Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Potential five‑mRNA signature model for the prediction of prognosis in patients with papillary thyroid carcinoma

  • Authors:
    • Lin‑Kun Zhong
    • Xiao‑Xiong Gan
    • Xing‑Yan Deng
    • Fei Shen
    • Jian‑Hua Feng
    • Wen‑Song Cai
    • Qiong‑Yao Liu
    • Jian‑Hang Miao
    • Bing‑Xing Zheng
    • Bo Xu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510630, P.R. China, Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China, Department of Oncology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China, Department of General Surgery, Zhongshan City People's Hospital Affiliated to Sun Yat‑sen University, Zhongshan, Guangdong 528403, P.R. China
    Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2302-2310
    |
    Published online on: June 26, 2020
       https://doi.org/10.3892/ol.2020.11781
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Although the mortality rate of papillary thyroid carcinoma (PTC) is relatively low, the recurrence rates of PTC remain high. The high recurrence rates are related to the difficulties in treatment. Gene expression profiles has provided novel insights into potential therapeutic targets and molecular biomarkers of PTC. The aim of the present study was to identify mRNA signatures which may categorize PTCs into high‑and low‑risk subgroups and aid with the predictions for prognoses. The mRNA expression profiles of PTC and normal thyroid tissue samples were obtained from The Cancer Genome Atlas (TCGA) database. Differentially expressed mRNAs were identified using the ‘EdgeR’ software package. Gene signatures associated with the overall survival of PTC were selected, and enrichment analysis was performed to explore the biological pathways and functions of the prognostic mRNAs using the Database for Visualization, Annotation and Integration Discovery. A signature model was established to investigate a specific and robust risk stratification for PTC. A total of 1,085 differentially expressed mRNAs were identified between the PTC and normal thyroid tissue samples. Among them, 361 mRNAs were associated with overall survival (P<0.05). A 5‑mRNA prognostic signature for PTC (ADRA1B, RIPPLY3, PCOLCE, TEKT1 and SALL3) was identified to classify the patients into high‑and low‑risk subgroups. These prognostic mRNAs were enriched in Gene Ontology terms such as ‘calcium ion binding’, ‘enzyme inhibitor activity’, ‘carbohydrate binding’, ‘transcriptional activator activity’, ‘RNA polymerase II core promoter proximal region sequence‑specific binding’ and ‘glutathione transferase activity’, and Kyoto Encyclopedia of Genes and Genomes signaling pathways such as ‘pertussis’, ‘ascorbate and aldarate metabolism’, ‘systemic lupus erythematosus’, ‘drug metabolism‑cytochrome P450 and ‘complement and coagulation cascades’. The 5‑mRNA signature model may be useful during consultations with patients with PTC to improve the prediction of their prognosis. In addition, the prognostic signature identified in the present study may reveal novel therapeutic targets for patients with PTC.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Howlader N, Noone AM, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, et al: SEER Cancer Statistics Review, 1975–2016. Bethesda, MD: National Cancer Institute; based on November 2018 SEER data submission, posted to the SEER web site. April. 2019

3 

Alzahrani AS and Xing M: Impact of Iymph node metastases identified on central neck dissection (CND) on the recurrence of papillary thyroid cancer: Potential role of BRAFV600E mutation in defining CND. Endocr Relat Cancer. 20:13–22. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Carcangiu ML, Zampi G, Pupi A, Castagnoli A and Rosai J: Papillary carcinoma of the thyroid. A clinicopathologic study of 241 cases treated at the University of Florence, Italy. Cancer. 55:805–828. 1985. View Article : Google Scholar : PubMed/NCBI

5 

Albores-Saavedra J and Wu J: The many faces and mimics of papillary thyroid carcinoma. Endocr Pathol. 17:1–18. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Shen X, Liu R and Xing M: A six-genotype genetic prognostic model for papillary thyroid cancer. Endocr Relat Cancer. 24:41–52. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : View Article : Google Scholar : PubMed/NCBI

8 

Omry-Orbach G: Risk stratification in differentiated thyroid cancer: An ongoing process. Rambam Maimonides Med J. 7:e00032016. View Article : Google Scholar

9 

Luster M, Clarke SE, Dietlein M, Lassmann M, Lind P, Oyen WJ, Tennvall J and Bombardieri E; European Association of Nuclear Medicine (EANM), : Guidelines for radioiodine therapy of differentiated thyroid cancer. Eur J Nucl Med Mol Imaging. 35:1941–1959. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Feng G, Ma HM, Huang HB, Li YW, Zhang P, Huang JJ, Cheng L and Li GR: Overexpression of COL5A1 promotes tumor progression and metastasis and correlates with poor survival of patients with clear cell renal cell carcinoma. Cancer Manag Res. 11:1263–1274. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Tschirdewahn S, Panic A, Püllen L, Harke NN, Hadaschik B, Riesz P, Horváth A, Szalontai J, Nyirády P, Baba HA, et al: Circulating and tissue IMP3 levels are correlated with poor survival in renal cell carcinoma. Int J Cancer. 145:531–539. 2019.PubMed/NCBI

12 

Gąsior-Perczak D, Kowalik A, Walczyk A, Siołek M, Gruszczyński K, Pałyga I, Mikina E, Trybek T, Kopczyński J, Mężyk R, et al: Coexisting germline CHEK2 and somatic BRAFV600E mutations in papillary thyroid cancer and their association with clinicopathological features and disease course. Cancers (Basel). 11:17442019. View Article : Google Scholar

13 

Cancer Genome Atlas Research Network, . Integrated genomic characterization of papillary thyroid carcinoma. Cell. 159:676–690. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Zhao Y, Yu T, Chen L, Xie D, Wang F, Fu L, Cheng C, Li Y, Zhu X and Miao G: A germline CHEK2 mutation in a family with papillary thyroid cancer. Thyroid. 30:924–930. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Tomczak K, Czerwińska P and Wiznerowicz M: The Cancer Genome Atlas (TCGA): An immeasurable source of knowledge. Contemp Oncol (Pozn). 19:A68–A77. 2015.PubMed/NCBI

16 

R Core Team: R: A language and environment for statistical computing. Computing. 1:12–21. 2015.

17 

Gong Y, Zou B, Chen J, Ding L, Li P, Chen J, Chen J, Zhang B and Li J: Potential Five-MicroRNA signature model for the prediction of prognosis in patients with Wilms tumor. Med Sci Monit. 25:5435–5444. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Fan Q and Liu B: Identification of a RNA-Seq based 8-long non-coding RNA signature predicting survival in esophageal cancer. Med Sci Monit. 22:5163–5172. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Tian S, Meng G and Zhang W: A six-mRNA prognostic model to predict survival in head and neck squamous cell carcinoma. Cancer Manag Res. 11:131–142. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Tang J, Kong D, Cui Q, Wang K, Zhang D, Yuan Q, Liao X, Gong Y and Wu G: Bioinformatic analysis and identification of potential prognostic microRNAs and mRNAs in thyroid cancer. PeerJ. 6:e46742018. View Article : Google Scholar : PubMed/NCBI

22 

Prislei S, Martinelli E, Zannoni GF, Petrillo M, Filippetti F, Mariani M, Mozzetti S, Raspaglio G, Scambia G and Ferlini C: Role and prognostic significance of the epithelial-mesenchymal transition factor ZEB2 in ovarian cancer. Oncotarget. 6:18966–18979. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Zhan HX, Xu JW, Wang L, Wu D, Zhang GY and Hu SY: FoxQ1 is a novel molecular target for pancreatic cancer and is associated with poor prognosis. Curr Mol Med. 15:469–477. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Lu H, Chen S, You Z, Xie C, Huang S and Hu X: PFKFB4 negatively regulated the expression of histone acetyltransferase GCN5 to mediate the tumorigenesis of thyroid cancer. Dev Growth Differ. 62:129–138. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Huang L, Cai Y, Luo Y, Xiong D, Hou Z, Lv J, Zeng F, Yang Y and Cheng X: JAZF1 suppresses papillary thyroid carcinoma cell proliferation and facilitates apoptosis via regulating TAK1/NF-κB pathways. Onco Targets Ther. 12:10501–10514. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Yu ST, Zhong Q, Chen RH, Han P, Li SB, Zhang H, Yuan L, Xia TL, Zeng MS and Huang XM: CRLF1 promotes malignant phenotypes of papillary thyroid carcinoma by activating the MAPK/ERK and PI3K/AKT pathways. Cell Death Dis. 9:3712018. View Article : Google Scholar : PubMed/NCBI

27 

Vecchio G, Parascandolo A, Allocca C, Ugolini C, Basolo F, Moracci M, Strazzulli A, Cobucci-Ponzano B, Laukkanen MO, Castellone MD and Tsuchida N: Human a-L-fucosidase-1 attenuates the invasive properties of thyroid cancer. Oncotarget. 8:27075–27092. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Bertoni APS, Bracco PA, de Campos RP, Lutz BS, Assis-Brasil BM, Meyer ELS, Saffi J, Braganhol E, Furlanetto TW and Wink MR: Activity of ecto-5′-nucleotidase (NT5E/CD73) is increased in papillary thyroid carcinoma and its expression is associated with metastatic lymph nodes. Mol Cell Endocrinol. 479:54–60. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Jendrzejewski JP, Liyanarachchi S, Nagy R, Senter L, Wakely PE, Thomas A, Nabhan F, He H, Li W, Sworczak K, et al: Papillary thyroid carcinoma: Association between germline DNA variant markers and clinical parameters. Thyroid. 26:1276–1284. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Siołek M, Cybulski C, Gąsior-Perczak D, Kowalik A, Kozak-Klonowska B, Kowalska A, Chłopek M, Kluźniak W, Wokołorczyk D, Pałyga I, et al: CHEK2 mutations and the risk of papillary thyroid cancer. Int J Cancer. 137:548–552. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Wójcicka A, Czetwertyńska M, Świerniak M, Długosińska J, Maciąg M, Czajka A, Dymecka K, Kubiak A, Kot A, Płoski R, et al: Variants in the ATM-CHEK2-BRCA1 axis determine genetic predisposition and clinical presentation of papillary thyroid carcinoma. Genes Chromosomes Cancer. 53:516–523. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Stein L, Rothschild J, Luce J, Cowell JK, Thomas G, Bogdanova TI, Tronko MD and Hawthorn L: Copy number and gene expression alterations in radiation-induced papillary thyroid carcinoma from chernobyl pediatric patients. Thyroid. 20:475–487. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Chang Z, Cai C, Han D, Gao Y, Li Q, Feng L, Zhang W, Zheng J, Jin J, Zhang H and Wei Q: Anoctamin5 regulates cell migration and invasion in thyroid cancer. Int J Oncol. 51:1311–1319. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Tenbaum SP, Juenemann S, Schlitt T, Bernal J, Renkawitz R, Muñoz A and Baniahmad A: Alien/CSN2 gene expression is regulated by thyroid hormone in rat brain. Dev Biol. 254:149–160. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Zhu S, Zhou HY, Deng SC, Deng SJ, He C, Li X, Chen JY, Jin Y, Hu ZL, Wang F, et al: ASIC1 and ASIC3 contribute to acidity-induced EMT of pancreatic cancer through activating Ca2+/RhoA pathway. Cell Death Dis. 8:e28062017. View Article : Google Scholar : PubMed/NCBI

36 

Ceder R, Haig Y, Merne M, Hansson A, Zheng X, Roberg K, Nees M, Iljin K, Bloor BK, Morgan PR, et al: Differentiation-promoting culture of competent and noncompetent keratinocytes identifies biomarkers for head and neck cancer. Am J Pathol. 180:457–472. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Zhang DL, Qu LW, Ma L, Zhou YC, Wang GZ, Zhao XC, Zhang C, Zhang YF, Wang M, Zhang MY, et al: Genome-wide identification of transcription factors that are critical to non-small cell lung cancer. Cancer Lett. 434:132–143. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Cui T, Yang L, Ma Y, Petersen I and Chen Y: Desmocollin 3 has a tumor suppressive activity through inhibition of AKT pathway in colorectal cancer. Exp Cell Res. 378:124–130. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Liang L, Zeng JH, Qin XG, Chen JQ, Luo DZ and Chen G: Distinguishable prognostic signatures of left- and right-sided colon cancer: A study based on sequencing data. Cell Physiol Biochem. 48:475–490. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Lan Y, Xiao X, Luo Y, He Z and Song X: FEZF1 is an independent predictive factor for recurrence and promotes cell proliferation and migration in cervical cancer. J Cancer. 9:3929–3938. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Burotto M, Chiou VL, Lee JM and Kohn EC: The MAPK pathway across different malignancies: A new perspective. Cancer. 120:3446–3456. 2015. View Article : Google Scholar

42 

Nakagawa H, Hirata Y, Takeda K, Hayakawa Y, Sato T, Kinoshita H, Sakamoto K, Nakata W, Hikiba Y, Omata M, et al: Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase. Hepatology. 54:185–195. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Li S, Yin Y and Yu H: Genetic expression profile-based screening of genes and pathways associated with papillary thyroid carcinoma. Oncol Lett. 16:5723–5732. 2018.PubMed/NCBI

44 

Chen S, Fan X, Gu H, Zhang L and Zhao W: Competing endogenous RNA regulatory network in papillary thyroid carcinoma. Mol Med Rep. 18:695–704. 2018.PubMed/NCBI

45 

Puxeddu E and Moretti S: Clinical prognosis in BRAF-mutated PTC. Arq Bras Endocrinol Metabol. 51:736–747. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Wu M, Yuan H, Li X, Liao Q and Liu Z: Identification of a five-gene signature and establishment of a prognostic nomogram to predict progression-free interval of papillary thyroid carcinoma. Front Endocrinol (Lausanne). 10:7902019. View Article : Google Scholar : PubMed/NCBI

47 

Cao R, Wu Q, Li Q, Yao M and Zhou H: A 3-mRNA-based prognostic signature of survival in oral squamous cell carcinoma. PeerJ. 7:e73602019. View Article : Google Scholar : PubMed/NCBI

48 

Cai J, Tong Y, Huang L, Xia L, Guo H, Wu H, Kong X and Xia Q: Identification and validation of a potent multi-mRNA signature for the prediction of early relapse in hepatocellular carcinoma. Carcinogenesis. 40:840–852. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Xie X, Wang J, Shi D, Zou Y, Xiong Z, Li X, Zhou J, Tang H and Xie X: Identification of a 4-mRNA metastasis-related prognostic signature for patients with breast cancer. J Cell Mol Med. 23:1439–1447. 2019. View Article : Google Scholar : PubMed/NCBI

50 

Guo W, Chen X, Zhu L and Wang Q: A six-mRNA signature model for the prognosis of head and neck squamous cell carcinoma. Oncotarget. 8:94528–94538. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Chuang MK, Chiu YC, Chou WC, Hou HA, Tseng MH, Kuo YY, Chen Y, Chuang EY and Tien HF: An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype. Oncotarget. 6:39098–39110. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Bao ZS, Li MY, Wang JY, Zhang CB, Wang HJ, Yan W, Liu YW, Zhang W, Chen L and Jiang T: Prognostic value of a nine-gene signature in glioma patients based on mRNA expression profiling. CNS Neurosci Ther. 20:112–118. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhong LK, Gan XX, Deng XY, Shen F, Feng JH, Cai WS, Liu QY, Miao JH, Zheng BX, Xu B, Xu B, et al: Potential five‑mRNA signature model for the prediction of prognosis in patients with papillary thyroid carcinoma. Oncol Lett 20: 2302-2310, 2020.
APA
Zhong, L., Gan, X., Deng, X., Shen, F., Feng, J., Cai, W. ... Xu, B. (2020). Potential five‑mRNA signature model for the prediction of prognosis in patients with papillary thyroid carcinoma. Oncology Letters, 20, 2302-2310. https://doi.org/10.3892/ol.2020.11781
MLA
Zhong, L., Gan, X., Deng, X., Shen, F., Feng, J., Cai, W., Liu, Q., Miao, J., Zheng, B., Xu, B."Potential five‑mRNA signature model for the prediction of prognosis in patients with papillary thyroid carcinoma". Oncology Letters 20.3 (2020): 2302-2310.
Chicago
Zhong, L., Gan, X., Deng, X., Shen, F., Feng, J., Cai, W., Liu, Q., Miao, J., Zheng, B., Xu, B."Potential five‑mRNA signature model for the prediction of prognosis in patients with papillary thyroid carcinoma". Oncology Letters 20, no. 3 (2020): 2302-2310. https://doi.org/10.3892/ol.2020.11781
Copy and paste a formatted citation
x
Spandidos Publications style
Zhong LK, Gan XX, Deng XY, Shen F, Feng JH, Cai WS, Liu QY, Miao JH, Zheng BX, Xu B, Xu B, et al: Potential five‑mRNA signature model for the prediction of prognosis in patients with papillary thyroid carcinoma. Oncol Lett 20: 2302-2310, 2020.
APA
Zhong, L., Gan, X., Deng, X., Shen, F., Feng, J., Cai, W. ... Xu, B. (2020). Potential five‑mRNA signature model for the prediction of prognosis in patients with papillary thyroid carcinoma. Oncology Letters, 20, 2302-2310. https://doi.org/10.3892/ol.2020.11781
MLA
Zhong, L., Gan, X., Deng, X., Shen, F., Feng, J., Cai, W., Liu, Q., Miao, J., Zheng, B., Xu, B."Potential five‑mRNA signature model for the prediction of prognosis in patients with papillary thyroid carcinoma". Oncology Letters 20.3 (2020): 2302-2310.
Chicago
Zhong, L., Gan, X., Deng, X., Shen, F., Feng, J., Cai, W., Liu, Q., Miao, J., Zheng, B., Xu, B."Potential five‑mRNA signature model for the prediction of prognosis in patients with papillary thyroid carcinoma". Oncology Letters 20, no. 3 (2020): 2302-2310. https://doi.org/10.3892/ol.2020.11781
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team