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Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression

  • Authors:
    • Zhi Yang
    • Jian-Xin Xu
    • Deng-Pan Fang
    • Jian Ke
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 62
    |
    Published online on: July 29, 2020
       https://doi.org/10.3892/ol.2020.11923
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Abstract

Prostate cancer (PCa) is one of the most common types of cancer in males globally. However, the molecular mechanisms underlying PCa progression remain largely unclear. In the present study, Gene Expression Omnibus (GEO) datasets and datasets from The Cancer Genome Atlas (TCGA) were used to analyze the expression of lysine demethylase 5B (KDM5B) in PCa. Proliferation, cell cycle and migration assays were used to detect the functional roles of KDM5B. It was found KDM5B was upregulated in PCa tissues by analyzing GEO and TCGA datasets. KDM5B knockdown significantly suppressed proliferation and cell cycle progression in PCa cells. In additional, KDM5B knockdown inhibited PCa cell migration. By analyzing a TCGA dataset, KDM5B was found to be upregulated in patients at N1 stage compared with N0 stage PCa, in patients at T3+T4 stages compared with T2 stage and in patients with Gleason score ≥8 compared with those with score ≤7. Kaplan‑Meier analysis revealed that higher expression of KDM5B was associated with shorter biochemical recurrence‑free survival and overall survival time in patients with PCa. These results suggest that expression of KDM5B may serve as a biomarker to predict the outcome of PCa.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Z, Xu J, Fang D and Ke J: Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression. Oncol Lett 20: 62, 2020.
APA
Yang, Z., Xu, J., Fang, D., & Ke, J. (2020). Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression. Oncology Letters, 20, 62. https://doi.org/10.3892/ol.2020.11923
MLA
Yang, Z., Xu, J., Fang, D., Ke, J."Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression". Oncology Letters 20.4 (2020): 62.
Chicago
Yang, Z., Xu, J., Fang, D., Ke, J."Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression". Oncology Letters 20, no. 4 (2020): 62. https://doi.org/10.3892/ol.2020.11923
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Z, Xu J, Fang D and Ke J: Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression. Oncol Lett 20: 62, 2020.
APA
Yang, Z., Xu, J., Fang, D., & Ke, J. (2020). Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression. Oncology Letters, 20, 62. https://doi.org/10.3892/ol.2020.11923
MLA
Yang, Z., Xu, J., Fang, D., Ke, J."Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression". Oncology Letters 20.4 (2020): 62.
Chicago
Yang, Z., Xu, J., Fang, D., Ke, J."Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression". Oncology Letters 20, no. 4 (2020): 62. https://doi.org/10.3892/ol.2020.11923
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