Open Access

Prevalence of human papillomavirus infection and type distribution among Uyghur females in Xinjiang, northwest China

  • Authors:
    • Xiaolong Yan
    • Yan Huang
    • Mei Zhang
    • Xin Hu
    • Ke Li
    • Mingxia Jing
  • View Affiliations

  • Published online on: July 16, 2020     https://doi.org/10.3892/ol.2020.11886
  • Article Number: 25
  • Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Human papillomavirus (HPV) infection has a key role in the development of cervical cancer. The present study aimed to determine the HPV type distribution among females of Uyghur ethnicity in Xinjiang province, northwest China. A total of 12,165 individuals aged 30‑79 years from 12 villages in Zepu County, Kashgar Prefecture, Xinjiang province were recruited for screening. Cervical and vaginal swabs from each subject were collected by gynecologists and tested for HPV DNA using Luminex xMAP technology. The results indicated that the overall HPV prevalence was 9.34% (1,136/12,165) in the present cohort; 7.41% (901/12,165) of the individuals were positive for high-risk type HPV (HR‑HPV) and 1.64% (200/12,165) were positive for multiple types. Among the individuals who tested positive for HR‑HPV types, the three most prevalent types were HPV16 (2.83%), HPV31 (0.99%) and HPV68 (0.88%). Subgroup analysis by age indicated that the highest frequency of HPV infections occurred in subjects aged >60 years. The most common genotype combinations in subjects with multiple types were HPV16 + HPV54, HPV16 + HPV31 and HPV16 + HPV68. The present study provided data on the prevalence and type distribution of HPV infections among Uyghur females in Xinjiang province, northwestern China, which will assist in the assessment of the potential cost-effectiveness of HPV screening and vaccination in this population. The data will also facilitate the determination of HPV68 and 54 strains that should be included in the multi-type vaccine and the establishment of a vaccination program that caters for the different age groups of the Uyghur population.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yan X, Huang Y, Zhang M, Hu X, Li K and Jing M: Prevalence of human papillomavirus infection and type distribution among Uyghur females in Xinjiang, northwest China. Oncol Lett 20: 25, 2020
APA
Yan, X., Huang, Y., Zhang, M., Hu, X., Li, K., & Jing, M. (2020). Prevalence of human papillomavirus infection and type distribution among Uyghur females in Xinjiang, northwest China. Oncology Letters, 20, 25. https://doi.org/10.3892/ol.2020.11886
MLA
Yan, X., Huang, Y., Zhang, M., Hu, X., Li, K., Jing, M."Prevalence of human papillomavirus infection and type distribution among Uyghur females in Xinjiang, northwest China". Oncology Letters 20.4 (2020): 25.
Chicago
Yan, X., Huang, Y., Zhang, M., Hu, X., Li, K., Jing, M."Prevalence of human papillomavirus infection and type distribution among Uyghur females in Xinjiang, northwest China". Oncology Letters 20, no. 4 (2020): 25. https://doi.org/10.3892/ol.2020.11886