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Prognostic value of immune cell infiltration in bladder cancer: A gene expression‑based study

  • Authors:
    • Yao Wang
    • Hong‑Jun Ba
    • Zi‑Chuan Liu
    • Xu‑Bin Deng
    • Min Zhou
  • View Affiliations / Copyright

    Affiliations: Medical Oncology Department, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China, Pediatric Cardiology Department, Heart Center, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1677-1684
    |
    Published online on: June 17, 2020
       https://doi.org/10.3892/ol.2020.11750
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Abstract

The present study aimed to analyse the relationship between tumour‑infiltrating immune cells (TIICs) and the prognosis of bladder cancer (BC). In the present study, an established computational method (CIBERSORT) was used to analyse the gene expression profile of BC from 409 patients to infer the number of infiltrating immune cells among 22 immune cell subsets. The relationship between each cell type and overall survival (OS) was further analysed. Single‑sample GSEA and ESTIMATE algorithms were performed to evaluate the composition of immune microenvironment in each immune cluster. A significant difference in immune cell infiltration between BC and bladder tissue was observed. Increased natural killer and CD8+ T cell infiltration was associated with longer OS, whereas a higher percentage of M0 macrophages among the total immune cells was associated with shorter OS. The number of M0 macrophages increased with increasing BC stage, whereas the percentage of activated memory CD4+ and CD8+ T cells decreased. Patients with BC were divided into three subgroups by hierarchical cluster analysis of immune cells, and each cluster was associated with distinct survival and immune characteristics. The data indicated differences in the cellular composition of TIICs in patients with BC. Moreover, these TIICs were shown to be potential drug targets and reliable prognostic indicators.
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1 

Malats N and Real FX: Epidemiology of bladder cancer. Hematol Oncol Clin North Am. 29:177–189. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Kaufman DS, Shipley WU and Feldman AS: Bladder cancer. Lancet. 374:239–249. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Hurst C, Rosenberg J and Knowles M: SnapShot: Bladder cancer. Cancer Cell. 34:350 e12018. View Article : Google Scholar

5 

Stetler-Stevenson WG: The tumor microenvironment: The connective tissue/tumor cell/host organ system that modulates tumor progression. Connect Tissue Res. 56:343–344. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Fridman WH, Pages F, Sautes-Fridman C and Galon J: The immune contexture in human tumours: Impact on clinical outcome. Nat Rev Cancer. 12:298–306. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Zitvogel L, Galluzzi L, Smyth MJ and Kroemer G: Mechanism of action of conventional and targeted anticancer therapies: Reinstating immunosurveillance. Immunity. 39:74–88. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Branchoux S, Bellera C, Italiano A, Rustand D, Gaudin AF and Rondeau V: Immune-checkpoint inhibitors and candidate surrogate endpoints for overall survival across tumour types a systematic literature review. Crit Rev Oncol Hematol. 137:35–42. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Ottaviano M, De Placido S and Ascierto PA: Recent success and limitations of immune checkpoint inhibitors for cancer: A lesson from melanoma. Virchows Arch. 474:421–432. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, et al: Safety and activity of anti-PDL1 antibody in patients with advanced cancer. N Engl J Med. 366:2455–2465. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Gnjatic S, Bronte V, Brunet LR, Butler MO, Disis ML, Galon J, Hakansson LG, Hanks BA, Karanikas V, Khleif SN, et al: Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy. J Immunother Cancer. 5:442017. View Article : Google Scholar : PubMed/NCBI

12 

Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, et al: PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 515:568–571. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Masson-Lecomte A, Rava M, Real FX, Hartmann A, Allory Y and Malats N: Inflammatory biomarkers and bladder cancer prognosis: A systematic review. Eur Urol. 66:1078–1091. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Kawai K, Miyazaki J, Joraku A, Nishiyama H and Akaza H: Bacillus Calmette-Guerin (BCG) immunotherapy for bladder cancer: Current understanding and perspectives on engineered BCG vaccine. Cancer Sci. 104:22–27. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Kim J: Immune checkpoint blockade therapy for bladder cancer treatment. Investig Clin Urol. 57 (Suppl 1):S98–S105. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Siska PJ, Johnpulle RAN, Zhou A, Bordeaux J, Kim JY, Dabbas B, Dakappagari N, Rathmell JC, Rathmell WK, Morgans AK, et al: Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling. Oncoimmunology. 6:e13055352017. View Article : Google Scholar : PubMed/NCBI

17 

Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, Hoang CD, Diehn M and Alizadeh AA: Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 12:453–457. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Liu X, Wu S, Yang Y, Zhao M, Zhu G and Hou Z: The prognostic landscape of tumor-infiltrating immune cell and immunomodulators in lung cancer. Biomed Pharmacother. 95:55–61. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Xiong Y, Wang K, Zhou H, Peng L, You W and Fu Z: Profiles of immune infiltration in colorectal cancer and their clinical significant: A gene expression-based study. Cancer Med. 7:4496–4508. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Ali HR, Chlon L, Pharoah PD, Markowetz F and Caldas C: Patterns of immune infiltration in breast cancer and their clinical implications: A gene-expression-based retrospective study. PLoS Med. 13:e10021942016. View Article : Google Scholar : PubMed/NCBI

21 

He Y, Jiang Z, Chen C and Wang X: Classification of triple-negative breast cancers based on Immunogenomic profiling. J Exp Clin Cancer Res. 37:3272018. View Article : Google Scholar : PubMed/NCBI

22 

Hänzelmann S, Castelo R and Guinney J: GSVA: Gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 14:72013. View Article : Google Scholar : PubMed/NCBI

23 

Yoshihara K, Shahmoradgoli M, Martínez E Vegesna R, Kim H, Torres-Garcia W, Treviño V, Shen H, Laird PW, Levine DA, et al: Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 4:26122013. View Article : Google Scholar : PubMed/NCBI

24 

Rooney MS, Shukla SA, Wu CJ, Getz G and Hacohen N: Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell. 160:48–61. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Pathria P, Louis TL and Varner JA: Targeting tumor-associated macrophages in cancer. Trends Immunol. 40:310–327. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Chanmee T, Ontong P, Konno K and Itano N: Tumor-associated macrophages as major players in the tumor microenvironment. Cancers (Basel). 6:1670–1690. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Binnemars-Postma K, Storm G and Prakash J: Nanomedicine strategies to target tumor-associated macrophages. Int J Mol Sci. 18:9792017. View Article : Google Scholar

28 

Ascierto PA, Capone M, Urba WJ, Bifulco CB, Botti G, Lugli A, Marincola FM, Ciliberto G, Galon J and Fox BA: The additional facet of immunoscore: Immunoprofiling as a possible predictive tool for cancer treatment. J Transl Med. 11:542013. View Article : Google Scholar : PubMed/NCBI

29 

Lipponen PK, Eskelinen MJ, Jauhiainen K, Harju E and Terho R: Tumour infiltrating lymphocytes as an independent prognostic factor in transitional cell bladder cancer. Eur J Cancer 29A. 69–75. 1992.

30 

Horn T, Laus J, Seitz AK, Maurer T, Schmid SC, Wolf P, Haller B, Winkler M, Retz M, Nawroth R, et al: The prognostic effect of tumour-infiltrating lymphocytic subpopulations in bladder cancer. World J Urol. 34:181–187. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Wang B, Pan W, Yang M, Yang W, He W, Chen X, Bi J, Jiang N, Huang J and Lin T: Programmed death ligand-1 is associated with tumor infiltrating lymphocytes and poorer survival in urothelial cell carcinoma of the bladder. Cancer Sci. 10:489–498. 2019. View Article : Google Scholar

32 

Baras AS, Drake C, Liu JJ, Gandhi N, Kates M, Hoque MO, Meeker A, Hahn N, Taube JM, Schoenberg MP, et al: The ratio of CD8 to Treg tumor-infiltrating lymphocytes is associated with response to cisplatin-based neoadjuvant chemotherapy in patients with muscle invasive urothelial carcinoma of the bladder. Oncoimmunology. 5:e11344122016. View Article : Google Scholar : PubMed/NCBI

33 

Pahl J and Cerwenka A: Tricking the balance: NK cells in anti-cancer immunity. Immunobiology. 222:11–20. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Crouse J, Xu HC, Lang PA and Oxenius A: NK cells regulating T cell responses: Mechanisms and outcome. Trends Immunol. 1:49–58. 2015. View Article : Google Scholar

35 

Jaigirdar SA and MacLeod MK: Development and function of protective and pathologic memory CD4 T cells. Front Immunol. 6:4562015. View Article : Google Scholar : PubMed/NCBI

36 

Tran Janco JM, Lamichhane P, Karyampudi L and Knutson KL: Tumor-infiltrating dendritic cells in cancer pathogenesis. J Immunol. 194:2985–2991. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Darvin P, Toor SM, Sasidharan Nair V and Elkord E: Immune checkpoint inhibitors: Recent progress and potential biomarkers. Exp Mol Med. 50:1–11. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Ba HJ, Liu ZC, Deng XB and Zhou M: Prognostic value of immune cell infiltration in bladder cancer: A gene expression‑based study. Oncol Lett 20: 1677-1684, 2020.
APA
Wang, Y., Ba, H., Liu, Z., Deng, X., & Zhou, M. (2020). Prognostic value of immune cell infiltration in bladder cancer: A gene expression‑based study. Oncology Letters, 20, 1677-1684. https://doi.org/10.3892/ol.2020.11750
MLA
Wang, Y., Ba, H., Liu, Z., Deng, X., Zhou, M."Prognostic value of immune cell infiltration in bladder cancer: A gene expression‑based study". Oncology Letters 20.2 (2020): 1677-1684.
Chicago
Wang, Y., Ba, H., Liu, Z., Deng, X., Zhou, M."Prognostic value of immune cell infiltration in bladder cancer: A gene expression‑based study". Oncology Letters 20, no. 2 (2020): 1677-1684. https://doi.org/10.3892/ol.2020.11750
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Ba HJ, Liu ZC, Deng XB and Zhou M: Prognostic value of immune cell infiltration in bladder cancer: A gene expression‑based study. Oncol Lett 20: 1677-1684, 2020.
APA
Wang, Y., Ba, H., Liu, Z., Deng, X., & Zhou, M. (2020). Prognostic value of immune cell infiltration in bladder cancer: A gene expression‑based study. Oncology Letters, 20, 1677-1684. https://doi.org/10.3892/ol.2020.11750
MLA
Wang, Y., Ba, H., Liu, Z., Deng, X., Zhou, M."Prognostic value of immune cell infiltration in bladder cancer: A gene expression‑based study". Oncology Letters 20.2 (2020): 1677-1684.
Chicago
Wang, Y., Ba, H., Liu, Z., Deng, X., Zhou, M."Prognostic value of immune cell infiltration in bladder cancer: A gene expression‑based study". Oncology Letters 20, no. 2 (2020): 1677-1684. https://doi.org/10.3892/ol.2020.11750
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