Open Access

Function and regulation of F‑box/WD repeat‑containing protein 7 (Review)

  • Authors:
    • Zheng Zhang
    • Qiangsheng Hu
    • Wenyan Xu
    • Wensheng  Liu
    • Mengqi Liu
    • Qiqing  Sun
    • Zeng Ye
    • Guixiong Fan
    • Yi  Qin
    • Xiaowu Xu
    • Xianjun Yu
    • Shunrong Ji
  • View Affiliations

  • Published online on: June 11, 2020     https://doi.org/10.3892/ol.2020.11728
  • Pages: 1526-1534
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The ubiquitin‑proteasome system is an important post‑translational modification system involved in numerous biological processes, such as cell cycle regulation, gene transcription, signal transduction, apoptosis, differentiation and development. F‑box/WD repeat‑containing protein 7 (FBXW7) is one of the most studied F‑box (FBX) proteins, serving as substrate recognition component of S phase kinase‑associated protein 1‑Cullin 1‑FBX protein complexes. As a tumor suppressor, FBXW7 recognizes numerous proto‑oncoproteins and promotes their ubiquitination and subsequent proteasomal degradation. FBXW7 is regulated at different levels, leading to tunable and specific control of the activity and abundance of its substrates. Therefore, genetic mutations or decreases in its expression serve an important biological role in tumor development. In‑depth studies and identification of additional substrates targeted by FBXW7 have suggested a signaling network regulated by FBXW7, including its tumor‑inhibitory role. The present review focused on the role of FBXW7 in tumor suppression and its application in cancer therapy.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zhang, Z., Hu, Q., Xu, W., Liu, W., Liu, M., Sun, Q. ... Ji, S. (2020). Function and regulation of F‑box/WD repeat‑containing protein 7 (Review) . Oncology Letters, 20, 1526-1534. https://doi.org/10.3892/ol.2020.11728
MLA
Zhang, Z., Hu, Q., Xu, W., Liu, W., Liu, M., Sun, Q., Ye, Z., Fan, G., Qin, Y., Xu, X., Yu, X., Ji, S."Function and regulation of F‑box/WD repeat‑containing protein 7 (Review) ". Oncology Letters 20.2 (2020): 1526-1534.
Chicago
Zhang, Z., Hu, Q., Xu, W., Liu, W., Liu, M., Sun, Q., Ye, Z., Fan, G., Qin, Y., Xu, X., Yu, X., Ji, S."Function and regulation of F‑box/WD repeat‑containing protein 7 (Review) ". Oncology Letters 20, no. 2 (2020): 1526-1534. https://doi.org/10.3892/ol.2020.11728