Open Access

Investigation of the association between C‑X‑C motif chemokine receptor subunits and tumor infiltration levels and prognosis in patients with early‑stage pancreatic ductal adenocarcinoma

  • Authors:
    • Qiong-Yuan Wu
    • Cheng-Kun Yang
    • Liang-Jun Rong
    • Jun-Chan Li
    • Long-Ming Lei
  • View Affiliations

  • Published online on: July 16, 2020     https://doi.org/10.3892/ol.2020.11877
  • Article Number: 16
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the malignancies with the highest morality rate due to postoperative local invasion and distant metastasis. Although C‑X‑C motif chemokine receptor (CXCR) subunits have been reported as prognostic indicators in gastric cancer, the prognostic value of CXCR subunits in PDAC remains poorly understood. In the present study, the expression levels and biological functions of CXCR subunits were investigated using multiple publicly accessible bioinformatic platforms and databases. Survival analysis was used to evaluate the prognostic value of CXCR subunits in 112 early‑stage PDAC cases by setting the median expression levels as the cut‑off values. A nomogram was constructed to combine CXCR subunit expression levels and clinical data for prognosis prediction. Moreover, the association between CXCR subunit expression levels and tumor infiltration levels were detected in PDAC. The expression levels of CXCR subunits were elevated in PDAC tumor tissues. In the multivariate Cox proportional risk regression model, high CXCR2, CXCR4 and CXCR6 expression levels in early‑stage PDAC were associated with a more favorable prognosis. Further, it was demonstrated that the differential expression levels of CXCR subunits in PDAC for combined survival analysis could contribute to risk stratification. The nomogram model demonstrated the contribution of CXCR subunits and clinical features in the prognosis of PDAC. Gene Set Enrichment Analysis suggested that CXCR subunits serve a role in immunomodulatory functions. The expression levels and somatic copy number alterations of CXCR subunits were associated with tumor infiltration levels in PDAC. CXCR subunits were associated with prognosis in patients with early‑stage PDAC and may be potential drug targets for the treatment of pancreatic cancer.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wu Q, Yang C, Rong L, Li J and Lei L: Investigation of the association between C‑X‑C motif chemokine receptor subunits and tumor infiltration levels and prognosis in patients with early‑stage pancreatic ductal adenocarcinoma. Oncol Lett 20: 16, 2020
APA
Wu, Q., Yang, C., Rong, L., Li, J., & Lei, L. (2020). Investigation of the association between C‑X‑C motif chemokine receptor subunits and tumor infiltration levels and prognosis in patients with early‑stage pancreatic ductal adenocarcinoma. Oncology Letters, 20, 16. https://doi.org/10.3892/ol.2020.11877
MLA
Wu, Q., Yang, C., Rong, L., Li, J., Lei, L."Investigation of the association between C‑X‑C motif chemokine receptor subunits and tumor infiltration levels and prognosis in patients with early‑stage pancreatic ductal adenocarcinoma". Oncology Letters 20.4 (2020): 16.
Chicago
Wu, Q., Yang, C., Rong, L., Li, J., Lei, L."Investigation of the association between C‑X‑C motif chemokine receptor subunits and tumor infiltration levels and prognosis in patients with early‑stage pancreatic ductal adenocarcinoma". Oncology Letters 20, no. 4 (2020): 16. https://doi.org/10.3892/ol.2020.11877