Open Access

Atonal bHLH transcription factor 1 is an important factor for maintaining the balance of cell proliferation and differentiation in tumorigenesis (Review)

  • Authors:
    • Ying Fu
    • Sha‑Sha Yuan
    • Li‑Jie Zhang
    • Zhi‑Li Ji
    • Xiao‑Jiang Quan
  • View Affiliations

  • Published online on: July 8, 2020     https://doi.org/10.3892/ol.2020.11833
  • Pages: 2595-2605
  • Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Establishing the link between cellular processes and oncogenesis may aid the elucidation of targeted and effective therapies against tumor cell proliferation and metastasis. Previous studies have investigated the mechanisms involved in maintaining the balance between cell proliferation, differentiation and migration. There is increased interest in determining the conditions that allow cancer stem cells to differentiate as well as the identification of molecules that may serve as novel drug targets. Furthermore, the study of various genes, including transcription factors, which serve a crucial role in cellular processes, may present a promising direction for future therapy. The present review described the role of the transcription factor atonal bHLH transcription factor 1 (ATOH1) in signaling pathways in tumorigenesis, particularly in cerebellar tumor medulloblastoma and colorectal cancer, where ATOH1 serves as an oncogene or tumor suppressor, respectively. Additionally, the present review summarized the associated therapeutic interventions for these two types of tumors and discussed novel clinical targets and approaches.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Fu Y, Yuan SS, Zhang LJ, Ji ZL and Quan XJ: Atonal bHLH transcription factor 1 is an important factor for maintaining the balance of cell proliferation and differentiation in tumorigenesis (Review). Oncol Lett 20: 2595-2605, 2020
APA
Fu, Y., Yuan, S., Zhang, L., Ji, Z., & Quan, X. (2020). Atonal bHLH transcription factor 1 is an important factor for maintaining the balance of cell proliferation and differentiation in tumorigenesis (Review). Oncology Letters, 20, 2595-2605. https://doi.org/10.3892/ol.2020.11833
MLA
Fu, Y., Yuan, S., Zhang, L., Ji, Z., Quan, X."Atonal bHLH transcription factor 1 is an important factor for maintaining the balance of cell proliferation and differentiation in tumorigenesis (Review)". Oncology Letters 20.3 (2020): 2595-2605.
Chicago
Fu, Y., Yuan, S., Zhang, L., Ji, Z., Quan, X."Atonal bHLH transcription factor 1 is an important factor for maintaining the balance of cell proliferation and differentiation in tumorigenesis (Review)". Oncology Letters 20, no. 3 (2020): 2595-2605. https://doi.org/10.3892/ol.2020.11833