Open Access

MKP‑1 overexpression is associated with chemoresistance in bladder cancer via the MAPK pathway

  • Authors:
    • Siyu Lei
    • Hong Xu
    • Naiwen Chen
    • Huan Pan
    • Wenhua Xie
    • Yi He
    • Jing Jin
  • View Affiliations

  • Published online on: June 16, 2020     https://doi.org/10.3892/ol.2020.11741
  • Pages: 1743-1751
  • Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mitogen activated protein kinase phosphatase‑1 (MKP‑1) has been revealed to be overexpressed in bladder cancer, particularly in non‑muscle invasive bladder cancer. MKP‑1 may also be associated with chemotherapy resistance. However, the underlying mechanism is yet to be elucidated. The current study investigated the expression of MKP‑1 by performing immunohistochemistry in surgically resected specimens obtained from primary and recurrent patients with bladder cancer. The results revealed that MKP‑1 expression increased in recurrent patients. Additionally, a 3D model of the human bladder cancer cell line, RT112, was established to determine the role of MKP‑1 in drug resistance. The results demonstrated that MKP‑1 overexpression protected bladder cancer cells against cell death. Contrarily, MKP‑1 knockdown was revealed to sensitize cells to death. In addition, the application of MAPK inhibitors effectively increased RT112 cell sensitivity to pirarubicin. In conclusion, the results of the current study indicated that MKP‑1 treatment resulted in bladder cancer cell chemoresistance via JNK, ERK and p38 pathways. MKP‑1 may also serve as a potential therapeutic target for chemoresistance in patients with bladder cancer.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Lei S, Xu H, Chen N, Pan H, Xie W, He Y and Jin J: MKP‑1 overexpression is associated with chemoresistance in bladder cancer via the MAPK pathway. Oncol Lett 20: 1743-1751, 2020
APA
Lei, S., Xu, H., Chen, N., Pan, H., Xie, W., He, Y., & Jin, J. (2020). MKP‑1 overexpression is associated with chemoresistance in bladder cancer via the MAPK pathway. Oncology Letters, 20, 1743-1751. https://doi.org/10.3892/ol.2020.11741
MLA
Lei, S., Xu, H., Chen, N., Pan, H., Xie, W., He, Y., Jin, J."MKP‑1 overexpression is associated with chemoresistance in bladder cancer via the MAPK pathway". Oncology Letters 20.2 (2020): 1743-1751.
Chicago
Lei, S., Xu, H., Chen, N., Pan, H., Xie, W., He, Y., Jin, J."MKP‑1 overexpression is associated with chemoresistance in bladder cancer via the MAPK pathway". Oncology Letters 20, no. 2 (2020): 1743-1751. https://doi.org/10.3892/ol.2020.11741