Open Access

Conditional survival rate estimates of lobectomy, segmentectomy and wedge resection for stage IA1 non‑small cell lung cancer: A population‑based study

  • Authors:
    • Xiaoxi Fan
    • Yicheng Liang
    • Yunpeng Bai
    • Chunlu Yang
    • Shun Xu
  • View Affiliations

  • Published online on: June 9, 2020     https://doi.org/10.3892/ol.2020.11713
  • Pages: 1607-1618
  • Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Conditional survival rate (CSR) is defined as the dynamic possibility of survival, considering the changes in the survival risk over time. The present study aimed to compare the CSR of the surgical procedures for stage IA1 non‑small cell lung cancer (NSCLC). Overall, data for 2,535 patients with stage IA1 NSCLC after lobectomy, segmentectomy or wedge resection were obtained from the Surveillance, Epidemiology and End Results database, and the overall survival (OS) rates were subsequently compared. CSR estimates, the possibility of patients who had already survived x years, to survive further y years, was calculated as CSR=S(x+y)/S(x), where S is the survival rate at a particular point in time. A Cox regression model and propensity‑score matching were used to adjust confounding factors. There were no statistical differences in the OS among the three surgical procedures, except that OS of patients who underwent a lobectomy was improved compared with the wedge resection. The CSR of surviving to the 5th year after operation improved gradually over time. The 3‑year CSR of lobectomy or segmentectomy was higher compared with that of the wedge resection. Moreover, the 3‑year CSR of segmentectomy was higher compared with that of lobectomy from the 3rd year after surgery, particularly in some specific situations, such as female sex, patients ≥66 years old, patients with squamous cell carcinoma or patients with poor tumor differentiation. The present study is the first report to compare CSR following lobectomy, segmentectomy and wedge resection for patients with stage IA1 NSCLC, to the best of our knowledge. These findings indicated that lobectomy is the most conservative surgical procedure for stage IA1 NSCLC and raises questions regarding improved long‑term prognosis of segmentectomy in some subsets of patients.

Related Articles

Journal Cover

August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Fan X, Liang Y, Bai Y, Yang C and Xu S: Conditional survival rate estimates of lobectomy, segmentectomy and wedge resection for stage IA1 non‑small cell lung cancer: A population‑based study. Oncol Lett 20: 1607-1618, 2020
APA
Fan, X., Liang, Y., Bai, Y., Yang, C., & Xu, S. (2020). Conditional survival rate estimates of lobectomy, segmentectomy and wedge resection for stage IA1 non‑small cell lung cancer: A population‑based study. Oncology Letters, 20, 1607-1618. https://doi.org/10.3892/ol.2020.11713
MLA
Fan, X., Liang, Y., Bai, Y., Yang, C., Xu, S."Conditional survival rate estimates of lobectomy, segmentectomy and wedge resection for stage IA1 non‑small cell lung cancer: A population‑based study". Oncology Letters 20.2 (2020): 1607-1618.
Chicago
Fan, X., Liang, Y., Bai, Y., Yang, C., Xu, S."Conditional survival rate estimates of lobectomy, segmentectomy and wedge resection for stage IA1 non‑small cell lung cancer: A population‑based study". Oncology Letters 20, no. 2 (2020): 1607-1618. https://doi.org/10.3892/ol.2020.11713