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Determination of long non‑coding RNAs associated with EZH2 in neuroblastoma by RIP‑seq, RNA‑seq and ChIP‑seq

  • Authors:
    • Mujie Ye
    • Lulu Xie
    • Jingjing Zhang
    • Baihui Liu
    • Xiangqi Liu
    • Jiajun He
    • Duan Ma
    • Kuiran Dong
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai 201102, P.R. China, Department of Medical Imaging, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210001, P.R. China, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Institute of Biomedical Sciences, Collaborative Innovation Center of Genetics and Development, School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1
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    Published online on: July 13, 2020
       https://doi.org/10.3892/ol.2020.11862
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Abstract

Neuroblastoma (NB) is the most common type of extracranial solid tumor found in children. Despite several treatment options, patients with advanced stage disease have a poor prognosis. Previous studies have reported that enhancer of zeste homolog 2 (EZH2) and long non‑coding RNAs (lncRNAs) have abnormal expression levels in NB and participate in tumorigenesis and NB development. However, the association between EZH2 and lncRNAs remain unclear. In the present study, RNA immunoprecipitation‑sequencing (RIP‑seq) was used to analyze the lncRNAs binding to EZH2. Following EZH2 knockdown via short hairpin RNA, RNA‑seq was performed in shEZH2 and control groups in SH‑SY5Y cells. Chromatin IP (ChIP)‑seq was used to determine the genes that may be regulated by EZH2. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to identify the signaling pathways involved in NB. The results from RIP‑seq identified 94 lncRNAs, including SNHG7, SNHG22, KTN‑AS1 and Linc00843. Furthermore, results from RNA‑seq demonstrated that, following EZH2 knockdown, 448 genes were up‑ and 571 genes were downregulated, with 32 lncRNAs up‑ and 35 downregulated and differentially expressed compared with control groups. Certain lncRNAs, including MALAT1, H19, Linc01021 and SNHG5, were differentially expressed in EZH2‑knockdown group compared with the control group. ChIP‑seq identified EZH2 located in the promoter region of 138 lncRNAs including CASC16, CASC15, LINC00694 and TBX5‑AS1. In summary, the present study demonstrated that certain lncRNAs directly bound EZH2 and regulated EZH2 expression levels. A number of these lncRNAs that are associated with EZH2 may participate in NB tumorigenesis.
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1 

Alam MW, Boreas M, Lind DE, Cervantes-Madrid D, Umapathy G, Palmer RH and Hallberg B: Alectinib, an anaplastic lymphoma kinase inhibitor, abolishes ALK activity and growth in alk-positive neuroblastoma cells. Front Oncol. 9:5792019. View Article : Google Scholar : PubMed/NCBI

2 

Calvo C, Storey C, Morcrette G, Akl P, Freneaux P, Pierron G, Trang H, Aerts I, Schleiermacher G, Philippe-Chomette P, et al: Metastatic neuroblastoma in a patient with ROHHAD: A new alert regarding the risk of aggressive malignancies in this rare condition. Pediatr Blood Cancer. 66:e279062019.PubMed/NCBI

3 

Garcia M, Rodriguez-Hernandez CJ, Mateo-Lozano S, Perez-Jaume S, Goncalves-Alves E, Lavarino C, Mora J and de Torres C: Parathyroid hormone-like hormone plays a dual role in neuroblastoma depending on PTH1R expression. Mol Oncol. 13:1959–1975. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Grasso S, Cangelosi D, Chapelle J, Alzona M, Centonze G, Lamolinara A, Salemme V, Angelini C, Morellato A, Saglietto A, et al: The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma. Cell Death Differ. 27:790–807. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Bhoopathi P, Pradhan AK, Bacolod MD, Emdad L, Sarkar D, Das SK and Fisher PB: Regulation of neuroblastoma migration, invasion, and in vivo metastasis by genetic and pharmacological manipulation of MDA-9/syntenin. Oncogene. 38:6781–6793. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Pacenta HL and Macy ME: Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma. Drug Des Devel Ther. 12:3549–3561. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Campbell K, Shyr D, Bagatell R, Fischer M, Nakagawara A, Nieto AC, Brodeur GM, Matthay KK, London WB and DuBois SG: Comprehensive evaluation of context dependence of the prognostic impact of MYCN amplification in neuroblastoma: A report from the International Neuroblastoma Risk Group (INRG) project. Pediatr Blood Cancer. 66:e278192019. View Article : Google Scholar : PubMed/NCBI

8 

Yu Y, Chen F, Yang Y, Jin Y, Shi J, Han S, Chu P, Lu J, Tai J, Wang S, et al: lncRNA SNHG16 is associated with proliferation and poor prognosis of pediatric neuroblastoma. Int J Oncol. 55:93–102. 2019.PubMed/NCBI

9 

Avitabile M, Lasorsa VA, Cantalupo S, Cardinale A, Cimmino F, Montella A, Capasso D, Haupt R, Amoroso L, Garaventa A, et al: Association of PARP1 polymorphisms with response to chemotherapy in patients with high-risk neuroblastoma. J Cell Mol Med. 24:4072–4081. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Ye M, Ma J, Liu B, Liu X, Ma D and Dong K: Linc01105 acts as an oncogene in the development of neuroblastoma. Oncol Rep. 2019.(Epub ahead of print). View Article : Google Scholar

11 

Liu Z, Yang L, Zhong C and Zhou L: EZH2 regulates H2B phosphorylation and elevates colon cancer cell autophagy. J Cell Physiol. 235:1494–1503. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Kosalai ST, Morsy M, Papakonstantinou N, Mansouri L, Stavroyianni N, Kanduri C, Stamatopoulos K, Rosenquist R and Kanduri M: EZH2 upregulates the PI3K/AKT pathway through IGF1R and MYC in clinically aggressive chronic lymphocytic leukaemia. Epigeneticst. 14:1125–1140. 2019. View Article : Google Scholar

13 

Pediconi N, Salerno D, Lupacchini L, Angrisani A, Peruzzi G, De Smaele E, Levrero M and Belloni L: EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells. Cell Death Dis. 10:5182019. View Article : Google Scholar : PubMed/NCBI

14 

Kim KH and Roberts CW: Targeting EZH2 in cancer. Nat Med. 22:128–134. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Yan KS, Lin CY, Liao TW, Peng CM, Lee SC, Liu YJ, Chan WP and Chou RH: EZH2 in cancer progression and potential application in cancer therapy: A friend or foe? Int J Mol Sci. 18:11722017. View Article : Google Scholar

16 

Ma J, Zhang J, Weng YC and Wang JC: EZH2-mediated microRNA-139-5p regulates epithelial-mesenchymal transition and lymph node metastasis of pancreatic cancer. Mol Cells. 41:868–880. 2018.PubMed/NCBI

17 

Liu Q, Wang G, Li Q, Jiang W, Kim JS, Wang R, Zhu S, Wang X, Yan L, Yi Y, et al: Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer. Int J Cancer. 145:415–426. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Wang C, Liu Z, Woo CW, Li Z, Wang L, Wei JS, Marquez VE, Bates SE, Jin Q, Khan J, et al: EZH2 mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR. Cancer Res. 72:315–324. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Delas MJ, Jackson BT, Kovacevic T, Vangelisti S, Munera ME, Wild SA, Stork EM, Erard N, Knott S and Hannon GJ: lncRNA spehd regulates hematopoietic stem and progenitor cells and is required for multilineage differentiation. Cell Rep. 27:719–729.e6. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Zhong Y, Wang J, Lv W, Xu J, Mei S and Shan A: lncRNA TTN-AS1 drives invasion and migration of lung adenocarcinoma cells via modulation of miR-4677-3p/ZEB1 axis. J Cell Biochem. 120:17131–17141. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Cairns J, Ingle JN, Kalari KR, Shepherd LE, Kubo M, Goetz MP, Weinshilboum RM and Wang L: The lncRNA MIR2052HG regulates ERalpha levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1. Breast Cancer Res. 21:472019. View Article : Google Scholar : PubMed/NCBI

22 

Schmidt K, Carroll JS, Yee E, Thomas DD, Wert-Lamas L, Neier SC, Sheynkman G, Ritz J and Novina CD: The lncRNA SLNCR recruits the androgen receptor to EGR1-bound genes in melanoma and inhibits expression of tumor suppressor p21. Cell Rep. 27:2493–2507.e4. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Jin L, Cai Q, Wang S, Wang S, Mondal T, Wang J and Quan Z: Long noncoding RNA MEG3 regulates LATS2 by promoting the ubiquitination of EZH2 and inhibits proliferation and invasion in gallbladder cancer. Cell Death Dis. 9:10172018. View Article : Google Scholar : PubMed/NCBI

24 

Wang Y, Xie Y, Li L, He Y, Zheng D, Yu P, Yu L, Tang L, Wang Y and Wang Z: EZH2 RIP-seq identifies tissue-specific long non-coding RNAs. Curr Gene Ther. 18:275–285. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Su M, Xiao Y, Tang J, Wu J, Ma J, Tian B, Zhou Y, Wang H, Yang D, Liao QJ and Wang W: Role of lncRNA and EZH2 interaction/regulatory network in lung cancer. J Cancer. 9:4156–4165. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Kim B: Western blot techniques. Methods Mol Biol. 1606:133–139. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Gagliardi M and Matarazzo MR: RIP: RNA immunoprecipitation. Methods Mol Biol. 1480:73–86. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Xia W, Hu J, Ma J, Huang J, Jing T, Deng L, Zhang J, Jiang N, Ma D and Ma Z: Mutations in TOP2B cause autosomal-dominant hereditary hearing loss via inhibition of the PI3K-Akt signalling pathway. Febs Lett. 593:2008–2018. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Kong L, Tan L, Lv R, Shi Z, Xiong L, Wu F, Rabidou K, Smith M, He C, Zhang L, et al: A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands. Nucleic Acids Res. 44:8682–8692. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Ozcelik D and Pezacki JP: Small molecule inhibition of protein disulfide isomerase in neuroblastoma cells induces oxidative stress response and apoptosis pathways. Acs Chem Neurosci. 10:4068–4075. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Chen L, Alexe G, Dharia NV, Ross L, Iniguez AB, Conway AS, Wang EJ, Veschi V, Lam N, Qi J, et al: CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2. J Clin Invest. 128:446–462. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Li Z, Takenobu H, Setyawati AN, Akita N, Haruta M, Satoh S, Shinno Y, Chikaraishi K, Mukae K, Akter J, et al: EZH2 regulates neuroblastoma cell differentiation via NTRK1 promoter epigenetic modifications. Oncogene. 37:2714–2727. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Bellamy J, Szemes M, Melegh Z, Dallosso A, Kollareddy M, Catchpoole D and Malik K: Increased efficacy of histone methyltransferase G9a inhibitors against MYCN-amplified neuroblastoma. Front Oncol. 10:8182020. View Article : Google Scholar : PubMed/NCBI

34 

Tsubota S, Kishida S, Shimamura T, Ohira M, Yamashita S, Cao D, Kiyonari S, Ushijima T and Kadomatsu K: PRC2-mediated transcriptomic alterations at the embryonic stage govern tumorigenesis and clinical outcome in MYCN-driven neuroblastoma. Cancer Res. 77:5259–5271. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Bate-Eya LT, Gierman HJ, Ebus ME, Koster J, Caron HN, Versteeg R, Dolman M and Molenaar JJ: Enhancer of zeste homologue 2 plays an important role in neuroblastoma cell survival independent of its histone methyltransferase activity. Eur J Cancer. 75:63–72. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Zhao X, Li D, Huang D, Song H, Mei H, Fang E, Wang X, Yang F, Zheng L, Huang K and Tong Q: Risk-associated long noncoding RNA FOXD3-AS1 inhibits neuroblastoma progression by repressing PARP1-mediated activation of CTCF. Mol Ther. 26:755–773. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Li D, Wang X, Mei H, Fang E, Ye L, Song H, Yang F, Li H, Huang K, Zheng L and Tong Q: Long noncoding RNA pancEts-1 promotes neuroblastoma progression through hnRNPK-mediated β-catenin stabilization. Cancer Res. 78:1169–1183. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Wu Q, Xiang S, Ma J, Hui P, Wang T, Meng W, Shi M and Wang Y: Long non-coding RNA CASC15 regulates gastric cancer cell proliferation, migration and epithelial mesenchymal transition by targeting CDKN1A and ZEB1. Mol Oncol. 12:799–813. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Sanli I, Lalevee S, Cammisa M, Perrin A, Rage F, Lleres D, Riccio A, Bertrand E and Feil R: Meg3 non-coding RNA expression controls imprinting by preventing transcriptional upregulation in cis. Cell Rep. 23:337–348. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Wang M, Guo C, Wang L, Luo G, Huang C, Li Y, Liu D, Zeng F, Jiang G and Xiao X: Long noncoding RNA GAS5 promotes bladder cancer cells apoptosis through inhibiting EZH2 transcription. Cell Death Dis. 9:2382018. View Article : Google Scholar : PubMed/NCBI

41 

Zheng W and Yu A: EZH2-mediated suppression of lncRNA-LET promotes cell apoptosis and inhibits the proliferation of post-burn skin fibroblasts. Int J Mol Med. 41:1949–1957. 2018.PubMed/NCBI

42 

Chi R, Chen X, Liu M, Zhang H, Li F, Fan X, Wang W and Lu H: Role of SNHG7-miR-653-5p-STAT2 feedback loop in regulating neuroblastoma progression. J Cell Physiol. 234:13403–13412. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Chen M, Liu P, Chen Y, Chen Z, Shen M, Liu X, Li X, Li A, Lin Y, Yang R, et al: Long noncoding RNA FAM201A mediates the radiosensitivity of esophageal squamous cell cancer by regulating ATM and mTOR expression via miR-101. Front Genet. 9:6112018. View Article : Google Scholar : PubMed/NCBI

44 

Tripathi V, Ellis JD, Shen Z, Song DY, Pan Q, Watt AT, Freier SM, Bennett CF, Sharma A, Bubulya PA, et al: The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell. 39:925–938. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Dugimont T, Curgy JJ, Wernert N, Delobelle A, Raes MB, Joubel A, Stehelin D and Coll J: The H19 gene is expressed within both epithelial and stromal components of human invasive adenocarcinomas. Biol Cell. 85:117–124. 1995. View Article : Google Scholar : PubMed/NCBI

46 

Kelley RL and Kuroda MI: Noncoding RNA genes in dosage compensation and imprinting. Cell. 103:9–12. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Koshimizu TA, Fujiwara Y, Sakai N, Shibata K and Tsuchiya H: Oxytocin stimulates expression of a noncoding RNA tumor marker in a human neuroblastoma cell line. Life Sci. 86:455–460. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Li Y, Zhuo ZJ, Zhou H, Liu J, Zhang J, Cheng J, Zhou H, Li S, Li M, He J and Xiao Y: H19 gene polymorphisms and neuroblastoma susceptibility in Chinese children: A six-center case-control study. J Cancer. 10:6358–6363. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Zhang J, Li WY, Yang Y, Yan LZ, Zhang SY, He J and Wang JX: LncRNA XIST facilitates cell growth, migration and invasion via modulating H3 histone methylation of DKK1 in neuroblastoma. Cell Cycle. 18:1882–1892. 2019. View Article : Google Scholar : PubMed/NCBI

50 

Wen Y, Gong X, Dong Y and Tang C: Long non coding RNA SNHG16 facilitates proliferation, migration, invasion and autophagy of neuroblastoma cells via sponging miR-542-3p and upregulating ATG5 expression. Onco Targets Ther. 13:263–275. 2020. View Article : Google Scholar : PubMed/NCBI

51 

Russell MR, Penikis A, Oldridge DA, Alvarez-Dominguez JR, McDaniel L, Diamond M, Padovan O, Raman P, Li Y, Wei JS, et al: CASC15-S is a tumor suppressor lncRNA at the 6p22 neuroblastoma susceptibility locus. Cancer Res. 75:3155–3166. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ye M, Xie L, Zhang J, Liu B, Liu X, He J, Ma D and Dong K: Determination of long non‑coding RNAs associated with EZH2 in neuroblastoma by RIP‑seq, RNA‑seq and ChIP‑seq. Oncol Lett 20: 1, 2020.
APA
Ye, M., Xie, L., Zhang, J., Liu, B., Liu, X., He, J. ... Dong, K. (2020). Determination of long non‑coding RNAs associated with EZH2 in neuroblastoma by RIP‑seq, RNA‑seq and ChIP‑seq. Oncology Letters, 20, 1. https://doi.org/10.3892/ol.2020.11862
MLA
Ye, M., Xie, L., Zhang, J., Liu, B., Liu, X., He, J., Ma, D., Dong, K."Determination of long non‑coding RNAs associated with EZH2 in neuroblastoma by RIP‑seq, RNA‑seq and ChIP‑seq". Oncology Letters 20.4 (2020): 1.
Chicago
Ye, M., Xie, L., Zhang, J., Liu, B., Liu, X., He, J., Ma, D., Dong, K."Determination of long non‑coding RNAs associated with EZH2 in neuroblastoma by RIP‑seq, RNA‑seq and ChIP‑seq". Oncology Letters 20, no. 4 (2020): 1. https://doi.org/10.3892/ol.2020.11862
Copy and paste a formatted citation
x
Spandidos Publications style
Ye M, Xie L, Zhang J, Liu B, Liu X, He J, Ma D and Dong K: Determination of long non‑coding RNAs associated with EZH2 in neuroblastoma by RIP‑seq, RNA‑seq and ChIP‑seq. Oncol Lett 20: 1, 2020.
APA
Ye, M., Xie, L., Zhang, J., Liu, B., Liu, X., He, J. ... Dong, K. (2020). Determination of long non‑coding RNAs associated with EZH2 in neuroblastoma by RIP‑seq, RNA‑seq and ChIP‑seq. Oncology Letters, 20, 1. https://doi.org/10.3892/ol.2020.11862
MLA
Ye, M., Xie, L., Zhang, J., Liu, B., Liu, X., He, J., Ma, D., Dong, K."Determination of long non‑coding RNAs associated with EZH2 in neuroblastoma by RIP‑seq, RNA‑seq and ChIP‑seq". Oncology Letters 20.4 (2020): 1.
Chicago
Ye, M., Xie, L., Zhang, J., Liu, B., Liu, X., He, J., Ma, D., Dong, K."Determination of long non‑coding RNAs associated with EZH2 in neuroblastoma by RIP‑seq, RNA‑seq and ChIP‑seq". Oncology Letters 20, no. 4 (2020): 1. https://doi.org/10.3892/ol.2020.11862
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