Open Access

Loss of histone H4 lysine 20 trimethylation in osteosarcoma is associated with aberrant expression ofhistone methyltransferase SUV420H2

  • Authors:
    • Lianhua Piao
    • Xiaofeng Yuan
    • Luhui Wang
    • Xiaoshuang Xu
    • Ming Zhuang
    • Jinggao Li
    • Ren Kong
    • Zhiwei Liu
  • View Affiliations

  • Published online on: July 16, 2020     https://doi.org/10.3892/ol.2020.11887
  • Article Number: 26
  • Copyright: © Piao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epigenetic modifications of histones have crucial roles in various types of cancers. The aberrant trimethylation of histone H4 at lysine 20 (H4K20) has been implicated in carcinogenesis. At present, the status of trimethylation at H4k20 (H4K20me3) in osteosarcoma (OS), the predominant bone cancer in humans, is unknown. In the present study, a genome‑wide decrease was observed in H4K20me3 levels in OS tissues and cell lines. Reduced levels of lysine methyltransferase 5C (SUV420H2), the histone methyltranferase responsible for modification of H4K20me3, was also observed in OS cells with the associated loss of H4K20me3. Furthermore, a total of 507 SUV420H2‑regulated genes were identified through RNA‑seq and a number of candidate genes were further validated. Bioinformatic analysis revealed an association between SUV420H2 and multiple signaling pathway, including the mitogen‑activated protein kinase, P53, transforming growth factor and the ErbB pathways. These results demonstrated that there are aberrant levels of H4K20me3 and SUV420H2 in OS, and highlighted H4K20me3 as a candidate biomarker for the early detection of OS.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Piao L, Yuan X, Wang L, Xu X, Zhuang M, Li J, Kong R and Liu Z: Loss of histone H4 lysine 20 trimethylation in osteosarcoma is associated with aberrant expression ofhistone methyltransferase SUV420H2. Oncol Lett 20: 26, 2020
APA
Piao, L., Yuan, X., Wang, L., Xu, X., Zhuang, M., Li, J. ... Liu, Z. (2020). Loss of histone H4 lysine 20 trimethylation in osteosarcoma is associated with aberrant expression ofhistone methyltransferase SUV420H2. Oncology Letters, 20, 26. https://doi.org/10.3892/ol.2020.11887
MLA
Piao, L., Yuan, X., Wang, L., Xu, X., Zhuang, M., Li, J., Kong, R., Liu, Z."Loss of histone H4 lysine 20 trimethylation in osteosarcoma is associated with aberrant expression ofhistone methyltransferase SUV420H2". Oncology Letters 20.4 (2020): 26.
Chicago
Piao, L., Yuan, X., Wang, L., Xu, X., Zhuang, M., Li, J., Kong, R., Liu, Z."Loss of histone H4 lysine 20 trimethylation in osteosarcoma is associated with aberrant expression ofhistone methyltransferase SUV420H2". Oncology Letters 20, no. 4 (2020): 26. https://doi.org/10.3892/ol.2020.11887