/NCBI

20 

Lee SH, Kim J, Kim WH and Lee YM: Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. Oncogene. 28:184–194. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, et al: EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression. Blood. 126:1930–1939. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Cui H, Hu Y, Guo D, Zhang A, Gu Y, Zhang S, Zhao C, Gong P, Shen X, Li Y, et al: DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer. Oncogene. 37:4358–4371. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Hu L, Zang MD, Wang HX, Zhang BG, Wang ZQ, Fan ZY, Wu H, Li JF, Su LP, Yan M, et al: G9A promotes gastric cancer metastasis by upregulating ITGB3 in a SET domain-independent manner. Cell Death Dis. 9:2782018. View Article : Google Scholar : PubMed/NCBI

24 

Zhang C, Wei S, Hu J and Xiong Z: Upregulated expression of G9a is correlated with poor prognosis of gastric cancer patients. Medicine (Baltimore). 98:e182122019. View Article : Google Scholar : PubMed/NCBI

25 

Li Y, Guo D, Sun R, Chen P, Qian Q and Fan H: Methylation patterns of Lys9 and Lys27 on histone H3 correlate with patient outcome in gastric cancer. Dig Dis Sci. 64:439–446. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Lee KH, Park JW, Sung HS, Choi YJ, Kim WH, Lee HS, Chung HJ, Shin HW, Cho CH, Kim TY, et al: PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer. Oncogene. 34:2897–2909. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Ji X, Bu ZD, Yan Y, Li ZY, Wu AW, Zhang LH, Zhang J, Wu XJ, Zong XL, Li SX, Shan F, et al: The 8th edition of the American Joint Committee on Cancer tumor-node-metastasis staging system for gastric cancer is superior to the 7th edition: results from a Chinese mono-institutional study of 1663 patients. Gastric Cancer. 21:643–652. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Axiotis CA, Monteagudo C, Merino MJ, LaPorte N and Neumann RD: Immunohistochemical detection of P-glycoprotein in endometrial adenocarcinoma. Am J Pathol. 138:799–806. 1991.PubMed/NCBI

29 

Fisher KE, Cohen C, Siddiqui MT, Palma JF, Lipford EH III and Longshore JW: Accurate detection of BRAF p.V600E mutations in challenging melanoma specimens requires stringent immunohistochemistry scoring criteria or sensitive molecular assays. Hum Pathol. 45:2281–2293. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Sina AA, Carrascosa LG, Liang Z, Grewal YS, Wardiana A, Shiddiky MJA, Gardiner RA, Samaratunga H, Gandhi MK, Scott RJ, et al: Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker. Nat Commun. 9:49152018. View Article : Google Scholar : PubMed/NCBI

31 

Noberini R, Osti D, Miccolo C, Richichi C, Lupia M, Corleone G, Hong SP, Colombo P, Pollo B, Fornasari L, et al: Extensive and systematic rewiring of histone post-translational modifications in cancer model systems. Nucleic Acids Res. 46:3817–3832. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Wu Q, Lian JB, Stein JL, Stein GS, Nickerson JA and Imbalzano AN: The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer. Epigenomics. 9:919–931. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Kumar R, Li DQ, Müller S and Knapp S: Epigenomic regulation of oncogenesis by chromatin remodeling. Oncogene. 35:4423–4436. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Ma Y, Yang Y, Wang F, Moyer MP, Wei Q, Zhang P, Yang Z, Liu W, Zhang H, Chen N, et al: Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α. Gut. 65:1494–1504. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Tahara T and Arisawa T: DNA methylation as a molecular biomarker in gastric cancer. Epigenomics. 7:475–486. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Lomberk G, Blum Y, Nicolle R, Nair A, Gaonkar KS, Marisa L, Mathison A, Sun Z, Yan H, Elarouci N, et al: Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes. Nat Commun. 9:19782018. View Article : Google Scholar : PubMed/NCBI

37 

Tvardovskiy A, Schwämmle V, Kempf SJ, Rogowska-Wrzesinska A and Jensen ON: Accumulation of histone variant H3.3 with age is associated with profound changes in the histone methylation landscape. Nucleic Acids Res. 45:9272–9289. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Okugawa Y, Grady WM and Goel A: Epigenetic alterations in colorectal cancer: Emerging biomarkers. Gastroenterology. 149:1204–1225 e12. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Costa-Pinheiro P, Montezuma D, Henrique R and Jerónimo C: Diagnostic and prognostic epigenetic biomarkers in cancer. Epigenomics. 7:1003–1015. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Gu L, Frommel SC, Oakes CC, Simon R, Grupp K, Gerig CY, Bär D, Robinson MD, Baer C, Weiss M, et al ICGC Project on Early Onset Prostate Cancer, : BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence. Nat Genet. 47:22–30. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Brown SE, Campbell RD and Sanderson CM: Novel NG36/G9a gene products encoded within the human and mouse MHC class III regions. Mamm Genome. 12:916–924. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Wang YF, Zhang J, Su Y, Shen YY, Jiang DX, Hou YY, Geng MY, Ding J and Chen Y: G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin. Nat Commun. 8:2742017. View Article : Google Scholar : PubMed/NCBI

43 

Wei L, Chiu DK, Tsang FH, Law CT, Cheng CL, Au SL, Lee JM, Wong CC, Ng IO and Wong CM: Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3. J Hepatol. 67:758–769. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Mayr C, Helm K, Jakab M, Ritter M, Shrestha R, Makaju R, Wagner A, Pichler M, Beyreis M, Staettner S, et al: The histone methyltransferase G9a: A new therapeutic target in biliary tract cancer. Hum Pathol. 72:117–126. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Casciello F, Al-Ejeh F, Kelly G, Brennan DJ, Ngiow SF, Young A, Stoll T, Windloch K, Hill MM, Smyth MJ, et al: G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis. Proc Natl Acad Sci USA. 114:7077–7082. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Salzberg AC, Harris-Becker A, Popova EY, Keasey N, Loughran TP, Claxton DF and Grigoryev SA: Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability. PLoS One. 12:e01737232017. View Article : Google Scholar : PubMed/NCBI

47 

Dong C, Wu Y, Yao J, Wang Y, Yu Y, Rychahou PG, Evers BM and Zhou BP: G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest. 122:1469–1486. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Liu S, Ye D, Guo W, Yu W, He Y, Hu J, Wang Y, Zhang L, Liao Y, Song H, et al: G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma. Oncotarget. 6:6887–6901. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Ebbers L, Runge K and Nothwang HG: Differential patterns of histone methylase EHMT2 and its catalyzed histone modifications H3K9me1 and H3K9me2 during maturation of central auditory system. Cell Tissue Res. 365:247–264. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Olsen JB, Wong L, Deimling S, Miles A, Guo H, Li Y, Zhang Z, Greenblatt JF, Emili A and Tropepe V: G9a and ZNF644 physically associate to suppress progenitor gene expression during neurogenesis. Stem Cell Reports. 7:454–470. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Sridharan R, Gonzales-Cope M, Chronis C, Bonora G, McKee R, Huang C, Patel S, Lopez D, Mishra N, Pellegrini M, et al: Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency. Nat Cell Biol. 15:872–882. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Seligson DB, Horvath S, McBrian MA, Mah V, Yu H, Tze S, Wang Q, Chia D, Goodglick L and Kurdistani SK: Global levels of histone modifications predict prognosis in different cancers. Am J Pathol. 174:1619–1628. 2009. View Article : Google Scholar : PubMed/NCBI

53 

Mosashvilli D, Kahl P, Mertens C, Holzapfel S, Rogenhofer S, Hauser S, Büttner R, Von Ruecker A, Müller SC and Ellinger J: Global histone acetylation levels: Prognostic relevance in patients with renal cell carcinoma. Cancer Sci. 101:2664–2669. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Lin X, Huang Y, Zou Y, Chen X and Ma X: Depletion of G9a gene induces cell apoptosis in human gastric carcinoma. Oncol Rep. 35:3041–3049. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen P, Qian Q, Zhu Z, Shen X, Yu S, Yu Z, Sun R, Li Y, Guo D, Fan H, Fan H, et al: Increased expression of EHMT2 associated with H3K9me2 level contributes to the poor prognosis of gastric cancer . Oncol Lett 20: 1734-1742, 2020.
APA
Chen, P., Qian, Q., Zhu, Z., Shen, X., Yu, S., Yu, Z. ... Fan, H. (2020). Increased expression of EHMT2 associated with H3K9me2 level contributes to the poor prognosis of gastric cancer . Oncology Letters, 20, 1734-1742. https://doi.org/10.3892/ol.2020.11694
MLA
Chen, P., Qian, Q., Zhu, Z., Shen, X., Yu, S., Yu, Z., Sun, R., Li, Y., Guo, D., Fan, H."Increased expression of EHMT2 associated with H3K9me2 level contributes to the poor prognosis of gastric cancer ". Oncology Letters 20.2 (2020): 1734-1742.
Chicago
Chen, P., Qian, Q., Zhu, Z., Shen, X., Yu, S., Yu, Z., Sun, R., Li, Y., Guo, D., Fan, H."Increased expression of EHMT2 associated with H3K9me2 level contributes to the poor prognosis of gastric cancer ". Oncology Letters 20, no. 2 (2020): 1734-1742. https://doi.org/10.3892/ol.2020.11694
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Spandidos Publications style
Chen P, Qian Q, Zhu Z, Shen X, Yu S, Yu Z, Sun R, Li Y, Guo D, Fan H, Fan H, et al: Increased expression of EHMT2 associated with H3K9me2 level contributes to the poor prognosis of gastric cancer . Oncol Lett 20: 1734-1742, 2020.
APA
Chen, P., Qian, Q., Zhu, Z., Shen, X., Yu, S., Yu, Z. ... Fan, H. (2020). Increased expression of EHMT2 associated with H3K9me2 level contributes to the poor prognosis of gastric cancer . Oncology Letters, 20, 1734-1742. https://doi.org/10.3892/ol.2020.11694
MLA
Chen, P., Qian, Q., Zhu, Z., Shen, X., Yu, S., Yu, Z., Sun, R., Li, Y., Guo, D., Fan, H."Increased expression of EHMT2 associated with H3K9me2 level contributes to the poor prognosis of gastric cancer ". Oncology Letters 20.2 (2020): 1734-1742.
Chicago
Chen, P., Qian, Q., Zhu, Z., Shen, X., Yu, S., Yu, Z., Sun, R., Li, Y., Guo, D., Fan, H."Increased expression of EHMT2 associated with H3K9me2 level contributes to the poor prognosis of gastric cancer ". Oncology Letters 20, no. 2 (2020): 1734-1742. https://doi.org/10.3892/ol.2020.11694
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