Open Access

Association between the methylation status of PCDH17 and the efficacy of neoadjuvant chemotherapy in triple-negative breast cancer

  • Authors:
    • De-Di Kong
    • Rong-Zhan Fu
    • Liang Li
    • Wei Wang
    • Shi-Bing Wang
  • View Affiliations

  • Published online on: June 16, 2020     https://doi.org/10.3892/ol.2020.11737
  • Pages: 1649-1656
  • Copyright: © Kong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to assess whether the methylation status of the protocadherin 17 gene (PCDH17) in triple‑negative breast cancer (TNBC) tissues was associated with the efficacy of neoadjuvant chemotherapy (NAC). The present study included 280 patients diagnosed with TNBC using core needle biopsy. Tumor pathological diagnosis was determined via hematoxylin and eosin staining. Immunohistochemical staining was used to determine estrogen receptor, progesterone receptor, human epidermal growth factor receptor‑2 and Ki‑67 status. PCDH17 methylation status was analyzed using methylation‑specific PCR. χ2 tests were performed to analyze differences between PCDH17 methylation status and TNBC clinicopathological features. Univariate and multivariate logistic regressions were used to analyze whether PCDH17 methylation status predicted a curative effect of NAC. The multivariate analysis included factors with P<0.2 from the univariate analysis and those that were clinically associated with NAC. A total of 228 patients were positive for PCDH17 methylation, while the remainder 52 were negative. Additionally, 107 patients achieved pathological complete response (pCR) after NAC. The pCR rate was 67.3% among the 52 patients negative for PCDH17 methylation and 31.6% among the 228 patients positive for PCDH17 methylation. Patients who were negative for PCDH17 methylation and had high Ki67 expression exhibited significantly higher pCR rates than their counterparts. The present results demonstrate that PCDH17 methylation status may predict the response to NAC in patients with TNBC. Therefore, this epigenetic characteristic may serve as an indicator of treatment efficacy.

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August-2020
Volume 20 Issue 2

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Spandidos Publications style
Kong D, Fu R, Li L, Wang W and Wang S: Association between the methylation status of PCDH17 and the efficacy of neoadjuvant chemotherapy in triple-negative breast cancer . Oncol Lett 20: 1649-1656, 2020
APA
Kong, D., Fu, R., Li, L., Wang, W., & Wang, S. (2020). Association between the methylation status of PCDH17 and the efficacy of neoadjuvant chemotherapy in triple-negative breast cancer . Oncology Letters, 20, 1649-1656. https://doi.org/10.3892/ol.2020.11737
MLA
Kong, D., Fu, R., Li, L., Wang, W., Wang, S."Association between the methylation status of PCDH17 and the efficacy of neoadjuvant chemotherapy in triple-negative breast cancer ". Oncology Letters 20.2 (2020): 1649-1656.
Chicago
Kong, D., Fu, R., Li, L., Wang, W., Wang, S."Association between the methylation status of PCDH17 and the efficacy of neoadjuvant chemotherapy in triple-negative breast cancer ". Oncology Letters 20, no. 2 (2020): 1649-1656. https://doi.org/10.3892/ol.2020.11737