Long non‑coding RNA GAS5 in human cancer (Review)

  • Authors:
    • Xiaoyan Yang
    • Zhizhong Xie
    • Xiaoyong Lei
    • Runliang Gan
  • View Affiliations

  • Published online on: July 3, 2020     https://doi.org/10.3892/ol.2020.11809
  • Pages: 2587-2594
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs (lncRNAs) constitute a group of >200‑nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth. The present study focused on growth arrest‑specific transcript 5 (GAS5), a well‑known lncRNA that acts as a tumor suppressor but is suppressed in multiple types of cancer, including mammary carcinoma, prostate cancer, colorectal cancer, gastric cancer, melanoma, esophageal squamous cell carcinoma, lung cancer, ovarian cancer, cervical cancer, gliomas, osteosarcoma, pancreatic cancer, bladder cancer, kidney cancer, papillary thyroid carcinoma, neuroblastoma, endometrial cancer and liver cancer. Notably, GAS5 is overexpressed in liver cancer, potentially functioning as an oncogene. In the present study, the diagnostic and therapeutic roles of GAS5 in different tumors were reviewed, with a summary of the potential clinical application of the lncRNA, which may help identify novel study directions for GAS5.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yang X, Xie Z, Lei X and Gan R: Long non‑coding RNA GAS5 in human cancer (Review). Oncol Lett 20: 2587-2594, 2020
APA
Yang, X., Xie, Z., Lei, X., & Gan, R. (2020). Long non‑coding RNA GAS5 in human cancer (Review). Oncology Letters, 20, 2587-2594. https://doi.org/10.3892/ol.2020.11809
MLA
Yang, X., Xie, Z., Lei, X., Gan, R."Long non‑coding RNA GAS5 in human cancer (Review)". Oncology Letters 20.3 (2020): 2587-2594.
Chicago
Yang, X., Xie, Z., Lei, X., Gan, R."Long non‑coding RNA GAS5 in human cancer (Review)". Oncology Letters 20, no. 3 (2020): 2587-2594. https://doi.org/10.3892/ol.2020.11809