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DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection

  • Authors:
    • Tomohiro Sugiyama
    • Moriya Iwaizumi
    • Masanao Kaneko
    • Shinya Tani
    • Mihoko Yamade
    • Yasushi Hamaya
    • Takahisa Furuta
    • Hiroaki Miyajima
    • Satoshi Osawa
    • Satoshi Baba
    • Masato Maekawa
    • Ken Sugimoto
  • View Affiliations / Copyright

    Affiliations: First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan, Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan, Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan, Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan, Department of Diagnostic Pathology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan
    Copyright: © Sugiyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2435-2441
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    Published online on: July 1, 2020
       https://doi.org/10.3892/ol.2020.11799
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Abstract

The frequency of deficient mismatch repair (dMMR) or microsatellite instability‑high colorectal cancer (CRC) is estimated to be ~15% of all patients with CRC; however, the patients reported are limited to surgical cases, and the frequency of patients exhibiting stage 0 disease is not considered, despite the currently increasing use of endoscopic techniques to cure a number of these patients. In the present study, the DNA MMR status for stage 0 patients with CRC treated using endoscopic submucosal dissection or endoscopic mucosal resection was analyzed via immunohistochemical staining of four types of proteins, namely MutL homolog 1 (MLH1), MutS homolog 2 (MSH2), MSH6 and PMS1 homolog 2 MMR system component, in adenocarcinoma specimens. Notably, none of the endoscopically resected specimens exhibited dMMR among the 41 patients diagnosed with stage 0 CRC. Since tumors harboring dMMR progress more rapidly than tumors with chromosomal instability, the present results highlight the importance of tumor resection during very early phases that exist before the promoter region of MLH1 becomes hypermethylated, resulting in a loss of DNA MMR function.
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Copy and paste a formatted citation
Spandidos Publications style
Sugiyama T, Iwaizumi M, Kaneko M, Tani S, Yamade M, Hamaya Y, Furuta T, Miyajima H, Osawa S, Baba S, Baba S, et al: DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection. Oncol Lett 20: 2435-2441, 2020.
APA
Sugiyama, T., Iwaizumi, M., Kaneko, M., Tani, S., Yamade, M., Hamaya, Y. ... Sugimoto, K. (2020). DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection. Oncology Letters, 20, 2435-2441. https://doi.org/10.3892/ol.2020.11799
MLA
Sugiyama, T., Iwaizumi, M., Kaneko, M., Tani, S., Yamade, M., Hamaya, Y., Furuta, T., Miyajima, H., Osawa, S., Baba, S., Maekawa, M., Sugimoto, K."DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection". Oncology Letters 20.3 (2020): 2435-2441.
Chicago
Sugiyama, T., Iwaizumi, M., Kaneko, M., Tani, S., Yamade, M., Hamaya, Y., Furuta, T., Miyajima, H., Osawa, S., Baba, S., Maekawa, M., Sugimoto, K."DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection". Oncology Letters 20, no. 3 (2020): 2435-2441. https://doi.org/10.3892/ol.2020.11799
Copy and paste a formatted citation
x
Spandidos Publications style
Sugiyama T, Iwaizumi M, Kaneko M, Tani S, Yamade M, Hamaya Y, Furuta T, Miyajima H, Osawa S, Baba S, Baba S, et al: DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection. Oncol Lett 20: 2435-2441, 2020.
APA
Sugiyama, T., Iwaizumi, M., Kaneko, M., Tani, S., Yamade, M., Hamaya, Y. ... Sugimoto, K. (2020). DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection. Oncology Letters, 20, 2435-2441. https://doi.org/10.3892/ol.2020.11799
MLA
Sugiyama, T., Iwaizumi, M., Kaneko, M., Tani, S., Yamade, M., Hamaya, Y., Furuta, T., Miyajima, H., Osawa, S., Baba, S., Maekawa, M., Sugimoto, K."DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection". Oncology Letters 20.3 (2020): 2435-2441.
Chicago
Sugiyama, T., Iwaizumi, M., Kaneko, M., Tani, S., Yamade, M., Hamaya, Y., Furuta, T., Miyajima, H., Osawa, S., Baba, S., Maekawa, M., Sugimoto, K."DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection". Oncology Letters 20, no. 3 (2020): 2435-2441. https://doi.org/10.3892/ol.2020.11799
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