Open Access

SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx

  • Authors:
    • Satoshi Toyoma
    • Shinsuke Suzuki
    • Yohei Kawasaki
    • Takechiyo Yamada
  • View Affiliations

  • Published online on: June 17, 2020     https://doi.org/10.3892/ol.2020.11744
  • Pages: 1817-1823
  • Copyright: © Toyoma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hypopharyngeal squamous cell carcinoma (SCC) has a poor prognosis due to local invasion and metastasis. The chemokine receptor CXC chemokine receptor type 4 (CXCR4) and its ligand, stromal cell‑derived factor 1 (SDF‑1), play roles in tumor progression through unclear mechanisms. For the present study, we used a hypopharyngeal SCC cell line, FaDu, expressing CXCR4. We found that SDF‑1 promotes migration and invasion of the FaDu cells. In addition, AMD3100, a specific antagonist of CXCR4, inhibited the binding of SDF‑1 to CXCR4, resulting in a significant decrease in the FaDu cell migration induced by SDF‑1. Stimulation of CXCR4 with SDF‑1 induced an increase in the expression of CD147, a cell membrane protein; and this CD147 upregulation was abrogated by AMD3100. CD147 function‑blocking antibodies also abolished the SDF‑1‑induced FaDu invasiveness. Our results suggested that SDF‑1/CXCR4 mediate hypopharyngeal SCC cell migration and that CD147 is involved in the SDF‑1/CXCR4‑related tumor progression.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Toyoma, S., Suzuki, S., Kawasaki, Y., & Yamada, T. (2020). SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx. Oncology Letters, 20, 1817-1823. https://doi.org/10.3892/ol.2020.11744
MLA
Toyoma, S., Suzuki, S., Kawasaki, Y., Yamada, T."SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx". Oncology Letters 20.2 (2020): 1817-1823.
Chicago
Toyoma, S., Suzuki, S., Kawasaki, Y., Yamada, T."SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx". Oncology Letters 20, no. 2 (2020): 1817-1823. https://doi.org/10.3892/ol.2020.11744