Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.xlsx
    • Supplementary_Data2.xlsx
    • Supplementary_Data3.xlsx
Article Open Access

High expression of EMP1 predicts a poor prognosis and correlates with immune infiltrates in bladder urothelial carcinoma

  • Authors:
    • Bo Lin
    • Tianwen Zhang
    • Xin Ye
    • Hongyu Yang
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2840-2854
    |
    Published online on: July 9, 2020
       https://doi.org/10.3892/ol.2020.11841
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Epithelial membrane protein 1 (EMP1) is a key gene that regulates cell proliferation and metastatic capability in various types of cancer, and serves an important role in tumor‑immune interactions. However, the association between EMP1 and clinical prognosis, as well as the presence of tumor‑infiltrating lymphocytes in bladder urothelial carcinoma (BLCA) remains unclear. The present study aimed to explore the relationship between EMP1 expression and tumor immune cell infiltration in BLCA. In the present study, EMP1 expression in BLCA was analyzed using the Oncomine database, The Cancer Genome Atlas (TCGA) and the Tumor Immune Estimation Resource (TIMER). The effects of EMP1 on clinical prognosis were evaluated using the Kaplan‑Meier plotter and Gene Expression Profiling Interactive Analysis. The correlations between EMP1, cancer immune infiltrates and lymphocyte abundance were determined using the TIMER and Tumor immune system interaction database. In addition, correlations between EMP1 expression and gene markers in immune infiltrates were analyzed using cBioportal. The results demonstrated that, compared with adjacent normal tissues, EMP1 was downregulated in BLCA tissues. High expression of EMP1 was significantly associated with poor overall survival (OS) in BLCA cases obtained from TCGA. Multivariate Cox analysis revealed that EMP1 was an independent predictor of OS in patients with BLCA. Gene set enrichment analysis revealed that EMP1 was associated with cancer‑related pathways and was positively correlated with the levels of infiltrating CD8+ T cells, macrophages, neutrophils and dendritic cells in BLCA. Further analysis demonstrated that EMP1 was significantly associated with the enrichment of multiple types of lymphocyte. EMP1 expression exhibited a strong correlation with a range of immune markers in BLCA. In conclusion, the results of the present study demonstrated that EMP1 was associated with a poor prognosis in patients with BLCA, and that the levels of immune infiltration and multiple immunomarker groups were associated with EMP1 expression. These results suggested that EMP1 may be used as a predictive biomarker to determine the prognosis and immune infiltration in BLCA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global Cancer Statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Burger M, Catto JW, Dalbagni G, Grossman HB, Herr H, Karakiewicz P, Kassouf W, Kiemeney LA, La Vecchia C, Shariat S, et al: Epidemiology and risk factors of urothelial bladder cancer. Eur Urol. 63:234–241. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Cumberbatch MGK, Jubber I, Black PC, Esperto F, Figueroa JD, Kamat AM, Kiemeney L, Lotan Y, Pang K, Silverman DT, et al: Epidemiology of bladder cancer: A systematic review and contemporary update of risk factors in 2018. Eur Urol. 74:784–795. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Obara W, Eto M, Mimata H, Kohri K, Mitsuhata N, Miura I, Shuin T, Miki T, Koie T, Fujimoto H, et al: A phase I/II study of cancer peptide vaccine S-288310 in patients with advanced urothelial carcinoma of the bladder. Ann Oncol. 28:798–803. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Lavoie JM, Bidnur S, Black PC and Eigl BJ: Expanding immunotherapy options for bladder cancer: commentary on: Pembrolizumab as second-line therapy for advanced urothelial carcinoma. Urology. 106:1–2. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Hamilou Z, Lavaud P and Loriot Y: Atezolizumab in urothelial bladder carcinoma. Future Oncol. 14:331–341. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Kamat AM, Bellmunt J, Galsky MD, Konety BR, Lamm DL, Langham D, Lee CT, Milowsky MI, ODonnell MA, ODonnell PH, et al: Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of bladder carcinoma. J Immunother Cancer. 5:682017. View Article : Google Scholar : PubMed/NCBI

8 

Liu YN, Zhang H, Zhang L, Cai TT, Huang DJ, He J, Ni HH, Zhou FJ, Zhang XS and Li J: Sphingosine 1 phosphate receptor-1 (S1P1) promotes tumor-associated regulatory T cell expansion: Leading to poor survival in bladder cancer. Cell Death Dis. 10:502019. View Article : Google Scholar : PubMed/NCBI

9 

Mukherjee N, Ji N, Hurez V, Curiel TJ, Montgomery MO, Braun AJ, Nicolas M, Aguilera M, Kaushik D, Liu Q, et al: Intratumoral CD56bright natural killer cells are associated with improved survival in bladder cancer. Oncotarget. 9:36492–36502. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Sjödahl G, Lövgren K, Lauss M, Chebil G, Patschan O, Gudjonsson S, Månsson W, Fernö M, Leandersson K, Lindgren D, et al: Infiltration of CD3+ and CD68+ cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors. Urol Oncol. 32:791–797. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Wang B, Xie S, Bi J, Liu Z, Zeng H, Huang H, Xue M, He Z, Yang M, Yu H, et al: Elevated pre-existing lymphocytic infiltrates in tumour stroma predict poor prognosis in resectable urothelial carcinoma of the bladder. Histopathology. 75:354–364. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Sun GG, Lu YF, Fu ZZ, Cheng YJ and Hu WN: EMP1 inhibits nasopharyngeal cancer cell growth and metastasis through induction apoptosis and angiogenesis. Tumour Biol. 35:3185–3193. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Sun G, Zhao G, Lu Y, Wang Y and Yang C: Association of EMP1 with gastric carcinoma invasion, survival and prognosis. Int J Oncol. 45:1091–1098. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Sun GG, Wang YD, Cui DW, Cheng YJ and Hu WN: Epithelial membrane protein 1 negatively regulates cell growth and metastasis in colorectal carcinoma. World J Gastroenterol. 20:4001–4010. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Sun GG, Wang YD, Lu YF and Hu WN: EMP1, a member of a new family of antiproliferative genes in breast carcinoma. Tumour Biol. 35:3347–3354. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Sun GG, Wang YD, Cui DW, Cheng YJ and Hu WN: EMP1 regulates caspase-9 and VEGFC expression and suppresses prostate cancer cell proliferation and invasion. Tumour Biol. 35:3455–3462. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Ariës IM, Jerchel IS, van den Dungen RE, van den Berk LC, Boer JM, Horstmann MA, Escherich G, Pieters R and den Boer ML: EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion. Leukemia. 28:1828–1837. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Jain A, Tindell CA, Laux I, Hunter JB, Curran J, Galkin A, Afar DE, Aronson N, Shak S, Natale RB, et al: Epithelial membrane protein-1 is a biomarker of gefitinib resistance. Proc Natl Acad Sci USA. 102:11858–11863. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Ben-Porath I and Benvenisty N: Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. Gene. 183:69–75. 1996. View Article : Google Scholar : PubMed/NCBI

20 

Li YQ, Xue T, Wang L, Xu ZC, Xi ZQ, Yuan J, Wang XF, Chen YM, Zhang M and Yao L: Up-regulation of epithelial membrane protein-1 in the temporal neocortex of patients with intractable epilepsy. Neurochem Res. 34:1594–1602. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Ramnarain DB, Park S, Lee DY, Hatanpaa KJ, Scoggin SO, Otu H, Libermann TA, Raisanen JM, Ashfaq R, Wong ET, et al: Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells. Cancer Res. 66:867–874. 2006. View Article : Google Scholar : PubMed/NCBI

22 

De Marco C, Laudanna C, Rinaldo N, Oliveira DM, Ravo M, Weisz A, Ceccarelli M, Caira E, Rizzuto A, Zoppoli P, et al: Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer. PLoS One. 12:e01788652017. View Article : Google Scholar : PubMed/NCBI

23 

Wang YW, Li WM, Wu WJ, Chai CY, Chang TY, Sun Y, Cheng CJ, Shiue YL, Su SJ, Cheng HL, et al: Epithelial membrane protein 2 is a prognostic indictor for patients with urothelial carcinoma of the upper urinary tract. Am J Pathol. 183:709–719. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Humphrey PA, Moch H, Cubilla AL, Ulbright TM and Reuter VE: The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and bladder tumours. Eur Urol. 70:106–119. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Demirag GG, Kefeli M, Kemal Y and Yucel I: Epithelial membrane protein 1 expression in ovarian serous tumors. Oncol Lett. 11:2140–2144. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Li B and Dewey CN: RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics. 12:3232011. View Article : Google Scholar : PubMed/NCBI

27 

Team R: Core. A language and environment for statistical computing. R Foundation for Statistical Computing. 2014.

28 

Yoshihara K, Shahmoradgoli M, Martínez E, Vegesna R, Kim H, Torres-Garcia W, Treviño V, Shen H, Laird PW, Levine DA, et al: Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 4:26122013. View Article : Google Scholar : PubMed/NCBI

29 

Nagy Á, Lánczky A, Menyhárt O and Győrffy B: Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 8:92272018. View Article : Google Scholar : PubMed/NCBI

30 

Ru B, Wong CN, Tong Y, Zhong JY, Zhong SSW, Wu WC, Chu KC, Wong CY, Lau CY, Chen I, et al: TISIDB: An integrated repository portal for tumor-immune system interactions. Bioinformatics. 35:4200–4202. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

32 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Peter S, Borkowska E, Drayton RM, Rakhit CP, Noon A, Chen W and Catoo JW: Identification of differentially expressed long noncoding RNAs in bladder cancer. Clin Cancer Res. 20:5311–21. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Ben-Porath I, Kozak CA and Benvenisty N: Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3), genes encoding membrane proteins related to Pmp22. Genomics. 49:443–447. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Chen Y, Medvedev A, Ruzanov P, Marvin KW and Jetten AM: cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family. Genomics. 41:40–48. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Ahmat Amin MKB, Shimizu A and Ogita H: The pivotal roles of the epithelial membrane protein family in cancer invasiveness and metastasis. Cancers (Basel). 11:112019. View Article : Google Scholar

37 

Da Y and Jia J: Study of antibodies to PMP22, IL-6 and TNF-alpha concentrations in serum in a CMTX1 family. Neurosci Lett. 424:73–77. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Gabriel CM, Gregson NA and Hughes RA: Anti-PMP22 antibodies in patients with inflammatory neuropathy. J Neuroimmunol. 104:139–146. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Kornberg LJ, Villaret D, Popp M, Lui L, McLaren R, Brown H, Cohen D, Yun J and McFadden M: Gene expression profiling in squamous cell carcinoma of the oral cavity shows abnormalities in several signaling pathways. Laryngoscope. 115:690–698. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Kuriakose MA, Chen WT, He ZM, Sikora AG, Zhang P, Zhang ZY, Qiu WL, Hsu DF, McMunn-Coffran C, Brown SM, et al: Selection and validation of differentially expressed genes in head and neck cancer. Cell Mol Life Sci. 61:1372–1383. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Hippo Y, Yashiro M, Ishii M, Taniguchi H, Tsutsumi S, Hirakawa K, Kodama T and Aburatani H: Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. Cancer Res. 61:889–895. 2001.PubMed/NCBI

42 

Wei Q, Li M, Fu X, Tang R, Na Y, Jiang M and Li Y: Global analysis of differentially expressed genes in androgen-independent prostate cancer. Prostate Cancer Prostatic Dis. 10:167–174. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Arslan AA, Gold LI, Mittal K, Suen TC, Belitskaya-Levy I, Tang MS and Toniolo P: Gene expression studies provide clues to the pathogenesis of uterine leiomyoma: New evidence and a systematic review. Hum Reprod. 20:852–863. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Zhang J, Cao W, Xu Q and Chen WT: The expression of EMP1 is downregulated in oral squamous cell carcinoma and possibly associated with tumour metastasis. J Clin Pathol. 64:25–29. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Lai S, Wang G, Cao X, Li Z, Hu J and Wang J: EMP-1 promotes tumorigenesis of NSCLC through PI3K/AKT pathway. J Huazhong Univ Sci Technolog Med Sci. 32:834–838. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Zhang Ht: Lu YcandHe J. Expression of epithelial membrane protein 1 in human gliomas and its clinical implications. Zhongguo Zhongliu Shengwu Zhiliao Zazhi. 14:466–470. 2007.

47 

Turashvili G, Bouchal J, Baumforth K, Wei W, Dziechciarkova M, Ehrmann J, Klein J, Fridman E, Skarda J, Srovnal J, et al: Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis. BMC Cancer. 7:552007. View Article : Google Scholar : PubMed/NCBI

48 

Mackay A, Jones C, Dexter T, Silva RL, Bulmer K, Jones A, Simpson P, Harris RA, Jat PS, Neville AM, et al: cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells. Oncogene. 22:2680–2688. 2003. View Article : Google Scholar : PubMed/NCBI

49 

Lobsiger CS, Magyar JP, Taylor V, Wulf P, Welcher AA, Program AE and Suter U: Identification and characterization of a cDNA and the structural gene encoding the mouse epithelial membrane protein-1. Genomics. 36:379–387. 1996. View Article : Google Scholar : PubMed/NCBI

50 

Wang HT, Kong JP, Ding F, Wang XQ, Wang MR, Liu LX, Wu M and Liu ZH: Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA Microarray. World J Gastroenterol. 9:392–398. 2003. View Article : Google Scholar : PubMed/NCBI

51 

Ruegg CL, Wu HY, Fagnoni FF, Engleman EG and Laus R: B4B, a novel growth-arrest gene, is expressed by a subset of progenitor/pre-B lymphocytes negative for cytoplasmic mu-chain. J Immunol. 157:72–80. 1996.PubMed/NCBI

52 

Wang YW, Cheng HL, Ding YR, Chou LH and Chow NH: EMP1, EMP 2, and EMP3 as novel therapeutic targets in human cancer. Biochim Biophys Acta Rev Cancer. 1868:199–211. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Durgan J, Tao G, Walters MS, Florey O, Schmidt A, Arbelaez V, Rosen N, Crystal RG and Hall A: SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1. EMBO Rep. 16:87–96. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Morales SA, Telander DG, Mareninov S, Nagy A, Wadehra M, Braun J and Gordon LK: Anti-EMP2 diabody blocks epithelial membrane protein 2 (EMP2) and FAK mediated collagen gel contraction in ARPE-19 cells. Exp Eye Res. 102:10–16. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Wadehra M, Forbes A, Pushkarna N, Goodglick L, Gordon LK, Williams CJ and Braun J: Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium. Dev Biol. 287:336–345. 2005. View Article : Google Scholar : PubMed/NCBI

56 

Morales SA, Mareninov S, Wadehra M, Zhang L, Goodglick L, Braun J and Gordon LK: FAK activation and the role of epithelial membrane protein 2 (EMP2) in collagen gel contraction. Invest Ophthalmol Vis Sci. 50:462–469. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Wadehra M, Goodglick L and Braun J: The tetraspan protein EMP2 modulates the surface expression of caveolins and glycosylphosphatidyl inositol-linked proteins. Mol Biol Cell. 15:2073–2083. 2004. View Article : Google Scholar : PubMed/NCBI

58 

Ayari C, LaRue H, Hovington H, Caron A, Bergeron A, Têtu B, Fradet V and Fradet Y: High level of mature tumor-infiltrating dendritic cells predicts progression to muscle invasion in bladder cancer. Hum Pathol. 44:1630–1637. 2013. View Article : Google Scholar : PubMed/NCBI

59 

Pichler R, Fritz J, Zavadil C, Schäfer G, Culig Z and Brunner A: Tumor-infiltrating immune cell subpopulations influence the oncologic outcome after intravesical Bacillus Calmette-Guérin therapy in bladder cancer. Oncotarget. 7:39916–39930. 2016. View Article : Google Scholar : PubMed/NCBI

60 

Kawahara T, Furuya K, Nakamura M, Sakamaki K, Osaka K, Ito H, Ito Y, Izumi K, Ohtake S, Miyoshi Y, et al: Neutrophil-to-lymphocyte ratio is a prognostic marker in bladder cancer patients after radical cystectomy. BMC Cancer. 16:1852016. View Article : Google Scholar : PubMed/NCBI

61 

Peng D, Gong YQ, Hao H, He ZS, Li XS, Zhang CJ and Zhou LQ: Preoperative prognostic nutritional index is a significant predictor of survival with bladder cancer after radical cystectomy: A retrospective study. BMC Cancer. 17:3912017. View Article : Google Scholar : PubMed/NCBI

62 

Hamilton-Reeves JM, Bechtel MD, Hand LK, Schleper A, Yankee TM, Chalise P, Lee EK, Mirza M, Wyre H, Griffin J, et al: Effects of immunonutrition for cystectomy on immune response and infection rates: A pilot randomized controlled clinical trial. Eur Urol. 69:389–392. 2016. View Article : Google Scholar : PubMed/NCBI

63 

Demirer Z and Uslu AU: Predictive value of neutrophil-lymphocyte ratio in non-muscle-invasive bladder cancer. Urol Oncol. 34:1–2. 2016. View Article : Google Scholar : PubMed/NCBI

64 

Zhou L, Xu L, Chen L, Fu Q, Liu Z, Chang Y, Lin Z and Xu J: Tumor-infiltrating neutrophils predict benefit from adjuvant chemotherapy in patients with muscle invasive bladder cancer. OncoImmunology. 6:e12932112017. View Article : Google Scholar : PubMed/NCBI

65 

Zhang Q, Hao C, Cheng G, Wang L, Wang X, Li C, Qiu J and Ding K: High CD4+ T cell density is associated with poor prognosis in patients with non-muscle-invasive bladder cancer. Int J Clin Exp Pathol. 8:11510–11516. 2015.PubMed/NCBI

66 

Pfannstiel C, Strissel PL, Chiappinelli KB, Sikic D, Wach S, Wirtz RM, Wullweber A, Taubert H, Breyer J, Otto W, et al BRIDGE Consortium Germany; BRIDGE Consortium Germany; BRIDGE Consortium Germany; BRIDGE Consortium Germany, : The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes. Cancer Immunol Res. 7:923–938. 2019. View Article : Google Scholar : PubMed/NCBI

67 

Wu K, Tan MY, Jiang JT, Mu XY, Wang JR, Zhou WJ, Wang X, Li MQ, He YY and Liu ZH: Cisplatin inhibits the progression of bladder cancer by selectively depleting G-MDSCs: A novel chemoimmunomodulating strategy. Clin Immunol. 193:60–69. 2018. View Article : Google Scholar : PubMed/NCBI

68 

Smith SG, Baltz JL, Koppolu BP, Ravindranathan S, Nguyen K and Zaharoff DA: Immunological mechanisms of intravesical chitosan/interleukin-12 immunotherapy against murine bladder cancer. OncoImmunology. 6:e12590502016. View Article : Google Scholar : PubMed/NCBI

69 

Horn T, Laus J, Seitz AK, Maurer T, Schmid SC, Wolf P, Haller B, Winkler M, Retz M, Nawroth R, et al: The prognostic effect of tumour-infiltrating lymphocytic subpopulations in bladder cancer. World J Urol. 34:181–187. 2016. View Article : Google Scholar : PubMed/NCBI

70 

Winerdal ME, Krantz D, Hartana CA, Zirakzadeh AA, Linton L, Bergman EA, Rosenblatt R, Vasko J, Alamdari F, Hansson J, et al: Urinary bladder cancer tregs suppress MMP2 and potentially regulate invasiveness. Cancer Immunol Res. 6:528–538. 2018. View Article : Google Scholar : PubMed/NCBI

71 

Wang Q, Chang W, Yang X, Cheng Y, Zhao X, Zhou L, Li J, Li J and Zhang K: Levels of miR-31 and its target genes in dermal mesenchymal cells of patients with psoriasis. Int J Dermatol. 58:198–204. 2019. View Article : Google Scholar : PubMed/NCBI

72 

Pan L, Yang H, Tang W, Xu C, Chen S, Meng Z, Li K and Chen H: Pathway-focused PCR array profiling of CAL-27 cell with over-expressed ZNF750. Oncotarget. 9:566–575. 2017. View Article : Google Scholar : PubMed/NCBI

73 

Wang Y, Chaudhri G, Jackson RJ and Karupiah G: IL-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection. J Immunol. 183:3324–3331. 2009. View Article : Google Scholar : PubMed/NCBI

74 

Kehrmann J, Effenberg L, Wilk C, Schoemer D, Ngo Thi Phuong N, Adamczyk A, Pastille E, Scholtysik R, Klein-Hitpass L, Klopfleisch R, et al: Depletion of Foxp3+ regulatory T cells is accompanied by an increase in the relative abundance of Firmicutes in the murine gut microbiome. Immunology. 159:344–353. 2020. View Article : Google Scholar : PubMed/NCBI

75 

Sperk M, Domselaar RV and Neogi U: Immune checkpoints as the immune system regulators and potential biomarkers in HIV-1 infection. Int J Mol Sci. 19:192018. View Article : Google Scholar

76 

Chan AW, Zhang Z, Chong CC, Tin EK, Chow C and Wong N: Genomic landscape of lymphoepithelioma-like hepatocellular carcinoma. J Pathol. 249:166–172. 2019. View Article : Google Scholar : PubMed/NCBI

77 

Yoshikawa T, Nakatsugawa M, Suzuki S, Shirakawa H, Nobuoka D, Sakemura N, Motomura Y, Tanaka Y, Hayashi S and Nakatsura T: HLA-A2-restricted glypican-3 peptide-specific CTL clones induced by peptide vaccine show high avidity and antigen-specific killing activity against tumor cells. Cancer Sci. 102:918–925. 2011. View Article : Google Scholar : PubMed/NCBI

78 

Germeau C, Ma W, Schiavetti F, Lurquin C, Henry E, Vigneron N, Brasseur F, Lethé B, De Plaen E, Velu T, et al: High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumor antigens. J Exp Med. 201:241–248. 2005. View Article : Google Scholar : PubMed/NCBI

79 

Takashima Y, Kawaguchi A, Sato R, Yoshida K, Hayano A, Homma J, Fukai J, Iwadate Y, Kajiwara K, Ishizawa S, et al: Differential expression of individual transcript variants of PD-1 and PD-L2 genes on Th-1/Th-2 status is guaranteed for prognosis prediction in PCNSL. Sci Rep. 9:100042019. View Article : Google Scholar : PubMed/NCBI

80 

Zhou G, Sprengers D, Boor PPC, Doukas M, Schutz H, Mancham S, Pedroza-Gonzalez A, Polak WG, de Jonge J, Gaspersz M, et al: Antibodies against immune checkpoint molecules restore functions of tumor-infiltrating T cells in hepatocellular carcinomas. Gastroenterology. 153:1107–1119e10. 2017. View Article : Google Scholar : PubMed/NCBI

81 

Kim JY, Lee E, Park K, Park WY, Jung HH, Ahn JS, Im YH and Park YH: Immune signature of metastatic breast cancer: Identifying predictive markers of immunotherapy response. Oncotarget. 8:47400–47411. 2017. View Article : Google Scholar : PubMed/NCBI

82 

Flecken T, Schmidt N, Hild S, Gostick E, Drognitz O, Zeiser R, Schemmer P, Bruns H, Eiermann T, Price DA, et al: Immunodominance and functional alterations of tumor-associated antigen-specific CD8+ T-cell responses in hepatocellular carcinoma. Hepatology. 59:1415–1426. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lin B, Zhang T, Ye X and Yang H: High expression of EMP1 predicts a poor prognosis and correlates with immune infiltrates in bladder urothelial carcinoma. Oncol Lett 20: 2840-2854, 2020.
APA
Lin, B., Zhang, T., Ye, X., & Yang, H. (2020). High expression of EMP1 predicts a poor prognosis and correlates with immune infiltrates in bladder urothelial carcinoma. Oncology Letters, 20, 2840-2854. https://doi.org/10.3892/ol.2020.11841
MLA
Lin, B., Zhang, T., Ye, X., Yang, H."High expression of EMP1 predicts a poor prognosis and correlates with immune infiltrates in bladder urothelial carcinoma". Oncology Letters 20.3 (2020): 2840-2854.
Chicago
Lin, B., Zhang, T., Ye, X., Yang, H."High expression of EMP1 predicts a poor prognosis and correlates with immune infiltrates in bladder urothelial carcinoma". Oncology Letters 20, no. 3 (2020): 2840-2854. https://doi.org/10.3892/ol.2020.11841
Copy and paste a formatted citation
x
Spandidos Publications style
Lin B, Zhang T, Ye X and Yang H: High expression of EMP1 predicts a poor prognosis and correlates with immune infiltrates in bladder urothelial carcinoma. Oncol Lett 20: 2840-2854, 2020.
APA
Lin, B., Zhang, T., Ye, X., & Yang, H. (2020). High expression of EMP1 predicts a poor prognosis and correlates with immune infiltrates in bladder urothelial carcinoma. Oncology Letters, 20, 2840-2854. https://doi.org/10.3892/ol.2020.11841
MLA
Lin, B., Zhang, T., Ye, X., Yang, H."High expression of EMP1 predicts a poor prognosis and correlates with immune infiltrates in bladder urothelial carcinoma". Oncology Letters 20.3 (2020): 2840-2854.
Chicago
Lin, B., Zhang, T., Ye, X., Yang, H."High expression of EMP1 predicts a poor prognosis and correlates with immune infiltrates in bladder urothelial carcinoma". Oncology Letters 20, no. 3 (2020): 2840-2854. https://doi.org/10.3892/ol.2020.11841
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team