Open Access

Development and validation of a hypoxia‑related prognostic signature for breast cancer

  • Authors:
    • Jianxin Wang
    • Yuquan Wang
    • Ping Xing
    • Qianqi Liu
    • Cong Zhang
    • Yang Sui
    • Changjun Wu
  • View Affiliations

  • Published online on: June 16, 2020     https://doi.org/10.3892/ol.2020.11733
  • Pages: 1906-1914
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Hypoxia, an important component of the tumor microenvironment, plays a crucial role in the occurrence and progression of cancer. However, to the best of our knowledge, a systematic analysis of a hypoxia‑related prognostic signature for breast cancer is lacking and is urgently required. Therefore, in the present study, RNA‑seq data and clinical information were downloaded from The Cancer Genome Atlas (TCGA) and served as a discovery cohort. Cox proportional hazards regression analysis was performed to construct a 14‑gene prognostic signature (PFKL, P4HA2, GRHPR, SDC3, PPP1R15A, SIAH2, NDRG1, BTG1, TPD52, MAFF, ISG20, LALBA, ERRFI1 and VHL). The hypoxia‑related signature successfully predicted survival outcomes of the discovery cohort (P<0.001 for the TCGA dataset). Three independent Gene Expression Omnibus databases (GSE10886, GSE20685 and GSE96058) were used as validation cohorts to verify the value of the predictive signature (P=0.007 for GSE10886, P=0.021 for GSE20685, P<0.001 for GSE96058). In the present study, a robust predictive signature was developed for patients with breast cancer, and the findings revealed that the 14‑gene hypoxia‑related signature could serve as a potential prognostic biomarker for breast cancer.

Related Articles

Journal Cover

August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Wang, J., Wang, Y., Xing, P., Liu, Q., Zhang, C., Sui, Y., & Wu, C. (2020). Development and validation of a hypoxia‑related prognostic signature for breast cancer. Oncology Letters, 20, 1906-1914. https://doi.org/10.3892/ol.2020.11733
MLA
Wang, J., Wang, Y., Xing, P., Liu, Q., Zhang, C., Sui, Y., Wu, C."Development and validation of a hypoxia‑related prognostic signature for breast cancer". Oncology Letters 20.2 (2020): 1906-1914.
Chicago
Wang, J., Wang, Y., Xing, P., Liu, Q., Zhang, C., Sui, Y., Wu, C."Development and validation of a hypoxia‑related prognostic signature for breast cancer". Oncology Letters 20, no. 2 (2020): 1906-1914. https://doi.org/10.3892/ol.2020.11733