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Article Open Access

Upregulation of ECT2 is associated with transcriptional program of cancer stem cells and predicts poor clinical outcome in gastric cancer

  • Authors:
    • Dao-Yin Gong
    • Xian Chen
    • Tian‑Lin Yang
    • Yi Wang
    • Yu Guo
    • Jin‑Hao Zeng
    • Shan‑Ze Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, P.R. China, Geriatric Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, P.R. China, Department of Pathyphysiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 54
    |
    Published online on: July 27, 2020
       https://doi.org/10.3892/ol.2020.11915
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Abstract

Gastric cancer remains the third leading cause of cancer‑associated mortality worldwide. The identification of prognostic indicators that are associated with clinical characteristics is urgently required. The aim of the present study was to determine the involvement of epithelial cell transforming 2 (ECT2) in gastric cancer. The results of the present study demonstrated that ECT2 expression was upregulated in human gastric cancer samples. Furthermore, high ECT2 expression was associated with advanced Tumor‑Node‑Metastasis stage and deeper tumor invasion. ECT2 upregulation was further confirmed in several independent publicly available clinical cohorts from the Gene Expression Omnibus database. In addition, patients with gastric cancer, with high ECT2 expression exhibited a significantly shorter overall survival time than those with low ECT2 expression, and Cox regression analysis demonstrated that ECT2 expression was an independent prognostic marker for overall survival time. Characterization of the transcriptome profiles of ECT2 upregulated gastric tumors indicated that ECT2 upregulation may be associated with transcriptional features of cancer stem cells (CSCs). Additionally, BUB1 mitotic checkpoint serine/threonine kinase and E2F transcription factor 7, two genes previously reported to account for the functionality of CSCs, were strongly enriched in ECT2High gastric cancer samples. Taken together, the results of the present study suggest that ECT2 may serve as a novel marker for CSCs and may be a potential prognostic indicator in gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Gong D, Chen X, Yang TL, Wang Y, Guo Y, Zeng JH and Chen SZ: Upregulation of ECT2 is associated with transcriptional program of cancer stem cells and predicts poor clinical outcome in gastric cancer. Oncol Lett 20: 54, 2020.
APA
Gong, D., Chen, X., Yang, T., Wang, Y., Guo, Y., Zeng, J., & Chen, S. (2020). Upregulation of ECT2 is associated with transcriptional program of cancer stem cells and predicts poor clinical outcome in gastric cancer. Oncology Letters, 20, 54. https://doi.org/10.3892/ol.2020.11915
MLA
Gong, D., Chen, X., Yang, T., Wang, Y., Guo, Y., Zeng, J., Chen, S."Upregulation of ECT2 is associated with transcriptional program of cancer stem cells and predicts poor clinical outcome in gastric cancer". Oncology Letters 20.4 (2020): 54.
Chicago
Gong, D., Chen, X., Yang, T., Wang, Y., Guo, Y., Zeng, J., Chen, S."Upregulation of ECT2 is associated with transcriptional program of cancer stem cells and predicts poor clinical outcome in gastric cancer". Oncology Letters 20, no. 4 (2020): 54. https://doi.org/10.3892/ol.2020.11915
Copy and paste a formatted citation
x
Spandidos Publications style
Gong D, Chen X, Yang TL, Wang Y, Guo Y, Zeng JH and Chen SZ: Upregulation of ECT2 is associated with transcriptional program of cancer stem cells and predicts poor clinical outcome in gastric cancer. Oncol Lett 20: 54, 2020.
APA
Gong, D., Chen, X., Yang, T., Wang, Y., Guo, Y., Zeng, J., & Chen, S. (2020). Upregulation of ECT2 is associated with transcriptional program of cancer stem cells and predicts poor clinical outcome in gastric cancer. Oncology Letters, 20, 54. https://doi.org/10.3892/ol.2020.11915
MLA
Gong, D., Chen, X., Yang, T., Wang, Y., Guo, Y., Zeng, J., Chen, S."Upregulation of ECT2 is associated with transcriptional program of cancer stem cells and predicts poor clinical outcome in gastric cancer". Oncology Letters 20.4 (2020): 54.
Chicago
Gong, D., Chen, X., Yang, T., Wang, Y., Guo, Y., Zeng, J., Chen, S."Upregulation of ECT2 is associated with transcriptional program of cancer stem cells and predicts poor clinical outcome in gastric cancer". Oncology Letters 20, no. 4 (2020): 54. https://doi.org/10.3892/ol.2020.11915
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