Open Access

Prognostic potential of lncRNA RHPN1-AS1 in glioma

  • Authors:
    • Yong Wu
    • Wuting Wei
    • Linjun Tang
    • Liangwei Wang
  • View Affiliations

  • Published online on: June 25, 2020     https://doi.org/10.3892/ol.2020.11773
  • Pages: 2442-2446
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Expression level of long non-coding RNA (lncRNA) RHPN1-AS1 in glioma tissues was detected to determine potential risk factors influencing prognosis of glioma. This study aimed to clarify the molecular mechanisms underlying tumorigenesis of glioma and thus to improve therapeutic efficacy of glioma. RHPN1-AS1 levels in glioma tissues (n=105) and normal brain tissues (n=105) were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The relationship between RHPN1-AS1 level and pathological indicators of glioma patients was analyzed. Glioma patients were followed up for 5 years. Overall survival (OS) and relapse-free survival (RFS) in glioma patients were tested by Kaplan-Meier and log‑rank method. Potential factors influencing prognosis of glioma were analyzed by Cox regression model. RHPN1-AS1 was upregulated in glioma tissues. Its level was correlated to histological grade, Karnofsky (KPS) score and postoperative recurrence of glioma patients, rather than sex, age, pathological and tumor size. Glioma patients expressing high level of RHPN1-AS1 suffered worse OS and RFS than those with low level. Advanced histological grade, KPS score <80 and high level of RHPN1-AS1 were considered to be risk factors influencing postoperative prognosis of glioma. High level of RHPN1-AS1 is an independent risk factor for poor prognosis of glioma, which may be utilized as a prognostic hallmark.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wu Y, Wei W, Tang L and Wang L: Prognostic potential of lncRNA RHPN1-AS1 in glioma. Oncol Lett 20: 2442-2446, 2020
APA
Wu, Y., Wei, W., Tang, L., & Wang, L. (2020). Prognostic potential of lncRNA RHPN1-AS1 in glioma. Oncology Letters, 20, 2442-2446. https://doi.org/10.3892/ol.2020.11773
MLA
Wu, Y., Wei, W., Tang, L., Wang, L."Prognostic potential of lncRNA RHPN1-AS1 in glioma". Oncology Letters 20.3 (2020): 2442-2446.
Chicago
Wu, Y., Wei, W., Tang, L., Wang, L."Prognostic potential of lncRNA RHPN1-AS1 in glioma". Oncology Letters 20, no. 3 (2020): 2442-2446. https://doi.org/10.3892/ol.2020.11773