MicroRNA‑125b reduces glucose uptake in papillary thyroid carcinoma cells

Zhang,Guowu; Zhou,Sihai; Yang,Quan; Liu,Fang

doi:10.3892/ol.2020.11832

MicroRNA‑125b reduces glucose uptake in papillary thyroid carcinoma cells

Authors:
- Guowu Zhang
- Sihai Zhou
- Quan Yang
- Fang Liu
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Affiliations: Department of General Surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, P.R. China, Department of Radiology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, P.R. China
Published online on: July 8, 2020 https://doi.org/10.3892/ol.2020.11832
Pages: 2806-2810
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous studies have shown that microRNA (miR)‑125b plays important roles in several human cancer types. The aim of the present study was to analyze the potential roles of miR‑125b in papillary thyroid carcinoma (PTC). It was found that miR‑125b was downregulated in PTC and its expression was affected by clinical stages. Glucose transporter 1 (GLUT1) was upregulated in PTC and was negatively correlated with miR‑125b. In PTC cells, overexpression of miR‑125b suppressed glucose uptake and downregulated GLUT1. Furthermore, GLUT1 overexpression reduced the effects of miR‑125b overexpression on glucose uptake. Moreover, miR‑125b overexpression suppressed PTC cell proliferation. GLUT1 overexpression promoted the proliferation of PTC cells and reduced the effects of miR‑125b overexpression on cancer cell proliferation. Overall, miR‑125b decreased glucose uptake in PTC cells by downregulating GLUT1.

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