Open Access

Identification and validation of tumor microenvironment‑related genes of prognostic value in lung adenocarcinoma

  • Authors:
    • Jingyan Yuan
    • Bo Yuan
    • Lizhong Zeng
    • Boxuan Liu
    • Yang Chen
    • Xia Meng
    • Ruiying Sun
    • Xin Lv
    • Wei Wang
    • Shuanying Yang
  • View Affiliations

  • Published online on: June 16, 2020     https://doi.org/10.3892/ol.2020.11735
  • Pages: 1772-1780
  • Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Lung adenocarcinoma (LUAD) is a major subtype of non‑small cell lung cancer. Despite significant progress in its diagnosis and treatment, the mortality and morbidity rate of LUAD remains high worldwide. The aim of the present study was to perform a systematic investigation of the tumor microenvironment (TME) and identify TME‑related genes of prognostic value in patients with LUAD. Firstly, the immune scores and stromal scores of patients with LUAD from The Cancer Genome Atlas were calculated using the Estimation of STromal and Immune cells in MAlignant Tumors using Expression data algorithm, and a total of 281 prognostic TME‑related genes were identified. Subsequently, functional analysis and protein‑protein interaction network analysis revealed that these genes were mainly related to immune response, inflammatory response and chemotaxis. Finally, two independent LUAD cohorts from the Gene Expression Omnibus database were used to validate these genes, and 4 genes (GTPase IMAP family member 1, T‑cell surface glycoprotein CD1b, integrin alpha‑L and leukocyte surface antigen CD53) were identified, and downregulation of these genes was indicated to be associated with poor overall survival rate in patients with LUAD. In conclusion, a comprehensive analysis of TME was performed and 4 prognostic TME‑related genes in patients with LUAD were identified.

Related Articles

Journal Cover

August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Yuan, J., Yuan, B., Zeng, L., Liu, B., Chen, Y., Meng, X. ... Yang, S. (2020). Identification and validation of tumor microenvironment‑related genes of prognostic value in lung adenocarcinoma. Oncology Letters, 20, 1772-1780. https://doi.org/10.3892/ol.2020.11735
MLA
Yuan, J., Yuan, B., Zeng, L., Liu, B., Chen, Y., Meng, X., Sun, R., Lv, X., Wang, W., Yang, S."Identification and validation of tumor microenvironment‑related genes of prognostic value in lung adenocarcinoma". Oncology Letters 20.2 (2020): 1772-1780.
Chicago
Yuan, J., Yuan, B., Zeng, L., Liu, B., Chen, Y., Meng, X., Sun, R., Lv, X., Wang, W., Yang, S."Identification and validation of tumor microenvironment‑related genes of prognostic value in lung adenocarcinoma". Oncology Letters 20, no. 2 (2020): 1772-1780. https://doi.org/10.3892/ol.2020.11735