Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2020 Volume 20 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 20 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Beclin‑1 expression is associated with prognosis in a Bcl‑2‑dependent manner in non‑small cell lung cancer

  • Authors:
    • Hailei Du
    • Ling Chen
    • Fangxiu Luo
    • Xueyu Chen
    • Yong Li
    • Qijian Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China, Department of Respiratory and Critical Care Medicine, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai 201821, P.R. China, Department of Pathology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai 201821, P.R. China
  • Article Number: 9
    |
    Published online on: July 15, 2020
       https://doi.org/10.3892/ol.2020.11870
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Beclin‑1 and Bcl‑2 expression abnormalities have been confirmed in different types of cancer. As important regulators of autophagy and apoptosis, respectively, these molecules serve a complex role in tumorigenesis. However, limited information is currently available regarding the association between Beclin‑1 and Bcl‑2 in (NSCLC). In the present study, the expression levels of Beclin‑1 and Bcl‑2 were detected in lung cancer tissues, and their prognostic significance was analyzed for NSCLC. A total of 120 patients with lung cancer who underwent surgical resection were included in the present study. Beclin‑1 and Bcl‑2 expression was assessed using immunohistochemistry and their associations with the overall survival (OS) in patients with NSCLC was examined. The expression rate of Beclin‑1 was significantly lower in NSCLC tissues compared with that in adjacent tissues, whereas the expression rate of Bcl‑2 was significantly higher in lung cancer tissues compared with that in adjacent tissues. Additionally, Beclin‑1 and Bcl‑2 protein expression was strongly associated (P<0.05) in NSCLC. Patients with NSCLC with low Beclin‑1 expression were in more advanced stages, with more lymph node metastasis and more poorly differentiated tumors. Similarly, patients with NSCLC with high Bcl‑2 expression were also in a more advanced stage and had more lymph node metastasis. Cox regression analysis revealed that the association between Bcl‑2 expression and survival was not significant, while a multivariate analysis revealed that Beclin‑1 expression was significantly associated with OS. Notably, Beclin‑1 expression was significantly associated with OS only in patients with high Bcl‑2 expression. In conclusion, the present data indicated that the autophagy activity is decreased in NSCLC. Beclin‑1 expression was downregulated, while Bcl‑2 expression was upregulated in NSCLC tissues compared with that in adjacent tissues. Additionally, these two proteins were associated with the occurrence and progression of NSCLC. Beclin‑1 may be a promising prognostic marker for patients with NSCLC with high Bcl‑2 expression. The present findings provided a more accurate prognostic assessment for patients with NSCLC. Furthermore, they may be used to actively follow‑up and promptly treat patients with a poor prognosis, which may benefit a greater number of patients with NSCLC.
View Figures

Figure 1

Figure 2

View References

1 

Nasim F, Sabath BF and Eapen GA: Lung cancer. Med Clin North Am. 103:463–473. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Cao M and Chen W: Epidemiology of lung cancer in China. Thorac Cancer. 10:3–7. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Hoy H, Lynch T and Beck M: Surgical treatment of lung cancer. Crit Care Nurs Clin North Am. 31:303–313. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Mao Y, Yang D, He J and Krasna MJ: Epidemiology of lung cancer. Surg Oncol Clin N Am. 25:439–445. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Cotzomi-Ortega I, Aguilar-Alonso P, Reyes-Leyva J and Maycotte P: Autophagy and its role in protein secretion: Implications for cancer therapy. Mediators Inflamm. 2018:42315912018. View Article : Google Scholar : PubMed/NCBI

7 

Levy JMM, Towers CG and Thorburn A: Targeting autophagy in cancer. Nat Rev Cancer. 17:528–542. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Schenk RL, Strasser A and Dewson G: BCL-2: Long and winding path from discovery to therapeutic target. Biochem Biophys Res Commun. 482:459–469. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Rahman MA, Bishayee K, Habib K, Sadra A and Huh SO: 18α-Glycyrrhetinic acid lethality for neuroblastoma cells via de-regulating the Beclin-1/Bcl-2 complex and inducing apoptosis. Biochem Pharmacol. 117:97–112. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Song S, Wang B, Gu S, Li X and Sun S: Expression of Beclin 1 and Bcl-2 in pancreatic neoplasms and its effect on pancreatic ductal adenocarcinoma prognosis. Oncol Lett. 14:7849–7861. 2017.PubMed/NCBI

11 

Jiang LC, Huang SY, Zhang DS, Zhang SH, Li WG, Zheng PH and Chen ZW: Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis. Braz J Med Biol Res. 47:252–258. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Baspinar S, Bircan S, Orhan H, Kapucuoglu N and Bozkurt KK: The relation of Beclin 1 and Bcl-2 expressions in high grade prostatic intraepithelial neoplasia and prostate adenocarcinoma: A tissue microarray study. Pathol Res Pract. 210:412–418. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, Nicholson AG, Groome P, Mitchell A, Bolejack V, et al: The IASLC lung cancer staging project: Proposals for revision of the TNM stage groupings in the forthcoming (Eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 11:39–51. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Xu HD and Qin ZH: Beclin 1, Bcl-2 and autophagy. Adv Exp Med Biol. 1206:109–126. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Guadagno E, Borrelli G, Pignatiello S, Donato A, Presta I, Arcidiacono B, Malara N, Solari D, Somma T, Cappabianca P, et al: Anti-apoptotic and anti-oxidant proteins in glioblastomas: Immunohistochemical expression of Beclin and DJ-1 and its correlation with prognosis. Int J Mol Sci. 20:40662019. View Article : Google Scholar

16 

Sun H, Yu J, Wen Z, Wang M and Chen W: Decreased expression of Beclin-1 in patients with hepatocellular carcinoma. J BUON. 24:634–641. 2019.PubMed/NCBI

17 

Chen L, Liu Y, Zhang Q, Zhang M, Han X, Li Q, Xie T, Wu Q and Sui X: p53/PCDH17/Beclin-1 proteins as prognostic predictors for urinary bladder cancer. J Cancer. 10:6207–6216. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Chen Y, Wang X, Wang G, Li Z, Wang J, Huang L, Qin Z, Yuan X, Cheng Z, Zhang S, et al: Integrating multiple omics data for the discovery of potential Beclin-1 interactions in breast cancer. Mol Biosyst. 13:991–999. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Yang Z, Ghoorun RA, Fan X, Wu P, Bai Y, Li J, Chen H, Wang L and Wang J: High expression of Beclin-1 predicts favorable prognosis for patients with colorectal cancer. Clin Res Hepatol Gastroenterol. 39:98–106. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Zheng T, Li D, He Z, Feng S and Zhao S: Prognostic and clinicopathological significance of Beclin-1 in non-small-cell lung cancer: A meta-analysis. Onco Targets Ther. 11:4167–4175. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Qiu DM, Wang GL, Chen L, Xu YY, He S, Cao XL, Qin J, Zhou JM, Zhang YX and E Q: The expression of Beclin-1, an autophagic gene, in hepatocellular carcinoma associated with clinical pathological and prognostic significance. BMC Cancer. 14:3272014. View Article : Google Scholar : PubMed/NCBI

22 

Han Y, Xue XF, Shen HG, Guo XB, Wang X, Yuan B, Guo XP, Kuang YT, Zhi QM and Zhao H: Prognostic significance of Beclin-1 expression in colorectal cancer: A meta-analysis. Asian Pac J Cancer Prev. 15:4583–4587. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Qiu XG, Chen YD, Yuan J, Zhang N, Lei T, Liu J and Yang M: Functional BCL-2 rs2279115 promoter noncoding variant contributes to glioma predisposition, especially in males. DNA Cell Biol. 38:85–90. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Chi XX, Zhang T, Chu XL, Zhen JL and Zhang DJ: The regulatory effect of Genistein on granulosa cell in ovary of rat with PCOS through Bcl-2 and Bax signaling pathways. J Vet Med Sci. 80:1348–1355. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Liu X, Cai H, Huang H, Long Z, Shi Y and Wang Y: The prognostic significance of apoptosis-related biological markers in Chinese gastric cancer patients. PLoS One. 6:e296702011. View Article : Google Scholar : PubMed/NCBI

26 

Huang Q, Li S, Cheng P, Deng M, He X, Wang Z, Yang CH, Zhao XY and Huang J: High expression of anti-apoptotic protein Bcl-2 is a good prognostic factor in colorectal cancer: Result of a meta-analysis. World J Gastroenterol. 23:5018–5033. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Callagy GM, Webbe MJ, Pharoah PD and Caldas C: Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer. BMC Cancer. 8:1532008. View Article : Google Scholar : PubMed/NCBI

28 

D'Arcy MS: Cell death: A review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int. 43:582–592. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Yu Y, Li W, Ren L, Yang C, Li D, Han X, Sun Y, Lv C and Han F: Inhibition of autophagy enhanced cobalt chloride-induced apoptosis in rat alveolar type II epithelial cells. Mol Med Rep. 18:2124–2132. 2018.PubMed/NCBI

30 

Won KY, Kim GY, Kim YW, Song JY and Lim SJ: Clinicopathologic correlation of Beclin-1 and Bcl-2 expression in human breast cancer. Hum Pathol. 41:107–112. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Du H, Chen L, Luo F, Chen X, Li Y and Cheng Q: Beclin‑1 expression is associated with prognosis in a Bcl‑2‑dependent manner in non‑small cell lung cancer. Oncol Lett 20: 9, 2020.
APA
Du, H., Chen, L., Luo, F., Chen, X., Li, Y., & Cheng, Q. (2020). Beclin‑1 expression is associated with prognosis in a Bcl‑2‑dependent manner in non‑small cell lung cancer. Oncology Letters, 20, 9. https://doi.org/10.3892/ol.2020.11870
MLA
Du, H., Chen, L., Luo, F., Chen, X., Li, Y., Cheng, Q."Beclin‑1 expression is associated with prognosis in a Bcl‑2‑dependent manner in non‑small cell lung cancer". Oncology Letters 20.4 (2020): 9.
Chicago
Du, H., Chen, L., Luo, F., Chen, X., Li, Y., Cheng, Q."Beclin‑1 expression is associated with prognosis in a Bcl‑2‑dependent manner in non‑small cell lung cancer". Oncology Letters 20, no. 4 (2020): 9. https://doi.org/10.3892/ol.2020.11870
Copy and paste a formatted citation
x
Spandidos Publications style
Du H, Chen L, Luo F, Chen X, Li Y and Cheng Q: Beclin‑1 expression is associated with prognosis in a Bcl‑2‑dependent manner in non‑small cell lung cancer. Oncol Lett 20: 9, 2020.
APA
Du, H., Chen, L., Luo, F., Chen, X., Li, Y., & Cheng, Q. (2020). Beclin‑1 expression is associated with prognosis in a Bcl‑2‑dependent manner in non‑small cell lung cancer. Oncology Letters, 20, 9. https://doi.org/10.3892/ol.2020.11870
MLA
Du, H., Chen, L., Luo, F., Chen, X., Li, Y., Cheng, Q."Beclin‑1 expression is associated with prognosis in a Bcl‑2‑dependent manner in non‑small cell lung cancer". Oncology Letters 20.4 (2020): 9.
Chicago
Du, H., Chen, L., Luo, F., Chen, X., Li, Y., Cheng, Q."Beclin‑1 expression is associated with prognosis in a Bcl‑2‑dependent manner in non‑small cell lung cancer". Oncology Letters 20, no. 4 (2020): 9. https://doi.org/10.3892/ol.2020.11870
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team