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Article

The combination of orlistat, lonidamine and 6‑diazo‑5‑oxo‑L‑norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells

  • Authors:
    • Alejandro Schcolnik‑Cabrera
    • Alma Chavez‑Blanco
    • Guadalupe Dominguez‑Gomez
    • Mandy Juarez
    • Donna Lai
    • Sheng Hua
    • Armando R. Tovar
    • Jose Diaz‑Chavez
    • Alfonso Duenas‑Gonzalez
  • View Affiliations / Copyright

    Affiliations: Division of Basic Research, National Cancer Institute, Mexico City 14080, Mexico, Molecular Biology Facility, University of Sydney, Sydney, NSW 2006, Australia, Nutrition Physiology Department, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City 14080, Mexico
  • Pages: 3053-3060
    |
    Published online on: July 9, 2020
       https://doi.org/10.3892/ol.2020.11838
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Abstract

Cancer upregulates glycolysis, glutaminolysis and lipogenesis, and induces a catabolic state in patients. The concurrent inhibition of both tumor anabolism and host catabolism, and the energetic consequences of such an approach, have not previously been fully investigated. In the present study, CT26.WT murine colon cancer cells were treated with the combination of anti‑anabolic drugs orlistat, lonidamine and 6‑diazo‑5‑oxo‑L‑norleucine (DON; OLD scheme), which are inhibitors of the de novo synthesis of fatty acids, glycolysis and glutaminolysis, respectively. In addition, the effects of OLD scheme sumplemented with the combination of anti‑catabolic compounds, namely growth hormone, insulin and indomethacin (GII scheme), were also evaluated. The effects of the compounds used in combination on CT26.WT cell viability, clonogenicity and energetic metabolism were assessed in vitro. The results demonstrated that the anti‑anabolic approach reduced cell viability, clonogenicity and cell cycle progression, and increased apoptosis. These effects were associated with decreased oxidative phosphorylation, glycolysis and fuel flexibility. Furthermore, the anti‑catabolic scheme, alone or supplemented with anti‑anabolic compounds, did not favor tumor growth. These findings indicated that the simultaneous pharmacological inhibition of tumor anabolism and host catabolism exhibits antitumor effects that should be further evaluated.
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1 

Mathupala SP, Ko YH and Pedersen PL: Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene. 25:4777–4786. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Erickson JW and Cerione RA: Glutaminase: A hot spot for regulation of cancer cell metabolism? Oncotarget. 1:734–740. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Menendez JA and Lupu R: Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer. 7:763–777. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Guttridge DC, Mayo MW, Madrid LV, Wang CY and Baldwin AS Jr: NF-kappaB-induced loss of MyoD messenger RNA: Possible role in muscle decay and cachexia. Science. 289:2363–2366. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Tayek JA and Brasel JA: Failure of anabolism in malnourished cancer patients receiving growth hormone: A clinical research center study. J Clin Endocrinol Metab. 80:2082–2087. 1995. View Article : Google Scholar : PubMed/NCBI

6 

DeBerardinis RJ and Cheng T: Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene. 29:313–324. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Tijerina AJ: The biochemical basis of metabolism in cancer cachexia. Dimens Crit Care Nurs. 23:237–243. 2004. View Article : Google Scholar : PubMed/NCBI

8 

La Vecchia S and Sebastián C: Metabolic pathways regulating colorectal cancer initiation and progression. Semin Cell Dev Biol. 98:63–70. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Lewis NE and Abdel-Haleem AM: The evolution of genome-scale models of cancer metabolism. Front Physiol. 4:2372013. View Article : Google Scholar : PubMed/NCBI

10 

Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, Tabata S, Saitoh K, Kato K, Sato S, et al: Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC. Proc Natl Acad Sci USA. 114:E7697–E7706. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Schcolnik-Cabrera A, Dominguez-Gómez G, Chávez-Blanco A, Ramírez-Yautentzi M, Morales-Bárcenas R, Chávez-Díaz J, Taja-Chayeb L and Dueáas-González A: A combination of inhibitors of glycolysis, glutaminolysis and de novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells. Oncol Lett. 18:6909–6916. 2019.PubMed/NCBI

12 

Cervantes-Madrid D and Dueñas-González A: Antitumor effects of a drug combination targeting glycolysis, glutaminolysis and de novo synthesis of fatty acids. Oncol Rep. 34:1533–1542. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Maimaiti M, Tanahashi Y, Mohri Z and Fujieda K: Development of a bioassay system for human growth hormone determination with close correlation to immunoassay. J Clin Lab Anal. 26:328–335. 2012. View Article : Google Scholar : PubMed/NCBI

14 

de la Peña A, Riddle M, Morrow LA, Jiang HH, Linnebjerg H, Scott A, Win KM, Hompesch M, Mace KF, Jacobson JG, et al: Pharmacokinetics and pharmacodynamics of high-dose human regular U-500 insulin versus human regular U-100 insulin in healthy obese subjects. Diabetes Care. 34:2496–2501. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Manvelian G, Daniels S and Altman R: A phase I study evaluating the pharmacokinetic profile of a novel, proprietary, nano-formulated, lower-dose oral indomethacin. Postgrad Med. 124:197–205. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Schneider CA, Rasband WS and Eliceiri KW: NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 9:671–675. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Zaytseva YY, Harris JW, Mitov MI, Kim JT, Butterfield DA, Lee EY, Weiss HL, Gao T and Evers BM: Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration. Oncotarget. 6:18891–18904. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Pavlova NN and Thompson CB: The Emerging Hallmarks of Cancer Metabolism. Cell Metab. 23:27–47. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Clem BF, O'Neal J, Klarer AC, Telang S and Chesney J: Clinical development of cancer therapeutics that target metabolism. QJM. 109:367–372. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Cervantes-Madrid D, Romero Y and Dueñas-González A: Reviving lonidamine and 6-diazo-5-oxo-l-norleucine to be used in combination for metabolic cancer therapy. BioMed Res Int. 2015:6904922015. View Article : Google Scholar : PubMed/NCBI

21 

Kridel SJ, Axelrod F, Rozenkrantz N and Smith JW: Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res. 64:2070–2075. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Schcolnik-Cabrera A, Chávez-Blanco A, Domínguez-Gómez G, Taja-Chayeb L, Morales-Barcenas R, Trejo-Becerril C, Perez-Cardenas E, Gonzalez-Fierro A and Dueñas-González A: Orlistat as a FASN inhibitor and multitargeted agent for cancer therapy. Expert Opin Investig Drugs. 27:475–489. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Bhutia YD, Babu E and Ganapathy V: Re-programming tumour cell metabolism to treat cancer: No lone target for lonidamine. Biochem J. 473:1503–1506. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Thangavelu K, Chong QY, Low BC and Sivaraman J: Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA). Sci Rep. 4:38272014. View Article : Google Scholar : PubMed/NCBI

25 

Pemble CW IV, Johnson LC, Kridel SJ and Lowther WT: Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. Nat Struct Mol Biol. 14:704–709. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Schcolnik-Cabrera A, Chávez-Blanco A, Domínguez-Gómez G and Dueñas-González A: Understanding tumor anabolism and patient catabolism in cancer-associated cachexia. Am J Cancer Res. 7:1107–1135. 2017.PubMed/NCBI

27 

Mondello P, Mian M, Aloisi C, Famà F, Mondello S and Pitini V: Cancer cachexia syndrome: Pathogenesis, diagnosis, and new therapeutic options. Nutr Cancer. 67:12–26. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Manson JM and Wilmore DW: Positive nitrogen balance with human growth hormone and hypocaloric intravenous feeding. Surgery. 100:188–197. 1986.PubMed/NCBI

29 

Ward HC, Halliday D and Sim AJ: Protein and energy metabolism with biosynthetic human growth hormone after gastrointestinal surgery. Ann Surg. 206:56–61. 1987. View Article : Google Scholar : PubMed/NCBI

30 

Cersosimo E, Pisters PW, Pesola G, Rogatko A, Vydelingum NA, Bajorunas D and Brennan MF: The effect of graded doses of insulin on peripheral glucose uptake and lactate release in cancer cachexia. Surgery. 109:459–467. 1991.PubMed/NCBI

31 

Pearlstone DB, Wolf RF, Berman RS, Burt M and Brennan MF: Effect of systemic insulin on protein kinetics in postoperative cancer patients. Ann Surg Oncol. 1:321–332. 1994. View Article : Google Scholar : PubMed/NCBI

32 

Moley JF, Morrison SD and Norton JA: Insulin reversal of cancer cachexia in rats. Cancer Res. 45:4925–4931. 1985.PubMed/NCBI

33 

Noguchi Y, Nomura K, Yoshikawa T, Fukuzawa K, Makino T, Tsuburaya A and Matsumoto A: Role of insulin resistance in decreasing lipoprotein lipase activity in tumor-bearing rats. Surg Today. 26:271–275. 1996. View Article : Google Scholar : PubMed/NCBI

34 

Hitt A, Graves E and McCarthy DO: Indomethacin preserves muscle mass and reduces levels of E3 ligases and TNF receptor type 1 in the gastrocnemius muscle of tumor-bearing mice. Res Nurs Health. 28:56–66. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Lundholm K, Daneryd P, Körner U, Hyltander A and Bosaeus I: Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia. Int J Oncol. 24:505–512. 2004.PubMed/NCBI

36 

Griffiths M, Keast D, Patrick G, Crawford M and Palmer TN: The role of glutamine and glucose analogues in metabolic inhibition of human myeloid leukaemia in vitro. Int J Biochem. 25:1749–1755. 1993. View Article : Google Scholar : PubMed/NCBI

37 

Meijer TWH, Peeters WJM, Dubois LJ, van Gisbergen MW, Biemans R, Venhuizen JH, Span PN and Bussink J: Targeting glucose and glutamine metabolism combined with radiation therapy in non-small cell lung cancer. Lung Cancer. 126:32–40. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Cohen P, Clemmons DR and Rosenfeld RG: Does the GH-IGF axis play a role in cancer pathogenesis? Growth Horm IGF Res. 10:297–305. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Chen JY, Liang DM, Gan P, Zhang Y and Lin J: In vitro effects of recombinant human growth hormone on growth of human gastric cancer cell line BGC823 cells. World J Gastroenterol. 10:1132–1136. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Liang DM, Chen JY, Zhang Y, Gan P, Lin J and Chen AB: Effects of recombinant human growth hormone on growth of human gastric carcinoma xenograft model in nude mice. World J Gastroenterol. 12:3810–3813. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Harrison LE, Blumberg D, Berman R, Ng B, Hochwald S, Brennan MF and Burt M: Effect of human growth hormone on human pancreatic carcinoma growth, protein, and cell cycle kinetics. J Surg Res. 61:317–322. 1996. View Article : Google Scholar : PubMed/NCBI

42 

Lu CC, Chu PY, Hsia SM, Wu CH, Tung YT and Yen GC: Insulin induction instigates cell proliferation and metastasis in human colorectal cancer cells. Int J Oncol. 50:736–744. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Chen X, Liang H, Song Q, Xu X and Cao D: Insulin promotes progression of colon cancer by upregulation of ACAT1. Lipids Health Dis. 17:1222018. View Article : Google Scholar : PubMed/NCBI

44 

Dulskas A, Patasius A, Linkeviciute-Ulinskiene D, Zabuliene L and Smailyte G: A cohort study of antihyperglycemic medication exposure and survival in patients with gastric cancer. Aging (Albany NY). 11:7197–7205. 2019.PubMed/NCBI

45 

Baglia ML, Cui Y, Zheng T, Yang G, Li H, You M, Xu L, Murff H, Gao YT, Zheng W, et al: Diabetes medication use in association with survival among patients of breast, colorectal, lung, or gastric cancer. Cancer Res Treat. 51:538–546. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Karlstad O, Starup-Linde J, Vestergaard P, Hjellvik V, Bazelier MT, Schmidt MK, Andersen M, Auvinen A, Haukka J, Furu K, et al: Use of insulin and insulin analogs and risk of cancer - systematic review and meta-analysis of observational studies. Curr Drug Saf. 8:333–348. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Schcolnik‑Cabrera A, Chavez‑Blanco A, Dominguez‑Gomez G, Juarez M, Lai D, Hua S, Tovar AR, Diaz‑Chavez J and Duenas‑Gonzalez A: The combination of orlistat, lonidamine and 6‑diazo‑5‑oxo‑L‑norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells. Oncol Lett 20: 3053-3060, 2020.
APA
Schcolnik‑Cabrera, A., Chavez‑Blanco, A., Dominguez‑Gomez, G., Juarez, M., Lai, D., Hua, S. ... Duenas‑Gonzalez, A. (2020). The combination of orlistat, lonidamine and 6‑diazo‑5‑oxo‑L‑norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells. Oncology Letters, 20, 3053-3060. https://doi.org/10.3892/ol.2020.11838
MLA
Schcolnik‑Cabrera, A., Chavez‑Blanco, A., Dominguez‑Gomez, G., Juarez, M., Lai, D., Hua, S., Tovar, A. R., Diaz‑Chavez, J., Duenas‑Gonzalez, A."The combination of orlistat, lonidamine and 6‑diazo‑5‑oxo‑L‑norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells". Oncology Letters 20.3 (2020): 3053-3060.
Chicago
Schcolnik‑Cabrera, A., Chavez‑Blanco, A., Dominguez‑Gomez, G., Juarez, M., Lai, D., Hua, S., Tovar, A. R., Diaz‑Chavez, J., Duenas‑Gonzalez, A."The combination of orlistat, lonidamine and 6‑diazo‑5‑oxo‑L‑norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells". Oncology Letters 20, no. 3 (2020): 3053-3060. https://doi.org/10.3892/ol.2020.11838
Copy and paste a formatted citation
x
Spandidos Publications style
Schcolnik‑Cabrera A, Chavez‑Blanco A, Dominguez‑Gomez G, Juarez M, Lai D, Hua S, Tovar AR, Diaz‑Chavez J and Duenas‑Gonzalez A: The combination of orlistat, lonidamine and 6‑diazo‑5‑oxo‑L‑norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells. Oncol Lett 20: 3053-3060, 2020.
APA
Schcolnik‑Cabrera, A., Chavez‑Blanco, A., Dominguez‑Gomez, G., Juarez, M., Lai, D., Hua, S. ... Duenas‑Gonzalez, A. (2020). The combination of orlistat, lonidamine and 6‑diazo‑5‑oxo‑L‑norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells. Oncology Letters, 20, 3053-3060. https://doi.org/10.3892/ol.2020.11838
MLA
Schcolnik‑Cabrera, A., Chavez‑Blanco, A., Dominguez‑Gomez, G., Juarez, M., Lai, D., Hua, S., Tovar, A. R., Diaz‑Chavez, J., Duenas‑Gonzalez, A."The combination of orlistat, lonidamine and 6‑diazo‑5‑oxo‑L‑norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells". Oncology Letters 20.3 (2020): 3053-3060.
Chicago
Schcolnik‑Cabrera, A., Chavez‑Blanco, A., Dominguez‑Gomez, G., Juarez, M., Lai, D., Hua, S., Tovar, A. R., Diaz‑Chavez, J., Duenas‑Gonzalez, A."The combination of orlistat, lonidamine and 6‑diazo‑5‑oxo‑L‑norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells". Oncology Letters 20, no. 3 (2020): 3053-3060. https://doi.org/10.3892/ol.2020.11838
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