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Prognostic potential of lncRNA RHPN1-AS1 in glioma

  • Authors:
    • Yong Wu
    • Wuting Wei
    • Linjun Tang
    • Liangwei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Second People's Hospital of Wuhu, Wuhu, Anhui 241000, P.R. China, Department of Neurosurgery, Jinling Hospital, Nanjing Medical University, Nanjing, Jiangsu 210002, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2442-2446
    |
    Published online on: June 25, 2020
       https://doi.org/10.3892/ol.2020.11773
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Abstract

Expression level of long non-coding RNA (lncRNA) RHPN1-AS1 in glioma tissues was detected to determine potential risk factors influencing prognosis of glioma. This study aimed to clarify the molecular mechanisms underlying tumorigenesis of glioma and thus to improve therapeutic efficacy of glioma. RHPN1-AS1 levels in glioma tissues (n=105) and normal brain tissues (n=105) were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The relationship between RHPN1-AS1 level and pathological indicators of glioma patients was analyzed. Glioma patients were followed up for 5 years. Overall survival (OS) and relapse-free survival (RFS) in glioma patients were tested by Kaplan-Meier and log‑rank method. Potential factors influencing prognosis of glioma were analyzed by Cox regression model. RHPN1-AS1 was upregulated in glioma tissues. Its level was correlated to histological grade, Karnofsky (KPS) score and postoperative recurrence of glioma patients, rather than sex, age, pathological and tumor size. Glioma patients expressing high level of RHPN1-AS1 suffered worse OS and RFS than those with low level. Advanced histological grade, KPS score <80 and high level of RHPN1-AS1 were considered to be risk factors influencing postoperative prognosis of glioma. High level of RHPN1-AS1 is an independent risk factor for poor prognosis of glioma, which may be utilized as a prognostic hallmark.
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1 

Sathornsumetee S and Rich JN: New treatment strategies for malignant gliomas. Expert Rev Anticancer Ther. 6:1087–1104. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Liu L, Zhang Y, Zhu K, Song L, Tao M, Huang P and Pan Y: Resveratrol inhibits glioma cell growth via targeting LRIG1. J BUON. 23:403–409. 2018.PubMed/NCBI

3 

Wang Y and Lan Q: Long non-coding RNA AFAP1-AS1 accelerates invasion and predicts poor prognosis of glioma. Eur Rev Med Pharmacol Sci. 22:5223–5229. 2018.PubMed/NCBI

4 

Batista PJ and Chang HY: Long noncoding RNAs: Cellular address codes in development and disease. Cell. 152:1298–1307. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Reid IR: Short-term and long-term effects of osteoporosis therapies. Nat Rev Endocrinol. 11:418–428. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Han L, Zhang K, Shi Z, Zhang J, Zhu J, Zhu S, Zhang A, Jia Z, Wang G, Yu S, et al: LncRNA profile of glioblastoma reveals the potential role of lncRNAs in contributing to glioblastoma pathogenesis. Int J Oncol. 40:2004–2012. 2012.PubMed/NCBI

7 

Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK and DePinho RA: Malignant glioma: Genetics and biology of a grave matter. Genes Dev. 15:1311–1333. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Mo XB, Wu LF, Lu X, Zhu XW, Xia W, Wang L, He P, Bing PF, Zhang YH, Deng FY, et al: Detection of lncRNA-mRNA interaction modules by integrating eQTL with weighted gene co-expression network analysis. Funct Integr Genomics. 19:217–225. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Li X, Zhang X, Yang C, Cui S, Shen Q and Xu S: The lncRNA RHPN1-AS1 downregulation promotes gefitinib resistance by targeting miR-299-3p/TNFSF12 pathway in NSCLC. Cell Cycle. 17:1772–1783. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Lu L, Yu X, Zhang L, Ding X, Pan H, Wen X, Xu S, Xing Y, Fan J, Ge S, et al: The long non-coding RNA RHPN1-AS1 promotes uveal melanoma progression. Int J Mol Sci. 18:2262017. View Article : Google Scholar

11 

Xu C, Ping Y, Zhao H, Ning S, Xia P, Wang W, Wan L, Li J, Zhang L, Yu L and Xiao Y: LncNetP, a systematical lncRNA prioritization approach based on ceRNA and disease phenotype association assumptions. Oncotarget. 8:114603–114612. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Duan H, Li X, Chen Y, Wang Y and Li Z: LncRNA RHPN1-AS1 promoted cell proliferation, invasion and migration in cervical cancer via the modulation of miR-299-3p/FGF2 axis. Life Sci. 239:1168562019. View Article : Google Scholar : PubMed/NCBI

13 

Fen H, Hongmin Z, Wei W, Chao Y, Yang Y, Bei L and Zhihua S: RHPN1-AS1 drives the progression of hepatocellular carcinoma via regulating miR-596/IGF2BP2 axis. Curr Pharm Des. 25:4630–4640. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Cui P, Su J, Li Q, Xu G and Zhu N: LncRNA RHPN1-AS1 targeting miR-625/REG3A promotes cell proliferation and invasion of glioma cells. OncoTargets Ther. 12:7911–7921. 2019. View Article : Google Scholar

15 

Wesseling P and Capper D: WHO 2016 Classification of gliomas. Neuropathol Appl Neurobiol. 44:139–150. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Dimberg A: The glioblastoma vasculature as a target for cancer therapy. Biochem Soc Trans. 42:1647–1652. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Wapinski O and Chang HY: Long noncoding RNAs and human disease. Trends Cell Biol. 21:354–361. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Yang Z, Lu Y, Xu Q, Tang B, Park CK and Chen X: HULC and H19 played different roles in overall and disease-free survival from hepatocellular carcinoma after curative hepatectomy: A preliminary analysis from gene expression omnibus. Dis Markers. 2015:1910292015. View Article : Google Scholar : PubMed/NCBI

19 

Li J, Meng H, Bai Y and Wang K: Regulation of lncRNA and its role in cancer metastasis. Oncol Res. 23:205–217. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Li C, Lei B, Huang S, Zheng M, Liu Z, Li Z and Deng Y: H19 derived microRNA-675 regulates cell proliferation and migration through CDK6 in glioma. Am J Transl Res. 7:1747–1764. 2015.PubMed/NCBI

21 

Wang Y, Wang Y, Li J, Zhang Y, Yin H and Han B: CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling. Cancer Lett. 367:122–128. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Zhang Y, Sun Y, Peng R, Liu H, He W, Zhang L, Peng H and Zhang Z: The long noncoding RNA 150Rik promotes mesangial cell proliferation via miR-451/IGF1R/p38 MAPK signaling in diabetic nephropathy. Cell Physiol Biochem. 51:1410–1428. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Dong X, Fang Z, Yu M, Zhang L, Xiao R, Li X, Pan G and Liu J: Knockdown of long noncoding RNA HOXA-AS2 suppresses chemoresistance of acute myeloid leukemia via the miR-520c-3p/S100A4 Axis. Cell Physiol Biochem. 51:886–896. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Powers AS: Adult neurogenesis in mammals and nonmammals. Commentary on Kempermann G (2012): New neurons for ‘survival of the fittest’. Nat Rev Neurosci 13:727-736. Brain Behav Evol. 81:206–208. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Weng J, Tu M, Wang P, Zhou X, Wang C, Wan X, Zhou Z, Wang L, Zheng X, Li J, et al: Corrigendum to ‘Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts’ [Biomed. Pharmacother. 115 (2019) 108889]. Biomed Pharmacother. 118:1090852019. View Article : Google Scholar : PubMed/NCBI

26 

Wei N, Wei H and Zhang H: Long non-coding RNA ZEB1-AS1 promotes glioma cell proliferation, migration and invasion through regulating miR-577. Eur Rev Med Pharmacol Sci. 22:3085–3093. 2018.PubMed/NCBI

27 

Zheng S, Lv P, Su J, Miao K, Xu H and Li M: Silencing of the long non-coding RNA RHPN1-AS1 suppresses the epithelial-to-mesenchymal transition and inhibits breast cancer progression. Am J Transl Res. 11:3505–3517. 2019.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Wei W, Tang L and Wang L: Prognostic potential of lncRNA RHPN1-AS1 in glioma. Oncol Lett 20: 2442-2446, 2020.
APA
Wu, Y., Wei, W., Tang, L., & Wang, L. (2020). Prognostic potential of lncRNA RHPN1-AS1 in glioma. Oncology Letters, 20, 2442-2446. https://doi.org/10.3892/ol.2020.11773
MLA
Wu, Y., Wei, W., Tang, L., Wang, L."Prognostic potential of lncRNA RHPN1-AS1 in glioma". Oncology Letters 20.3 (2020): 2442-2446.
Chicago
Wu, Y., Wei, W., Tang, L., Wang, L."Prognostic potential of lncRNA RHPN1-AS1 in glioma". Oncology Letters 20, no. 3 (2020): 2442-2446. https://doi.org/10.3892/ol.2020.11773
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Y, Wei W, Tang L and Wang L: Prognostic potential of lncRNA RHPN1-AS1 in glioma. Oncol Lett 20: 2442-2446, 2020.
APA
Wu, Y., Wei, W., Tang, L., & Wang, L. (2020). Prognostic potential of lncRNA RHPN1-AS1 in glioma. Oncology Letters, 20, 2442-2446. https://doi.org/10.3892/ol.2020.11773
MLA
Wu, Y., Wei, W., Tang, L., Wang, L."Prognostic potential of lncRNA RHPN1-AS1 in glioma". Oncology Letters 20.3 (2020): 2442-2446.
Chicago
Wu, Y., Wei, W., Tang, L., Wang, L."Prognostic potential of lncRNA RHPN1-AS1 in glioma". Oncology Letters 20, no. 3 (2020): 2442-2446. https://doi.org/10.3892/ol.2020.11773
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