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Protein expression profiles that underpin the preventive and therapeutic potential of Moringa oleifera Lam against azoxymethane and dextran sodium sulfate‑induced mouse colon carcinogenesis

  • Authors:
    • Phatchariya Phannasil
    • Sittiruk Roytrakul
    • Narumon Phaonakrop
    • Piengchai Kupradinun
    • Sirintip Budda
    • Chaniphun Butryee
    • Chareeporn Akekawatchai
    • Siriporn Tuntipopipat
  • View Affiliations / Copyright

    Affiliations: Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom 73170, Thailand, Funtional Ingredients and Food Innovation Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani 12120, Thailand, Section of Animal Laboratory, Research Division, National Cancer Institute, Bangkok 10400, Thailand, Food Cluster, Institute of Nutrition, Mahidol University, Nakhon Pathom 73170, Thailand, Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumthani 12121, Thailand
    Copyright: © Phannasil et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1792-1802
    |
    Published online on: June 11, 2020
       https://doi.org/10.3892/ol.2020.11730
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Abstract

Previous studies in a mouse model have indicated the anticancer potential of boiled Moringa oleifera pod (bMO)‑supplemented diets; however, its molecular mechanisms are still unclear. Therefore, the present study aimed to explore the protein expression profiles responsible for the suppressive effect of bMO supplementation on azoxymethane (AOM)/dextran sodium sulfate (DSS)‑induced mouse colon carcinogenesis. Analysis by gel electrophoresis and liquid chromatography‑tandem mass spectrophotometry demonstrated that there were 125 proteins that were differentially expressed in mouse colon tissues between 14 experimental groups of mice. The differentially expressed proteins are involved in various biological processes, such as signal transduction, metabolism, transcription and translation. Venn diagram analysis of the differentially expressed proteins was performed in six selected mouse groups, including negative control, positive control mice induced by AOM/DSS, the AOM/DSS groups receiving preventive or therapeutic bMO diets and their bMO‑supplemented control groups. This analysis identified 7 proteins; 60S acidic ribosomal protein P1 (Rplp1), fragile X mental retardation, cystatin 9, round spermatids protein, zinc finger protein 638, protein phosphatase 2C (Ppm1g) and unnamed protein product as being potentially associated with the preventive and therapeutic effects of bMO in AOM/DSS‑induced mouse colon cancer. Analysis based on the search tool for interactions of chemicals (STITCH) database predicted that Rplp1 interacted with the apoptotic and inflammatory pathways, whereas Ppm1g was associated only with inflammatory networks. This proteomic analysis revealed candidate proteins that are responsible for the effects of bMO supplementation, potentially by regulating apoptotic and inflammatory signaling networks in colorectal cancer prevention and therapy.
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1 

Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global patterns and trends in colorectal cancer incidence and mortality. Gut. 66:683–691. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Dolatkhah R, Somi MH, Kermani IA, Ghojazadeh M, Jafarabadi MA, Farassati F and Dastgiri S: Increased colorectal cancer incidence in Iran: A systematic review and meta-analysis. BMC Public Health. 15:9972015. View Article : Google Scholar : PubMed/NCBI

3 

Yin TF, Wang M, Qing Y, Lin YM and Wu D: Research progress on chemopreventive effects of phytochemicals on colorectal cancer and their mechanisms. World J Gastroenterol. 22:7058–7068. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Bradbury KE, Appleby PN and Key TJ: Fruit, vegetable, and fiber intake in relation to cancer risk: Findings from the European prospective investigation into cancer and nutrition (EPIC). Am J Clin Nutr. 100 (Suppl 1):S394–S398. 2014. View Article : Google Scholar

5 

Abdull Razis AF, Ibrahim MD and Kntayya SB: Health benefits of moringa oleifera. Asian Pac J Cancer Prev. 15:8571–8576. 2014. View Article : Google Scholar

6 

Karim NA, Ibrahim MD, Kntayya SB, Rukayadi Y, Hamid HA and Razis AFA: Moringa oleifera Lam: Targeting chemoprevention. Asian Pac J Cancer Prev. 17:3675–3686. 2016.PubMed/NCBI

7 

Leone A, Spada A, Battezzati A, Schiraldi A, Aristil J and Bertoli S: Cultivation, genetic, ethnopharmacology, phytochemistry and pharmacology of Moringa oleifera leaves: An overview. Int J Mol Sci. 16:12791–12835. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Francis JA, Jayaprakasam B, Olson LK and Nair MG: Insulin secretagogues from Moringa oleifera with cyclooxygenase enzyme and lipid peroxidation inhibitory activities. Helv Chim Acta. 87:317–326. 2004. View Article : Google Scholar

9 

Cheenpracha S, Park EJ, Yoshida WY, Barit C, Wall M, Pezzuto JM and Chang LC: Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits. Bioorg Med Chem. 18:6598–6602. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Al-Asmari AK, Albalawi SM, Athar MT, Khan AQ, Al-Shahrani H and Islam M: Moringa oleifera as an anti-cancer agent against breast and colorectal cancer cell lines. PLoS One. 10:e01358142015. View Article : Google Scholar : PubMed/NCBI

11 

Elsayed EA, Sharaf-Eldin MA and Wadaan M: In vitro evaluation of cytotoxic activities of essential oil from moringa oleifera seeds on HeLa, HepG2, MCF-7, CACO-2 and L929 cell lines. Asian Pac J Cancer Prev. 16:4671–4675. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Suphachai C: Antioxidant and anticancer activities of Moringa oleifera leaves. J Med Plants Res. 8:318–325. 2014. View Article : Google Scholar

13 

Potestà M, Minutolo A, Gismondi A, Canuti L, Kenzo M, Roglia V, Macchi F, Grelli S, Canini A, Colizzi V and Montesano C: Cytotoxic and apoptotic effects of different extracts of Moringa oleifera Lam on lymphoid and monocytoid cells. Exp Ther Med. 18:5–17. 2019.PubMed/NCBI

14 

Pirrò S, Matic I, Guidi A, Zanella L, Gismondi A, Cicconi R, Bernardini R, Colizzi V, Canini A, Mattei M and Galgani A: Identification of microRNAs and relative target genes in Moringa oleifera leaf and callus. Sci Rep. 9:151452019. View Article : Google Scholar : PubMed/NCBI

15 

Muangnoi C, Chingsuwanrote P, Praengamthanachoti P, Svasti S and Tuntipopipat S: Moringa oleifera pod inhibits inflammatory mediator production by lipopolysaccharide-stimulated RAW 264.7 murine macrophage cell lines. Inflammation. 35:445–455. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Budda S, Butryee C, Tuntipopipat S, Rungsipipat A, Wangnaithum S, Lee JS and Kupradinun P: Suppressive effects of Moringa oleifera Lam pod against mouse colon carcinogenesis induced by azoxymethane and dextran sodium sulfate. Asian Pac J Cancer Prev. 12:3221–3228. 2011.PubMed/NCBI

17 

Kraiphet S, Butryee C, Rungsipipat A, Budda S, Rattanapinyopitak K and Tuntipopipat S: Apoptosis induced by Moringa oleifera Lam. pod in mouse colon carcinoma model. Comp Clin Pathol. 27:21–30. 2018. View Article : Google Scholar

18 

Kosulwat V, Rojroongwasinkul N, Boonpraderm A, Viriyapanich T, Jitnarin N, Sornkaew N and Vanicchakul C: Food consumption data of Thailand. Bangkok: National Bureau of Agricultural Commodity and Food Standards, Ministry of Agriculture and Cooperatives; Bangkok, Thailand: 2006, (In Thai).

19 

Fahey JW: Moringa oleifera: A review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Part 1. Trees Life J. 1:52005.

20 

Raju J, Swamy MV, Cooma I, Patlolla JM, Pittman B, Reddy BS, Steele VE and Rao CV: Low doses of beta-carotene and lutein inhibit AOM-induced rat colonic ACF formation but high doses augment ACF incidence. Int J Cancer. 113:798–802. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Naganuma T, Shiogama K and Uchiumi T: The N-terminal regions of eukaryotic acidic phosphoproteins P1 and P2 are crucial for heterodimerization and assembly into the ribosomal GTPase-associated center. Genes Cells. 12:501–510. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Xu X, Xiong X and Sun Y: The role of ribosomal proteins in the regulation of cell proliferation, tumorigenesis, and genomic integrity. Sci China Life Sci. 59:656–672. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Zhang L, Zhou W, Velculescu VE, Kern SE, Hruban RH, Hamilton SR, Vogelstein B and Kinzler KW: Gene expression profiles in normal and cancer cells. Science. 276:1268–1272. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Loging WT and Reisman D: Elevated expression of ribosomal protein genes L37, RPP-1, and S2 in the presence of mutant p53. Cancer Epidemiol Biomarkers Prev. 8:1011–1016. 1999.PubMed/NCBI

25 

Artero-Castro A, Castellvi J, García A, Hernández J, Ramón y Cajal S and Lleonart ME: Expression of the ribosomal proteins Rplp0, Rplp1, and Rplp2 in gynecologic tumors. Hum Pathol. 42:194–203. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Artero-Castro A, Kondoh H, Fernández-Marcos PJ, Serrano M, Ramón y Cajal S and Lleonart ME: Rplp1 bypasses replicative senescence and contributes to transformation. Exp Cell Res. 315:1372–1383. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Perucho L, Artero-Castro A, Guerrero S, Ramón y Cajal S, LLeonart ME and Wang ZQ: RPLP1, a crucial ribosomal protein for embryonic development of the nervous system. PLoS One. 9:e999562014. View Article : Google Scholar : PubMed/NCBI

28 

Artero-Castro A, Perez-Alea M, Feliciano A, Leal JA, Genestar M, Castellvi J, Peg V, Ramón Y Cajal S and Lleonart ME: Disruption of the ribosomal P complex leads to stress-induced autophagy. Autophagy. 11:1499–1519. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Yan QJ, Asafo-Adjei PK, Arnold HM, Brown RE and Bauchwitz RP: A phenotypic and molecular characterization of the fmr1-tm1Cgr fragile X mouse. Genes Brain Behav. 3:337–359. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Bagni C, Tassone F, Neri G and Hagerman R: Fragile X syndrome: Causes, diagnosis, mechanisms, and therapeutics. J Clin Invest. 122:4314–4322. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Li Y, Tang Y, Ye L, Liu B, Liu K, Chen J and Xue Q: Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray. J Cancer Res Clin Oncol. 129:43–51. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Liu Y, Zhu X, Zhu J, Liao S, Tang Q, Liu K, Guan X, Zhang J and Feng Z: Identification of differential expression of genes in hepatocellular carcinoma by suppression subtractive hybridization combined cDNA microarray. Oncol Rep. 18:943–951. 2007.PubMed/NCBI

33 

Schultz-Pedersen S, Hasle H, Olsen JH and Friedrich U: Evidence of decreased risk of cancer in individuals with fragile X. Am J Med Genet. 103:226–230. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Lucá R, Averna M, Zalfa F, Vecchi M, Bianchi F, La Fata G, Del Nonno F, Nardacci R, Bianchi M, Nuciforo P, et al: The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation. EMBO Mol Med. 5:1523–1536. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Zalfa F, Panasiti V, Carotti S, Zingariello M, Perrone G, Sancillo L, Pacini L, Luciani F, Roberti V, D'Amico S, et al: The fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells. Cell Death Dis. 8:e31692017. View Article : Google Scholar : PubMed/NCBI

36 

Töhönen V, Osterlund C and Nordqvist K: Testatin: A cystatin-related gene expressed during early testis development. Proc Natl Acad Sci USA. 95:14208–14213. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Hasegawa K, Chuma S, Tada T, Sakurai T, Tamura M, Suemori H and Nakatsuji N: Testatin transgenic and knockout mice exhibit normal sex-differentiation. Biochem Biophys Res Commun. 341:369–375. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Eaves-Pyles T, Patel J, Arigi E, Cong Y, Cao A, Garg N, Dhiman M, Pyles RB, Arulanandam B, Miller AL, et al: Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis. Mol Med. 19:263–275. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Magister S and Kos J: Cystatins in immune system. J Cancer. 4:45–56. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Strojnik T, Zajc I, Bervar A, Zidanik B, Golouh R, Kos J, Dolenc V and Lah T: Cathepsin B and its inhibitor stefin A in brain tumors. Pflugers Arch. 439 (3 Suppl):R122S–R123S. 2000. View Article : Google Scholar

41 

Hong S, Choi I, Woo JM, Oh J, Kim T, Choi E, Kim TW, Jung YK, Kim DH, Sun CH, et al: Identification and integrative analysis of 28 novel genes specifically expressed and developmentally regulated in murine spermatogenic cells. J Biol Chem. 280:7685–7693. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Cassandri M, Smirnov A, Novelli F, Pitolli C, Agostini M, Malewicz M, Melino G and Raschellà G: Zinc-finger proteins in health and disease. Cell Death Discov. 3:170712017. View Article : Google Scholar : PubMed/NCBI

43 

Meruvu S, Hugendubler L and Mueller E: Regulation of adipocyte differentiation by the zinc finger protein ZNF638. J Biol Chem. 286:26516–26523. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Lu G and Wang Y: Functional diversity of mammalian type 2C protein phosphatase isoforms: New tales from an old family. Clin Exp Pharmacol Physiol. 35:107–112. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Sun C, Wang G, Wrighton KH, Lin H, Songyang Z, Feng XH and Lin X: Regulation of p27Kip1 phosphorylation and G1 cell cycle progression by protein phosphatase PPM1G. Am J Cancer Res. 6:2207–2220. 2016.PubMed/NCBI

46 

Khoronenkova SV, Dianova II, Ternette N, Kessler BM, Parsons JL and Dianov GL: ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Mol Cell. 45:801–813. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Foster WH, Langenbacher A, Gao C, Chen J and Wang Y: Nuclear phosphatase PPM1G in cellular survival and neural development. Dev Dyn. 242:1101–1109. 2013. View Article : Google Scholar : PubMed/NCBI

48 

McNamara RP, McCann JL, Gudipaty SA and D'Orso I: Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation. Cell Rep. 5:1256–1268. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Phannasil P, Roytrakul S, Phaonakrop N, Kupradinun P, Budda S, Butryee C, Akekawatchai C and Tuntipopipat S: Protein expression profiles that underpin the preventive and therapeutic potential of Moringa oleifera Lam against azoxymethane and dextran sodium sulfate‑induced mouse colon carcinogenesis. Oncol Lett 20: 1792-1802, 2020.
APA
Phannasil, P., Roytrakul, S., Phaonakrop, N., Kupradinun, P., Budda, S., Butryee, C. ... Tuntipopipat, S. (2020). Protein expression profiles that underpin the preventive and therapeutic potential of Moringa oleifera Lam against azoxymethane and dextran sodium sulfate‑induced mouse colon carcinogenesis. Oncology Letters, 20, 1792-1802. https://doi.org/10.3892/ol.2020.11730
MLA
Phannasil, P., Roytrakul, S., Phaonakrop, N., Kupradinun, P., Budda, S., Butryee, C., Akekawatchai, C., Tuntipopipat, S."Protein expression profiles that underpin the preventive and therapeutic potential of Moringa oleifera Lam against azoxymethane and dextran sodium sulfate‑induced mouse colon carcinogenesis". Oncology Letters 20.2 (2020): 1792-1802.
Chicago
Phannasil, P., Roytrakul, S., Phaonakrop, N., Kupradinun, P., Budda, S., Butryee, C., Akekawatchai, C., Tuntipopipat, S."Protein expression profiles that underpin the preventive and therapeutic potential of Moringa oleifera Lam against azoxymethane and dextran sodium sulfate‑induced mouse colon carcinogenesis". Oncology Letters 20, no. 2 (2020): 1792-1802. https://doi.org/10.3892/ol.2020.11730
Copy and paste a formatted citation
x
Spandidos Publications style
Phannasil P, Roytrakul S, Phaonakrop N, Kupradinun P, Budda S, Butryee C, Akekawatchai C and Tuntipopipat S: Protein expression profiles that underpin the preventive and therapeutic potential of Moringa oleifera Lam against azoxymethane and dextran sodium sulfate‑induced mouse colon carcinogenesis. Oncol Lett 20: 1792-1802, 2020.
APA
Phannasil, P., Roytrakul, S., Phaonakrop, N., Kupradinun, P., Budda, S., Butryee, C. ... Tuntipopipat, S. (2020). Protein expression profiles that underpin the preventive and therapeutic potential of Moringa oleifera Lam against azoxymethane and dextran sodium sulfate‑induced mouse colon carcinogenesis. Oncology Letters, 20, 1792-1802. https://doi.org/10.3892/ol.2020.11730
MLA
Phannasil, P., Roytrakul, S., Phaonakrop, N., Kupradinun, P., Budda, S., Butryee, C., Akekawatchai, C., Tuntipopipat, S."Protein expression profiles that underpin the preventive and therapeutic potential of Moringa oleifera Lam against azoxymethane and dextran sodium sulfate‑induced mouse colon carcinogenesis". Oncology Letters 20.2 (2020): 1792-1802.
Chicago
Phannasil, P., Roytrakul, S., Phaonakrop, N., Kupradinun, P., Budda, S., Butryee, C., Akekawatchai, C., Tuntipopipat, S."Protein expression profiles that underpin the preventive and therapeutic potential of Moringa oleifera Lam against azoxymethane and dextran sodium sulfate‑induced mouse colon carcinogenesis". Oncology Letters 20, no. 2 (2020): 1792-1802. https://doi.org/10.3892/ol.2020.11730
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