Open Access

Immune disorder in endometrial cancer: Immunosuppressive microenvironment, mechanisms of immune evasion and immunotherapy (Review)

  • Authors:
    • Lei Zhan
    • Xiaojing Liu
    • Jing Zhang
    • Yunxia Cao
    • Bing Wei
  • View Affiliations

  • Published online on: June 25, 2020     https://doi.org/10.3892/ol.2020.11774
  • Pages: 2075-2090
  • Copyright: © Zhan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Immunotherapy is an emerging clinical approach that has gained traction over the past decade as a novel treatment option for lung cancer and melanoma. Notably, researchers have made marked improvements in the treatment of endometrial cancer (EC), and potential immune responses have been identified in patients with EC, thereby offering the possibility of exploring immunotherapy for EC. Nevertheless, various needs remain unmet, and immunotherapy applications in EC have yielded limited success, as only a minority of patients exhibited a clinical response. Therefore, further understanding of immune dysfunction associated with EC is still required. The present review describes recent findings regarding the immunosuppressive microenvironment of EC, with emphasis on immune evasion mechanisms and immunotherapy in EC.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhan L, Liu X, Zhang J, Cao Y and Wei B: Immune disorder in endometrial cancer: Immunosuppressive microenvironment, mechanisms of immune evasion and immunotherapy (Review). Oncol Lett 20: 2075-2090, 2020
APA
Zhan, L., Liu, X., Zhang, J., Cao, Y., & Wei, B. (2020). Immune disorder in endometrial cancer: Immunosuppressive microenvironment, mechanisms of immune evasion and immunotherapy (Review). Oncology Letters, 20, 2075-2090. https://doi.org/10.3892/ol.2020.11774
MLA
Zhan, L., Liu, X., Zhang, J., Cao, Y., Wei, B."Immune disorder in endometrial cancer: Immunosuppressive microenvironment, mechanisms of immune evasion and immunotherapy (Review)". Oncology Letters 20.3 (2020): 2075-2090.
Chicago
Zhan, L., Liu, X., Zhang, J., Cao, Y., Wei, B."Immune disorder in endometrial cancer: Immunosuppressive microenvironment, mechanisms of immune evasion and immunotherapy (Review)". Oncology Letters 20, no. 3 (2020): 2075-2090. https://doi.org/10.3892/ol.2020.11774