Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma

  • Authors:
    • Jinju Park
    • Woochan Lee
    • Sangil Yun
    • Saet Pyoul Kim
    • Kyung Hyun Kim
    • Jong‑Il Kim
    • Seung‑Ki Kim
    • Kyu‑Chang Wang
    • Ji Yeoun Lee
  • View Affiliations / Copyright

    Affiliations: Neural Development and Anomaly Laboratory, Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea, Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 03080, Republic of Korea
    Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1989-1998
    |
    Published online on: June 5, 2020
       https://doi.org/10.3892/ol.2020.11699
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Diffuse intrinsic pontine glioma (DIPG) is one of the most lethal childhood brain tumors. This tumor is unique because it is detected exclusively in the ventral pons of patients aged between 6 and 7 years, which suggests a developmental nature of its formation. Signal transducer and activator of transcription 3 (STAT3) is a critical molecule for the differentiation of neural stem cells into astrocytes during neurodevelopment. Additionally, STAT3 is associated with oncogenesis and the epithelial‑mesenchymal transition (EMT) in various types of tumor. In recent years, several studies have demonstrated the oncogenic role of STAT3 in high‑grade gliomas. However, the role of STAT3 in DIPG at the cellular level remains unknown. To assess the possible association between gliogenesis and DIPG, the expression levels of various molecules participating in the differentiation of neural stem cells were compared between normal brain control tissues and DIPG tissues using open public data. All of the screened genes exhibited significantly increased expression in DIPG tissues compared with normal tissues. As STAT3 expression was the most increased, the effect of STAT3 inhibition in a DIPG cell line was assessed via STAT3 short hairpin (sh)RNA transfection and treatment with AG490, a STAT3 inhibitor. Changes in viability, apoptosis, EMT and radiation therapy efficiency were also evaluated. Downregulation of STAT3 resulted in decreased cyclin D1 expression and cell viability, migration and invasion. Additionally, treatment with STAT3 shRNA or AG490 suppressed the EMT phenotype. Finally, when radiation was administered in combination with STAT3 inhibition, the therapeutic efficiency, assessed by cell viability and DNA damage repair, was increased. The present results suggest that STAT3 is a potential therapeutic target in DIPG, especially when combined with radiation therapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Warren KE: Diffuse intrinsic pontine glioma: Poised for progress. Front Oncol. 2:2052012. View Article : Google Scholar : PubMed/NCBI

2 

Khatua S, Sadighi ZS, Pearlman ML, Bochare S and Vats TS: Brain tumors in children-current therapies and newer directions. Indian J Pediatr. 79:922–927. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Vanan MI and Eisenstat DD: DIPG in Children-what can we learn from the past? Front Oncol. 5:2372015. View Article : Google Scholar : PubMed/NCBI

4 

Jansen MH, Van Vuurden DG, Vandertop WP and Kaspers GJ: Diffuse intrinsic pontine gliomas: A systematic update on clinical trials and biology. Cancer Treat Rev. 38:27–35. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Pollack IF, Jakacki RI, Blaney SM, Hancock ML, Kieran MW, Phillips P, Kun LE, Friedman H, Packer R, Banerjee A, et al: Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: A pediatric brain tumor consortium report. Neuro Oncol. 9:145–160. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Geoerger B, Hargrave D, Thomas F, Ndiaye A, Frappaz D, Andreiuolo F, Varlet P, Aerts I, Riccardi R, Jaspan T, et al: Innovative therapies for Children with cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors. Neuro Oncol. 13:109–118. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y, Zhu X, Qu C, Chen X, Zhang J, et al: The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet. 46:444–450. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Hall A, Giese NA and Richardson WD: Spinal cord oligodendrocytes develop from ventrally derived progenitor cells that express PDGF alpha-receptors. Development. 122:4085–4094. 1996.PubMed/NCBI

9 

Verschueren K, Dewulf N, Goumans MJ, Lonnoy O, Feijen A, Grimsby S, Vandi Spiegle K, ten Dijke P, Morén A, Vanscheeuwijck P, et al: Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis. Mech Dev. 52:109–123. 1995. View Article : Google Scholar : PubMed/NCBI

10 

Buczkowicz P, Bartels U, Bouffet E, Becher O and Hawkins C: Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: Diagnostic and therapeutic implications. Acta Neuropathol. 128:573–581. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Saratsis AM, Kambhampati M, Snyder K, Yadavilli S, Devaney JM, Harmon B, Hall J, Raabe EH, An P, Weingart M, et al: Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes. Acta Neuropathol. 127:881–895. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Achanta P, Sedora Roman NI and Quiñones-Hinojosa A: Gliomagenesis and the use of neural stem cells in brain tumor treatment. Anticancer Agents Med Chem. 10:121–130. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Levy DE and Lee CK: What does Stat3 do? J Clin Invest. 109:1143–1148. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Duncan SA, Zhong Z, Wen Z and Darnell JE Jr: STAT signaling is active during early mammalian development. Dev Dyn. 208:190–198. 1997. View Article : Google Scholar : PubMed/NCBI

15 

Wegenka UM, Buschmann J, Lütticken C, Heinrich PC and Horn F: Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level. Mol Cell Biol. 13:276–288. 1993. View Article : Google Scholar : PubMed/NCBI

16 

Levy DE and Darnell JE Jr: Stats: Transcriptional control and biological impact. Nat Rev Mol Cell Biol. 3:651–662. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W, Shen Y, Wu H, et al: DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development. 132:3345–3356. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Ma JH, Qin L and Li X: Role of STAT3 signaling pathway in breast cancer. Cell Commun Signal. 18:332020. View Article : Google Scholar : PubMed/NCBI

19 

Dutta P, Sabri N, Li J and Li WX: Role of STAT3 in lung cancer. JAKSTAT. 3:e9995032014.PubMed/NCBI

20 

Corcoran RB, Contino G, Deshpande V, Tzatsos A, Conrad C, Benes CH, Levy DE, Settleman J, Engelman JA and Bardeesy N: STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. Cancer Res. 71:5020–5029. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J and Jove R: Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science. 269:81–83. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Garcia R, Yu CL, Hudnall A, Catlett R, Nelson KL, Smithgall T, Fujita DJ, Ethier SP and Jove R: Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ. 8:1267–1276. 1997.PubMed/NCBI

23 

Lund TC, Prator PC, Medveczky MM and Medveczky PG: The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells. J Virol. 73:1689–1694. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Wen X, Lin HH, Shih HM, Kung HJ and Ann DK: Kinase activation of the non-receptor tyrosine kinase Etk/BMX alone is sufficient to transactivate STAT-mediated gene expression in salivary and lung epithelial cells. J Biol Chem. 274:38204–38210. 1999. View Article : Google Scholar : PubMed/NCBI

25 

West AJ, Tsui V, Stylli SS, Nguyen HPT, Morokoff AP, Kaye AH and Luwor RB: The role of interleukin-6-STAT3 signalling in glioblastoma. Oncol Lett. 16:4095–4104. 2018.PubMed/NCBI

26 

Ganguly D, Fan M, Yang CH, Zbytek B, Finkelstein D, Roussel MF and Pfeffer LM: The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma. Oncotarget. 9:22095–22112. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Kim JE, Patel M, Ruzevick J, Jackson CM and Lim M: STAT3 Activation in glioblastoma: Biochemical and therapeutic implications. Cancers (Basel). 6:376–395. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Ouédraogo ZG, Biau J, Kemeny JL, Morel L, Verrelle P and Chautard E: Role of STAT3 in genesis and progression of human malignant gliomas. Mol Neurobiol. 54:5780–5797. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Chang N, Ahn SH, Kong DS, Lee HW and Nam DH: The role of STAT3 in glioblastoma progression through dual influences on tumor cells and the immune microenvironment. Mol Cell Endocrinol. 451:53–65. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Chuang JH, Tung LC and Lin Y: Neural differentiation from embryonic stem cells in vitro: An overview of the signaling pathways. World J Stem Cells. 7:437–447. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, et al: Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci USA. 105:15605–15610. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Paugh BS, Broniscer A, Qu C, Miller CP, Zhang J, Tatevossian RG, Olson JM, Geyer JR, Chi SN, da Silva NS, et al: Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J Clin Oncol. 29:3999–4006. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Kumar SS, Sengupta S, Lee K, Hura N, Fuller C, DeWire M, Stevenson CB, Fouladi M and Drissi R: BMI-1 is a potential therapeutic target in diffuse intrinsic pontine glioma. Oncotarget. 8:62962–62975. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Liu ZH, Dai XM and Du B: Hes1: A key role in stemness, metastasis and multidrug resistance. Cancer Biol Ther. 16:353–359. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Kamran MZ, Patil P and Gude RP: Role of STAT3 in cancer metastasis and translational advances. Biomed Res Int. 2013:4218212013. View Article : Google Scholar : PubMed/NCBI

36 

Yang YP, Chang YL, Huang PI, Chiou GY, Tseng LM, Chiou SH, Chen MH, Chen MT, Shih YH, Chang CH, et al: Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis. J Cell Physiol. 227:976–993. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Wendt MK, Balanis N, Carlin CR and Schiemann WP: STAT3 and epithelial-mesenchymal transitions in carcinomas. JAKSTAT. 3:e289752014.PubMed/NCBI

38 

Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA and Persson AI: STAT3 blockade inhibits radiation-induced malignant progression in glioma. Cancer Res. 75:4302–4311. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY and Tweardy DJ: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 7:26307–26330. 2016. View Article : Google Scholar : PubMed/NCBI

40 

You S, Li R, Park D, Xie M, Sica GL, Cao Y, Xiao ZQ and Deng X: Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer. Mol Cancer Ther. 13:606–616. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Puget S, Philippe C, Bax DA, Job B, Varlet P, Junier MP, Andreiuolo F, Carvalho D, Reis R, Guerrini-Rousseau L, et al: Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas. PLoS One. 7:e303132012. View Article : Google Scholar : PubMed/NCBI

42 

Leslie K, Lang C, Devgan G, Azare J, Berishaj M, Gerald W, Kim YB, Paz K, Darnell JE, Albanese C, et al: Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res. 66:2544–2552. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Gu J, Li G, Sun T, Su Y, Zhang X, Shen J, Tian Z and Zhang J: Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells. J Neurooncol. 89:9–17. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Brabletz T, Kalluri R, Nieto MA and Weinberg RA: EMT in cancer. Nat Rev Cancer. 18:128–134. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Shintani Y, Okimura A, Sato K, Nakagiri T, Kadota Y, Inoue M, Sawabata N, Minami M, Ikeda N, Kawahara K, et al: Epithelial to mesenchymal transition is a determinant of sensitivity to chemoradiotherapy in non-small cell lung cancer. Ann Thorac Surg. 92:1794–1804. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Siebzehnrubl FA, Silver DJ, Tugertimur B, Deleyrolle LP, Siebzehnrubl D, Sarkisian MR, Devers KG, Yachnis AT, Kupper MD, Neal D, et al: The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Mol Med. 5:1196–1212. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Kahlert UD, Nikkhah G and Maciaczyk J: Epithelial-to-mesenchymal(−like) transition as a relevant molecular event in malignant gliomas. Cancer Lett. 331:131–138. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Meel MH, Schaper SA, Kaspers GJL and Hulleman E: Signaling pathways and mesenchymal transition in pediatric high-grade glioma. Cell Mol Life Sci. 75:871–887. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Cao F, Hata R, Zhu P, Nakashiro K and Sakanaka M: Conditional deletion of Stat3 promotes neurogenesis and inhibits astrogliogenesis in neural stem cells. Biochem Biophys Res Commun. 394:843–847. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Uddin N, Kim RK, Yoo KC, Kim YH, Cui YH, Kim IG, Suh Y and Lee SJ: Persistent activation of STAT3 by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer. Cancer Sci. 106:718–725. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Xiong H, Hong J, Du W, Lin YW, Ren LL, Wang YC, Su WY, Wang JL, Cui Y, Wang ZH and Fang JY: Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition. J Biol Chem. 287:5819–5832. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Han X, Xue X, Zhou H and Zhang G: A molecular view of the radioresistance of gliomas. Oncotarget. 8:100931–100941. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Gao L, Li F, Dong B, Zhang J, Rao Y, Cong Y, Mao B and Chen X: Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells. Int J Radiat Oncol Biol Phys. 77:1223–1231. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Yuan X, Du J, Hua S, Zhang H, Gu C, Wang J, Yang L, Huang J, Yu J and Liu F: Suppression of autophagy augments the radiosensitizing effects of STAT3 inhibition on human glioma cells. Exp Cell Res. 330:267–276. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Han TJ, Cho BJ, Choi EJ, Kim DH, Song SH, Paek SH and Kim IA: Inhibition of STAT3 enhances the radiosensitizing effect of temozolomide in glioblastoma cells in vitro and in vivo. J Neurooncol. 130:89–98. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Zang C, Liu X, Li B, He Y, Jing S, He Y, Wu W, Zhang B, Ma S, Dai W, et al: IL-6/STAT3/TWIST inhibition reverses ionizing radiation-induced EMT and radioresistance in esophageal squamous carcinoma. Oncotarget. 8:11228–11238. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Lin JC, Tsai JT, Chao TY, Ma HI and Liu WH: The STAT3/Slug axis enhances radiation-induced tumor invasion and cancer stem-like properties in radioresistant glioblastoma. Cancers (Basel). 10(pii): E5122018. View Article : Google Scholar : PubMed/NCBI

58 

Guleria A and Chandna S: ATM kinase: Much more than a DNA damage responsive protein. DNA Repair (Amst). 39:1–20. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Shen M, Xu Z, Xu W, Jiang K, Zhang F, Ding Q, Xu Z and Chen Y: Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway. J Exp Clin Cancer Res. 38:1492019. View Article : Google Scholar : PubMed/NCBI

60 

Zhang Y, Cho YY, Petersen BL, Bode AM, Zhu F and Dong Z: Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3. J Biol Chem. 278:12650–12659. 2003. View Article : Google Scholar : PubMed/NCBI

61 

Shimazaki T and Okano H: Heterochronic microRNAs in temporal specification of neural stem cells: Application toward rejuvenation. NPJ Aging Mech Dis. 2:150142016. View Article : Google Scholar : PubMed/NCBI

62 

Samanta J and Kessler JA: Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation. Development. 131:4131–4142. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Park J, Lee W, Yun S, Kim S, Kim K, Kim JI, Kim SK, Wang KC and Lee J: STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma. Oncol Lett 20: 1989-1998, 2020.
APA
Park, J., Lee, W., Yun, S., Kim, S., Kim, K., Kim, J. ... Lee, J. (2020). STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma. Oncology Letters, 20, 1989-1998. https://doi.org/10.3892/ol.2020.11699
MLA
Park, J., Lee, W., Yun, S., Kim, S., Kim, K., Kim, J., Kim, S., Wang, K., Lee, J."STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma". Oncology Letters 20.2 (2020): 1989-1998.
Chicago
Park, J., Lee, W., Yun, S., Kim, S., Kim, K., Kim, J., Kim, S., Wang, K., Lee, J."STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma". Oncology Letters 20, no. 2 (2020): 1989-1998. https://doi.org/10.3892/ol.2020.11699
Copy and paste a formatted citation
x
Spandidos Publications style
Park J, Lee W, Yun S, Kim S, Kim K, Kim JI, Kim SK, Wang KC and Lee J: STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma. Oncol Lett 20: 1989-1998, 2020.
APA
Park, J., Lee, W., Yun, S., Kim, S., Kim, K., Kim, J. ... Lee, J. (2020). STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma. Oncology Letters, 20, 1989-1998. https://doi.org/10.3892/ol.2020.11699
MLA
Park, J., Lee, W., Yun, S., Kim, S., Kim, K., Kim, J., Kim, S., Wang, K., Lee, J."STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma". Oncology Letters 20.2 (2020): 1989-1998.
Chicago
Park, J., Lee, W., Yun, S., Kim, S., Kim, K., Kim, J., Kim, S., Wang, K., Lee, J."STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma". Oncology Letters 20, no. 2 (2020): 1989-1998. https://doi.org/10.3892/ol.2020.11699
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team