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Article Open Access

SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx

  • Authors:
    • Satoshi Toyoma
    • Shinsuke Suzuki
    • Yohei Kawasaki
    • Takechiyo Yamada
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology and Head and Neck Surgery, Akita University Graduate School of Medicine, Akita 010‑8543, Japan
    Copyright: © Toyoma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1817-1823
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    Published online on: June 17, 2020
       https://doi.org/10.3892/ol.2020.11744
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Abstract

Hypopharyngeal squamous cell carcinoma (SCC) has a poor prognosis due to local invasion and metastasis. The chemokine receptor CXC chemokine receptor type 4 (CXCR4) and its ligand, stromal cell‑derived factor 1 (SDF‑1), play roles in tumor progression through unclear mechanisms. For the present study, we used a hypopharyngeal SCC cell line, FaDu, expressing CXCR4. We found that SDF‑1 promotes migration and invasion of the FaDu cells. In addition, AMD3100, a specific antagonist of CXCR4, inhibited the binding of SDF‑1 to CXCR4, resulting in a significant decrease in the FaDu cell migration induced by SDF‑1. Stimulation of CXCR4 with SDF‑1 induced an increase in the expression of CD147, a cell membrane protein; and this CD147 upregulation was abrogated by AMD3100. CD147 function‑blocking antibodies also abolished the SDF‑1‑induced FaDu invasiveness. Our results suggested that SDF‑1/CXCR4 mediate hypopharyngeal SCC cell migration and that CD147 is involved in the SDF‑1/CXCR4‑related tumor progression.
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1 

Carvalho AL, Pintos J, Schlecht NF, Oliveira BV, Fava AS, Curado MP, Kowalski LP and Franco EL: Predictive factors for diagnosis of advanced-stage squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 128:313–318. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Ho AS, Kim S, Tighiouart M, Gudino C, Mita A, Scher KS, Laury A, Prasad R, Shiao SL, Ali N, et al: Association of quantitativemetastatic lymph node burden with survival in hypopharyngeal and laryngeal cancer. JAMA Oncol. 4:985–989. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Zlotnik A and Yoshie O: Chemokines: A new classification system and their role in immunity. Immunity. 12:121–127. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Proudfoot AEI: Chemokine receptors: Multifaceted therapeutic targets. Nat Rev Immunol. 2:106–115. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Zhou Y, Larsen PH, Hao C and Yong VW: CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J Biol Chem. 277:49481–49487. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Burger JA and Kipps TJ: CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment. Blood. 107:1761–1767. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Balkwill F: Cancer and the chemokine network. Nat Rev Cancer. 4:540–550. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Scala S, Ottaiano A, Ascierto PA, Cavalli M, Simeone E, Giuliano P, Napolitano M, Franco R, Botti G and Castello G: Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma. Clin Cancer Res. 11:1835–1841. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Barbero S, Bonavia R, Bajetto A, Porcile C, Pirani P, Ravetti JL, Zona GL, Spaziante R, Florio T and Schettini G: Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt. Cancer Res. 63:1969–1974. 2003.PubMed/NCBI

10 

Müller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, et al: Involvement of chemokine receptors in breast cancer metastasis. Nature. 410:50–56. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Taichman RS, Cooper C, Keller ET, Pienta KJ, Taichman NS and McCauley LK: Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res. 62:1832–1837. 2002.PubMed/NCBI

12 

Jiang YP, Wu XH, Shi B, Wu WX and Yin GR: Expression of chemokine CXCL12 and its receptor CXCR4 in human epithelial ovarian cancer: An independent prognostic factor for tumor progression. Gynecol Oncol. 103:226–233. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Chen GS, Yu HS, Lan CC, Chow KC, Lin TY, Kok LF, Lu MP, Liu CH and Wu MT: CXC chemokine receptor CXCR4 expression enhances tumorigenesis and angiogenesis of basal cell carcinoma. Br J Dermatol. 154:910–918. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Tan CT, Chu CY, Lu YC, Chang CC, Lin BR, Wu HH, Liu HL, Cha ST, Prakash E, Ko JY and Kuo ML: CXCL12/CXCR4 promotes laryngeal and hypopharyngeal squamous cell carcinoma metastasis through MMP-13-dependent invasion via the ERK1/2/AP-1 pathway. Carcinogenesis. 29:1519–1527. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Samara GJ, Lawrence DM, Chiarelli CJ, Valentino MD, Lyubsky S, Zucker S and Vaday GG: CXCR4-mediated adhesion and MMP-9 secretion in head and neck squamous cell carcinoma. Cancer Lett. 214:231–241. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Hong JS, Pai HK, Hong KO, Kim MA, Kim JH, Lee JI, Hong SP and Hong SD: CXCR-4 knockdown by small interfering RNA inhibits cell proliferation and invasion of oral squamous cell carcinoma cells. J Oral Pathol Med. 38:214–219. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Rehman AO and Wang CY: CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex. Int J Oral Sci. 1:105–118. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Yu T, Wu Y, Helman JI, Wen Y, Wang C and Li L: CXCR4 Promotes oral squamous cell carcinoma migration and invasion through inducing expression of MMP-9 and MMP-13 via the ERK signaling pathway. Mol Cancer Res. 9:161–172. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Ishikawa T, Nakashiro KI, Hara S, Klosek SK, Li C, Shintani S and Hamakawa H: CXCR4 expression is associated with lymph-node metastasis of oral squamous cell carcinoma. Int J Oncol. 28:61–66. 2006.PubMed/NCBI

20 

Katayama A, Ogino T, Bandoh N, Nonaka S and Harabuchi Y: Expression of CXCR4 and its down-regulation by IFN-gamma in head and neck squamous cell carcinoma. Clin Cancer Res. 11:2937–2946. 2005. View Article : Google Scholar : PubMed/NCBI

21 

De-Colle C, Mönnich D, Welz S, Boeke S, Sipos B, Fend F, Mauz PS, Tinhofer I, Budach V, Jawad JA, et al: SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy. Clin Transl Radiat Oncol. 5:28–36. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Knopf A, Bahadori L, Fritsche K, Piontek G, Becker CC, Knolle P, Krüger A, Bier H and Li Y: Primary tumor-associated expression of CXCR4 predicts formation of local and systemic recurrency in head and neck squamous cell carcinoma. Oncotarget. 8:112739–112747. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Caudroy S, Polette M, Tournier JM, Burlet H, Toole B, Zucker S and Birembaut P: Expression of the extracellular matrix metalloproteinase inducer (EMMPRIN) and the matrix metalloproteinase-2 in bronchopulmonary and breast lesions. J Histochem Cytochem. 47:1575–1580. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Suzuki S, Sato M, Senoo H and Ishikawa K: Direct cell-cell interaction enhances pro-MMP-2 production and activation in co-culture of laryngeal cancer cells and fibroblasts: Involvement of EMMPRIN and MT1-MMP. Exp Cell Res. 293:259–266. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Hibino T, Sakaguchi M, Miyamoto S, Yamamoto M, Motoyama A, Hosoi J, Shimokata T, Ito T, Tsuboi R and Huh NH: S100A9 is a novel ligand of EMMPRIN that promotes melanoma metastasis. Cancer Res. 73:172–183. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Takahashi M, Suzuki S and Ishikawa K: Cyclophilin A-EMMPRIN interaction induces invasion of head and neck squamous cell carcinoma. Oncol Rep. 27:198–203. 2012.PubMed/NCBI

27 

Suzuki S, Honda K, Nanjo H, Iikawa N, Tsuji T, Kawasaki Y, Yamazaki K, Sato T, Saito H, Shiina K and Ishikawa K: CD147 expression correlates with lymph node metastasis inT1-T2 squamous cell carcinoma of the tongue. Oncol Lett. 14:4670–4676. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Shi WP, Ju D, Li H, Yuan L, Cui J, Luo D, Chen ZN and Bian H: CD147 promotes CXCL1 expression and modulates liver fibrogenesis. Int J Mol Sci. 19:11452018. View Article : Google Scholar

29 

Peng C, Zhang S, Lei L, Zhang X, Jia X, Luo Z, Huang X, Kuang Y, Zeng W, Su J and Chen X: Epidermal CD147 expression plays a key role in IL-22-induced psoriatic dermatitis. Sci Rep. 7:441722017. View Article : Google Scholar : PubMed/NCBI

30 

Bordador LC, Li X, Toole B, Chen B, Regezi J, Zardi L, Hu Y and Ramos DM: Expression of emmprin by oral squamous cell carcinoma. Int J Cancer. 85:347–352. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Koga K, Nabeshima K, Aoki M, Kawakami T, Hamasaki M, Toole BP, Nakayama J and Iwasaki H: Emmprin in epithelioid sarcoma: Expression in tumor cell membrane and stimulation of MMP-2 production in tumor-associated fibroblasts. Int J Cancer. 120:761–768. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Ishikawa T, Nakashiro KI, Klosek SK, Goda H, Hara S, Uchida D and Hamakawa H: Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma. Oncol Rep. 21:707–712. 2009.PubMed/NCBI

33 

Asakage T, Yokose T, Mukai K, Tsugane S, Tsubono Y, Asai M and Ebihara S: Tumor thickness predicts cervical metastasis in patients with stage I/II carcinoma of the tongue. Cancer. 82:1443–1448. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Koppikar P, Choi SH, Egloff AM, Cai Q, Suzuki S, Freilino M, Nozawa H, Thomas SM, Gooding WE, Siegfried JM and Grandis JR: Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma. Clin Cancer Res. 14:4284–4291. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Jung YH, Lee DY, Cha W, Kim BH, Sung MW, Kim KH and Ahn SH: Antitumor effect of CXCR4 antagonist AMD3100 on the tumorigenic cell line of BHP10-3 papillary thyroid cancer cells. Head Neck. 38:1479–1486. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Spano JP, Andre F, Morat L, Sabatier L, Besse B, Combadiere C, Deterre P, Martin A, Azorin J, Valeyre D, et al: Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: Pattern of expression and correlation with outcome. Ann Oncol. 15:613–617. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Koishi K, Yoshikawa R, Tsujimura T, Hashimoto-Tamaoki T, Kojima S, Yanagi H, Yamamura T and Fujiwara Y: Persistent CXCR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor prognosis in esophageal cancer. World J Gastroenterol. 12:7585–7590. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Zhou W, Guo S, Liu M, Burow ME and Wang G: Targeting CXCL12/CXCR4 axis in tumor immunotherapy. Curr Med Chem. 26:3026–3041. 2017. View Article : Google Scholar

39 

Jung MJ, Rho JK, Kim YM, Jung JE, Jin YB, Ko YG, Lee JS, Lee SJ, Lee JC and Park MJ: Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells. Oncogene. 32:209–221. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Es-Haghi M, Soltanian S and Dehghani H: Perspective: Cooperation of Nanog, NF-κΒ, and CXCR4 in a regulatory network for directed migration of cancer stem cells. Tumour Biol. 37:1559–1565. 2016. View Article : Google Scholar : PubMed/NCBI

41 

De-Colle C, Menegakis A, Mönnich D, Welz S, Boeke S, Sipos B, Fend F, Mauz PS, Tinhofer I, Budach V, et al: SDF-1/CXCR4 expression is an independent negative prognostic biomarker in patients with head and neck cancer after primary radiochemotherapy. Radiother Oncol. 126:125–131. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Wolff HA, Rolke D, Rave-Fränk M, Schirmer M, Eicheler W, Doerfler A, Hille A, Hess CF, Matthias C, Rödel RM and Christiansen H: Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck (SCCHN) cell lines. Radiat Environ Biophys. 50:145–154. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Zhu C, Pan Y, He B, Wang B, Xu Y, Qu L, Bao Q, Tian F and Wang S: Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells. Oncol Rep. 25:425–432. 2011.PubMed/NCBI

44 

Vu TH and Werb Z: Matrix metalloproteinases: Effectors of development and normal physiology. Genes Dev. 14:2123–2133. 2000. View Article : Google Scholar : PubMed/NCBI

45 

Rosenthal EL, Shreenivas S, Peters GE, Grizzle WE, Desmond R and Gladson CL: Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma. Laryngoscope. 113:1406–1410. 2003. View Article : Google Scholar : PubMed/NCBI

46 

Suzuki S, Toyoma S, Tsuji T, Kawasaki Y and Yamada T: CD147 mediates transforming growth factor-β1-induced epithelial-mesenchymal transition and cell invasion in squamous cell carcinoma of the tongue. Exp Ther Med. 17:2855–2860. 2019.PubMed/NCBI

47 

Landras A, de Moura CR, Jouenne F, Lebbe C, Menashi S and Mourah S: CD147 is a promising target of tumor progression and a prognostic biomarker. Cancers (Basel). 11:2019. View Article : Google Scholar : PubMed/NCBI

48 

Dean NR, Newman JR, Helman EE, Zhang W, Safavy S, Weeks DM, Cunningham M, Snyder LA, Tang Y, Yan L, et al: Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer. Clin Cancer Res. 15:4058–4065. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Vermorken JB, Herbst RS, Leon X, Amellal N and Baselga J: Overview of the efficacy of cetuximab in recurrent and/or metastatic squamous cell carcinoma of the head and neck in patients who previously failed platinum-based therapies. Cancer. 112:2710–2719. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Nozawa H, Howell G, Suzuki S, Zhang Q, Qi Y, Klein-Seetharaman J, Wells A, Grandis JR and Thomas SM: Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion. Clin Cancer Res. 14:4336–4344. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Suzuki S and Ishikawa K: Combined inhibition of EMMPRIN and epidermal growth factor receptor prevents the growth and migration of head and neck squamous cell carcinoma cells. Int J Oncol. 44:912–917. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Toyoma S, Suzuki S, Kawasaki Y and Yamada T: SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx. Oncol Lett 20: 1817-1823, 2020.
APA
Toyoma, S., Suzuki, S., Kawasaki, Y., & Yamada, T. (2020). SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx. Oncology Letters, 20, 1817-1823. https://doi.org/10.3892/ol.2020.11744
MLA
Toyoma, S., Suzuki, S., Kawasaki, Y., Yamada, T."SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx". Oncology Letters 20.2 (2020): 1817-1823.
Chicago
Toyoma, S., Suzuki, S., Kawasaki, Y., Yamada, T."SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx". Oncology Letters 20, no. 2 (2020): 1817-1823. https://doi.org/10.3892/ol.2020.11744
Copy and paste a formatted citation
x
Spandidos Publications style
Toyoma S, Suzuki S, Kawasaki Y and Yamada T: SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx. Oncol Lett 20: 1817-1823, 2020.
APA
Toyoma, S., Suzuki, S., Kawasaki, Y., & Yamada, T. (2020). SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx. Oncology Letters, 20, 1817-1823. https://doi.org/10.3892/ol.2020.11744
MLA
Toyoma, S., Suzuki, S., Kawasaki, Y., Yamada, T."SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx". Oncology Letters 20.2 (2020): 1817-1823.
Chicago
Toyoma, S., Suzuki, S., Kawasaki, Y., Yamada, T."SDF‑1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx". Oncology Letters 20, no. 2 (2020): 1817-1823. https://doi.org/10.3892/ol.2020.11744
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