Open Access

Correlation of changes in serum S100β, NSE and inflammatory factor levels with MMSE and MoCA in intracranial tumor patients with cognitive impairment

  • Authors:
    • Danfeng Yu
    • Boyi Liu
    • Guoquan Jiang
    • Shiwen Pei
    • Huan Pan
  • View Affiliations

  • Published online on: June 17, 2020     https://doi.org/10.3892/ol.2020.11751
  • Pages: 1968-1972
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Changes in serum neuron‑specific enolase (NSE) level, S100β protein concentration and inflammatory factor levels and their correlations with cognitive impairment Mini‑Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores in intracranial tumor patients with cognitive impairment were explored. Seventy patients diagnosed with intracranial tumor based on clinical symptoms and computed tomography (CT) images were selected and divided into non‑cognitive impairment group (MoCA score ≥26 points, n=44) and cognitive impairment group (MoCA score <26 points, n=26) in accordance with the comprehensive cognitive function evaluation scores. Next, the serum NSE level, S100β protein concentration and inflammatory factor levels were detected, and their relationships with MMSE and MoCA scores were analyzed via Pearson's correlation analysis. The MoCA and MMSE scores in non‑cognitive impairment group were higher than those in cognitive impairment group (P<0.05). NSE and S100β levels were higher in non‑cognitive impairment group compared with cognitive impairment group (P<0.05). In addition, the levels of interleukin‑6 (IL‑6), IL‑8 and tumor necrosis factor‑α (TNF‑α) were higher in cognitive impairment group than those in non‑cognitive impairment group (P<0.05). The levels of patient's serum NSE, S100β protein and inflammatory factors were negatively related to MMSE and MoCA scores (P<0.05). The changes in serum NSE, S100β protein and inflammatory factor levels in patients with cognitive impairment can reflect the severity of the disease to a certain extent and are directly related to cognitive impairment. Accurate and comprehensive assessment of cognitive function of patients and early development of effective and targeted cognitive interventions are of certain clinical practical value for the improvement of prognosis.

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August-2020
Volume 20 Issue 2

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APA
Yu, D., Liu, B., Jiang, G., Pei, S., & Pan, H. (2020). Correlation of changes in serum S100β, NSE and inflammatory factor levels with MMSE and MoCA in intracranial tumor patients with cognitive impairment . Oncology Letters, 20, 1968-1972. https://doi.org/10.3892/ol.2020.11751
MLA
Yu, D., Liu, B., Jiang, G., Pei, S., Pan, H."Correlation of changes in serum S100β, NSE and inflammatory factor levels with MMSE and MoCA in intracranial tumor patients with cognitive impairment ". Oncology Letters 20.2 (2020): 1968-1972.
Chicago
Yu, D., Liu, B., Jiang, G., Pei, S., Pan, H."Correlation of changes in serum S100β, NSE and inflammatory factor levels with MMSE and MoCA in intracranial tumor patients with cognitive impairment ". Oncology Letters 20, no. 2 (2020): 1968-1972. https://doi.org/10.3892/ol.2020.11751