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Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets

  • Authors:
    • Mingyuan Luan
    • Fucheng Song
    • Shuyuan Qu
    • Xi Meng
    • Junjie Ji
    • Yunbo Duan
    • Changgang Sun
    • Hongzong Si
    • Honglin Zhai
  • View Affiliations / Copyright

    Affiliations: School of Basic Medicine, Qingdao University Medical College, Qingdao, Shandong 266071, P.R. China, Department of Public Health, Qingdao University Medical College, Qingdao, Shandong 266071, P.R. China, Institute for Computational Science and Engineering, Laboratory of New Fibrous Materials and Modern Textile State Key Laboratory, Qingdao University, Qingdao, Shandong 266071, P.R. China, Department of Cancer Center, Weifang Traditional Chinese Medicine Hospital, Weifang, Shandong 262699, P.R. China, Department of Chemistry, Lanzhou University, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Luan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 58
    |
    Published online on: July 29, 2020
       https://doi.org/10.3892/ol.2020.11919
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Abstract

Lung cancer is a major cause of cancer‑associated mortality worldwide. However, the association between multi‑omics data and survival in lung cancer is not fully understood. The present study investigated the performance of the methylation survival risk model in multi‑platform integrative molecular subtypes and aimed to identify copy number (CN) variations and mutations that are associated with survival risk. The present study analyzed 439 lung adenocarcinoma cases based on DNA methylation, RNA, microRNA (miRNA), DNA copy number and mutations from The Cancer Genome Atlas datasets. First, six cancer subtypes were identified using integrating DNA methylation, RNA, miRNA and DNA copy number data. The least absolute shrinkage and selection operator (LASSO) regression algorithm was used to extract methylation sites of survival model and calculate the methylation‑based survival risk indices for all patients. Survival for patients in the high‑risk group was significantly lower compared with that for patients in the low‑risk group (P<0.05). The present study also assessed methylation‑based survival risks of the six subtypes and analyzed the association between survival risk and non‑silent mutation rate, number of segments, fraction of segments altered, aneuploidy score, number of segments with loss of heterozygosity (LOH), fraction of segments with LOH and homologous repair deficiency. Finally, the specific copy number regions and mutant genes associated with the different subtypes were identified (P<0.01). Chromosome regions 17q24.3 and 11p15.5 were identified as those with the most survival risk‑associated copy number variation regions, while a total of 29 mutant genes were significantly associated with survival (P<0.01).
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Molina JR, Yang P, Cassivi SD, Schild SE and Adjei AA: Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship. Mayo Clinic Oroceedings. 83:584–594. 2008. View Article : Google Scholar

3 

Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, Stein KD, Alteri R and Jemal A: Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 66:271–289. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Chen Z, Fillmore CM, Hammerman PS, Kim CF and Wong KK: Non-small-cell lung cancers: A heterogeneous set of diseases. Nat Rev Cancer. 14:535–546. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Del Prete C and Azzoli CG: Non-small cell lung cancer in the Era of personalized medicine: Molecular tests that matter. R I Med J (2013). 103:28–32. 2020.

6 

Muller IB, de Langen AJ, Giovannetti E and Peters GJ: Anaplastic lymphoma kinase inhibition in metastatic non-small cell lung cancer: Clinical impact of alectinib. Onco Targets Ther. 10:4535–4541. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Bergethon K, Shaw AT, Ou SH, Katayama R, Lovly CM, McDonald NT, Massion PP, Siwak-Tapp C, Gonzalez A, Fang R, et al: ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol. 30:863–870. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, et al: EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science. 304:1497–1500. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487:330–337. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Ronglai S, Olshen AB and Marc L: Integrative clustering of multiple genomic data types using a joint latent variable model with application to breast and lung cancer subtype analysis. Bioinformatics. 25:29062009. View Article : Google Scholar : PubMed/NCBI

11 

Cancer Genome Atlas Research Network. Electronic address, . simplewheeler@bcm.edu; Cancer Genome Atlas Research Network: Comprehensive and integrative genomic characterization of hepatocellular carcinoma. Cell. 169:1327–1341.e23. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Cancer Genome Atlas Research Network, . Comprehensive molecular profiling of lung adenocarcinoma. Nature. 511:543–550. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Yue QY, Zhao W, Tan Y, Deng XL and Zhang YH: PLCE1 inhibits apoptosis of non-small cell lung cancer via promoting PTEN methylation. Eur Rev Med Pharmacol Sci. 23:6211–6216. 2019.PubMed/NCBI

14 

Shahabi S, Kumaran V, Castillo J, Cong Z, Nandagopal G, Mullen DJ, Alvarado A, Correa MR, Saizan A, Goel R, et al: LINC00261 Is an epigenetically regulated tumor suppressor essential for activation of the DNA damage response. Cancer Res. 79:3050–3062. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Yun J, Mi HP, Dong JS, Nam KT, Moon DB, Ju JH, Hwang OK, Choi JS, Kim TH, Jung YS, et al: IL-32 gamma reduces lung tumor development through upregulation of TIMP-3 overexpression and hypomethylation. Cell Death Dis. 9:3062018. View Article : Google Scholar : PubMed/NCBI

16 

Kang X, Kong F, Huang K, Li L, Li Z, Wang X, Zhang W and Wu X: LncRNA MIR210HG promotes proliferation and invasion of non-small cell lung cancer by upregulating methylation of CACNA2D2 promoter via binding to DNMT1. Onco Targets Ther. 12:3779–3790. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Wang Y, Zhang Q, Gao Z, Xin S, Zhao Y, Zhang K, Shi R and Bao X: A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis. Cancer Cell Int. 19:1002019. View Article : Google Scholar : PubMed/NCBI

18 

Liu C, Li Y, Wei M, Zhao L, Yu Y and Li G: Identification of a novel glycolysis-related gene signature that can predict the survival of patients with lung adenocarcinoma. Cell Cycle. 18:568–579. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Songyang Y, Zhu W, Liu C, Li LL, Hu W, Zhou Q, Zhang H, Li W and Li D: Large-scale gene expression analysis reveals robust gene signatures for prognosis prediction in lung adenocarcinoma. PeerJ. 7:e69802019. View Article : Google Scholar : PubMed/NCBI

20 

R Core Team (2019), . R: A language and environment for statistical computing. R Foundation for Statistical Computing. (Vienna, Austria). URL https://www.R-project.org/.

21 

Colaprico A, Silva TC, Olsen C, Garofano L, Cava C, Garolini D, Sabedot TS, Malta TM, Pagnotta SM, Castiglioni I, et al: TCGAbiolinks: An R/Bioconductor package for integrative analysis of TCGA data. Nucleic Acids Res. 44:e712016. View Article : Google Scholar : PubMed/NCBI

22 

Mo Q, Wang S, Seshan VE, Olshen AB, Schultz N, Sander C, Powers RS, Ladanyi M and Shen R: Pattern discovery and cancer gene identification in integrated cancer genomic data. Proc Natl Acad Sci USA. 110:4245–4250. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Xu T, Duy LT, Liu L, Su N, Wang R, Sun B, Colaprico A, Bontempi G and Li J: CancerSubtypes: An R/Bioconductor package for molecular cancer subtype identification, validation, and visualization. Bioinformatics. 33:3131–3133. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Sadanori K and Genshiro K: Bayesian information Criteria. Information Criteria and Statistical Modeling. Springer Series in Statistics. Springer. (New York, NY). 2008.

25 

Kassambara A and Kosinski M: Survminer: Drawing Survival Curves using ‘ggplot2’. 2018.

26 

Dardis C: survMisc: Miscellaneous functions for survival data. 2018.

27 

Bolstad B: PreprocessCore: A collection of pre-processing functions. 2018.

28 

Therneau TM: A package for survival analysis in S. 2015.

29 

Simon N, Friedman J, Hastie T and Tibshirani R: Regularization paths for Cox's proportional hazards model via coordinate descent. J Stat Softw. 39:1–13. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Frank E Harrell Jr; with contributions from Charles Dupont and many others, . Hmisc: Harrell Miscellaneous. R package version 4.4-0. 2020.

31 

Caesar-Johnson SJ, Demchok JA, Felau I, et al: The immune landscape of cancer. Immunity. 81:1052018.

32 

Taylor AM, Shih J, Ha G, Gao GF, Zhang X, Berger AC, Schumacher SE, Wang C, Hu H, Liu J, et al: Genomic and functional approaches to understanding cancer aneuploidy. Cancer Cell. 33:676–689.e3. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

35 

Kassambara A: Ggpubr: ‘Ggplot2’ Based Publication Ready Plots. 2018.

36 

Mayakonda A and Koeffler HP: Maftools: Efficient analysis, visualization and summarization of MAF files from large-scale cohort based cancer studies. bioRxiv. 0526622016.doi: https://doi.org/10.1101/052662.

37 

Chun YS, Pawlik TM and Vauthey JN: 8th Edition of the AJCC cancer staging manual: Pancreas and hepatobiliary cancers. Ann Surg Oncol. 25:845–847. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Cancer Genome Atlas Research Network, . Comprehensive molecular profiling of lung adenocarcinoma. Nature. 511:543–550. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Wei JS, Matsuo K, Hsiung CA, Shiraishi K, Song M, Kim HN, Wong MP, Hong YC, Hosgood HD III, Wang Z, et al: Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. Hum Mol Genet. 26:454–465. 2016.

40 

Leng S, Wu G, Collins LB, Thomas CL, Tellez CS, Jauregui AR, Picchi MA, Zhang X, Juri DE, Desai D, et al: Implication of a chromosome 15q15.2 locus in regulating UBR1 and predisposing smokers to MGMT methylation in lung. Cancer Res. 75:3108–3117. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Tseng RC, Chang JW, Hsien FJ, Chang YH, Hsiao CF, Chen JT, Chen CY, Jou YS and Wang YC: Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer. Int J Cancer. 117:241–247. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Barter MJ, Gomez R, Hyatt S, Cheung K, Skelton AJ, Xu Y, Clark IM and Young DA: The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells. Development. 144:4510–4521. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Dai Z, Popkie AP, Zhu WG, Timmers CD, Raval A, Tannehill-Gregg S, Morrison CD, Auer H, Kratzke RA, Niehans G, et al: Bone morphogenetic protein 3B silencing in non-small-cell lung cancer. Oncogene. 23:3521–3529. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Lafont J, Talma S, Hopfgarten C and Murphy CL: Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways. J Biol Chem. 283:4778–4786. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Humbert-Claude M, Duc D, Dwir D, Thieren L, Sandström von Tobel J, Begka C, Legueux F, Velin D, Maillard MH, Do KQ, et al: Tollip, an early regulator of the acute inflammatory response in the substantia nigra. J Neuroinflammation. 13:3032016. View Article : Google Scholar : PubMed/NCBI

46 

Hsu HP, Lai MD, Lee JC, Yen MC, Weng TY, Chen WC, Fang JH and Chen YL: Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling. Sci Rep. 7:58232017. View Article : Google Scholar : PubMed/NCBI

47 

Enss ML, Cornberg M, Wagner S, Gebert A, Henrichs M, Eisenblätter R, Beil W, Kownatzki R and Hedrich HJ: Proinflammatory cytokines trigger MUC gene expression and mucin release in the intestinal cancer cell line LS180. Inflamm Res. 49:162–169. 2000. View Article : Google Scholar : PubMed/NCBI

48 

Rebouissou S, Amessou M, Couchy G, Poussin K, Imbeaud S, Pilati C, Izard T, Balabaud C, Bioulac-Sage P and Zucman-Rossi J: Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature. 457:200–204. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Lakshmanan I, Salfity S, Seshacharyulu P, Rachagani S, Thomas A, Das S, Majhi PD, Nimmakayala RK, Vengoji R, Lele SM, et al: MUC16 regulates TSPYL5 for lung cancer cell growth and chemoresistance by suppressing p53. Clin Cancer Res. 23:3906–3917. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Liu H, Liao Y, Tang M, Wu T, Tan D, Zhang S and Wang H: Trps1 is associated with the multidrug resistance of lung cancer cell by regulating MGMT gene expression. Cancer Med. 7:1921–1932. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Shen L, Yang M, Lin Q, Zhang Z, Zhu B and Miao C: COL11A1 is overexpressed in recurrent non-small cell lung cancer and promotes cell proliferation, migration, invasion and drug resistance. Oncol Rep. 36:877–885. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Qiu Z, Lin A, Li K, Lin W, Wang Q, Wei T, Zhu W, Luo P and Zhang J: A novel mutation panel for predicting etoposide resistance in small-cell lung cancer. Drug Des Devel Ther. 13:2021–2041. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Teng JF, Mei QB, Zhou XG, Tang Y, Xiong R, Qiu WQ, Pan R, Law BY, Wong VK, Yu CL, et al: Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer. Cancers. 12:1932020. View Article : Google Scholar

54 

Sun H and Wu YL: Dacomitinib in non-small-cell lung cancer: A comprehensive review for clinical application. Future Oncol. 15:2769–2777. 2019. View Article : Google Scholar : PubMed/NCBI

55 

Chen H, Chong W, Wu Q, Yao Y, Mao M and Wang X: Corrigendum: Association of LRP1B mutation with tumor mutation burden and outcomes in melanoma and non-small cell lung cancer patients treated with immune check-point blockades. Front Immunol. 10:15232019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Luan M, Song F, Qu S, Meng X, Ji J, Duan Y, Sun C, Si H and Zhai H: Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets. Oncol Lett 20: 58, 2020.
APA
Luan, M., Song, F., Qu, S., Meng, X., Ji, J., Duan, Y. ... Zhai, H. (2020). Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets. Oncology Letters, 20, 58. https://doi.org/10.3892/ol.2020.11919
MLA
Luan, M., Song, F., Qu, S., Meng, X., Ji, J., Duan, Y., Sun, C., Si, H., Zhai, H."Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets". Oncology Letters 20.4 (2020): 58.
Chicago
Luan, M., Song, F., Qu, S., Meng, X., Ji, J., Duan, Y., Sun, C., Si, H., Zhai, H."Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets". Oncology Letters 20, no. 4 (2020): 58. https://doi.org/10.3892/ol.2020.11919
Copy and paste a formatted citation
x
Spandidos Publications style
Luan M, Song F, Qu S, Meng X, Ji J, Duan Y, Sun C, Si H and Zhai H: Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets. Oncol Lett 20: 58, 2020.
APA
Luan, M., Song, F., Qu, S., Meng, X., Ji, J., Duan, Y. ... Zhai, H. (2020). Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets. Oncology Letters, 20, 58. https://doi.org/10.3892/ol.2020.11919
MLA
Luan, M., Song, F., Qu, S., Meng, X., Ji, J., Duan, Y., Sun, C., Si, H., Zhai, H."Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets". Oncology Letters 20.4 (2020): 58.
Chicago
Luan, M., Song, F., Qu, S., Meng, X., Ji, J., Duan, Y., Sun, C., Si, H., Zhai, H."Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets". Oncology Letters 20, no. 4 (2020): 58. https://doi.org/10.3892/ol.2020.11919
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